Santiago — flights from San Francisco to Santiago

Flight Deals from San Francisco to Santiago from $583

Bundle + Save
Top flight deals from leading airlines:
United AirlinesLATAM Airlines GroupAmerican AirlinesAVIANCACOPA AirlinesAir CanadaAlaska AirlinesBritish Airways+100s more
Incredible Deals

Save up to 50% on select flights with Priceline

Bundle & Save

Save an average of $240 per person when bundling your flight and hotel together with Priceline

Best Price Guarantee

If a VIP member finds a better price elsewhere, we’ll refund up to 200% of the difference

Help 24/7

We’re always here for you — reach us 24 hours a day, 7 days a week

Good to Know

Essential information to help you plan your flight from San Francisco to Santiago.

Priceline Phone Deals

Book with an agent for great rates!

Call now!1 (888) 775-6158
AVIANCAAVIANCAfound Oct 7
11/04/26
1:30 am
SFOSan Francisco International Airport
23h 15mSALMonseñor Óscar Arnulfo Romero International AirportBOGEl Dorado International Airport
11/05/26
5:45 am
SCLComodoro Arturo Merino Benítez International Airport
11/11/26
7:30 am
SCLComodoro Arturo Merino Benítez International Airport
19h 10mBOGEl Dorado International AirportSALMonseñor Óscar Arnulfo Romero International Airport
11/11/26
9:40 pm
SFOSan Francisco International Airport
$935
AVIANCAAVIANCAfound Oct 7
11/04/26
1:30 am
SFOSan Francisco International Airport
23h 15mSALMonseñor Óscar Arnulfo Romero International AirportBOGEl Dorado International Airport
11/05/26
5:45 am
SCLComodoro Arturo Merino Benítez International Airport
11/11/26
2:10 am
SCLComodoro Arturo Merino Benítez International Airport
24h 30mBOGEl Dorado International AirportSALMonseñor Óscar Arnulfo Romero International Airport
11/11/26
9:40 pm
SFOSan Francisco International Airport
$935
LATAM Airlines GroupLATAM Airlines Groupfound Oct 7
11/04/26
6:00 am
SFOSan Francisco International Airport
20h 40mATLHartsfield Jackson Atlanta International Airport
11/05/26
7:40 am
SCLComodoro Arturo Merino Benítez International Airport
11/11/26
11:55 pm
SCLComodoro Arturo Merino Benítez International Airport
15h 54mLAXLos Angeles International Airport
11/12/26
10:49 am
SFOSan Francisco International Airport
$1,003
American AirlinesAmerican Airlinesfound Oct 11
11/02/26
12:04 pm
SFOSan Francisco International Airport
15h 41mMIAMiami International Airport
11/03/26
8:45 am
SCLComodoro Arturo Merino Benítez International Airport
11/09/26
10:30 pm
SCLComodoro Arturo Merino Benítez International Airport
18h 54mMIAMiami International Airport
11/10/26
12:24 pm
SFOSan Francisco International Airport
$1,026
Flight plus hotel
BUNDLE + SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

AVIANCAAVIANCAfound Oct 7
11/04/26
1:30 am
SFOSan Francisco International Airport
32h 40mSALMonseñor Óscar Arnulfo Romero International AirportBOGEl Dorado International Airport
11/05/26
3:10 pm
SCLComodoro Arturo Merino Benítez International Airport
11/11/26
7:30 am
SCLComodoro Arturo Merino Benítez International Airport
19h 10mBOGEl Dorado International AirportSALMonseñor Óscar Arnulfo Romero International Airport
11/11/26
9:40 pm
SFOSan Francisco International Airport
$935
United AirlinesUnited Airlinesfound Oct 13
11/10/26
5:00 am
SFOSan Francisco International Airport
22h 50mIAHGeorge Bush Intercontinental Houston Airport
11/11/26
8:50 am
SCLComodoro Arturo Merino Benítez International Airport
11/17/26
10:45 pm
SCLComodoro Arturo Merino Benítez International Airport
16h 5mIAHGeorge Bush Intercontinental Houston Airport
11/18/26
9:50 am
SFOSan Francisco International Airport
$1,031
LATAM Airlines GroupLATAM Airlines Groupfound Oct 7
11/04/26
6:00 am
SFOSan Francisco International Airport
20h 40mATLHartsfield Jackson Atlanta International Airport
11/05/26
7:40 am
SCLComodoro Arturo Merino Benítez International Airport
11/11/26
11:10 pm
SCLComodoro Arturo Merino Benítez International Airport
18h 36mATLHartsfield Jackson Atlanta International Airport
11/12/26
12:46 pm
SFOSan Francisco International Airport
$1,003
COPA AirlinesCOPA Airlinesfound Oct 11
11/02/26
12:33 am
SFOSan Francisco International Airport
24h 13mPTYTocumen International Airport
11/03/26
5:46 am
SCLComodoro Arturo Merino Benítez International Airport
11/09/26
12:15 pm
SCLComodoro Arturo Merino Benítez International Airport
15h 57mPTYTocumen International Airport
11/09/26
11:12 pm
SFOSan Francisco International Airport
$1,068
American AirlinesAmerican Airlinesfound Oct 11
11/02/26
12:04 pm
SFOSan Francisco International Airport
15h 41mMIAMiami International Airport
11/03/26
8:45 am
SCLComodoro Arturo Merino Benítez International Airport
11/09/26
10:30 pm
SCLComodoro Arturo Merino Benítez International Airport
25h 47mMIAMiami International Airport
11/10/26
7:17 pm
SFOSan Francisco International Airport
$1,026
AVIANCAAVIANCAfound Oct 7
11/04/26
1:30 am
SFOSan Francisco International Airport
32h 40mSALMonseñor Óscar Arnulfo Romero International AirportBOGEl Dorado International Airport
11/05/26
3:10 pm
SCLComodoro Arturo Merino Benítez International Airport
11/11/26
2:10 am
SCLComodoro Arturo Merino Benítez International Airport
24h 30mBOGEl Dorado International AirportSALMonseñor Óscar Arnulfo Romero International Airport
11/11/26
9:40 pm
SFOSan Francisco International Airport
$935

Top Deals on flights from San Francisco to Santiago

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

7:15 am
SFOSan Francisco International Airport
20h 35m1 stop · IAH

Nov 2

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$583

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

5:00 am
SFOSan Francisco International Airport
22h 50m1 stop · IAH

Nov 2

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$583

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

12:59 am
SFOSan Francisco International Airport
27h 51m1 stop · IAH

Nov 2

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$604

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

11:59 pm
SFOSan Francisco International Airport
27h 51m1 stop · IAH

Nov 3

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$604

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

12:45 am
SFOSan Francisco International Airport
28h 5m1 stop · IAH

Nov 2

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$604

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

11:15 pm
SFOSan Francisco International Airport
28h 35m1 stop · IAH

Nov 3

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$604

San Francisco, US (SFO) - Santiago, CL (SCL)

United AirlinesUnited Airlines

Nov 1

6:35 pm
SFOSan Francisco International Airport
33h 15m1 stop · IAH

Nov 3

8:50 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$604

San Francisco, US (SFO) - Santiago, CL (SCL)

LATAM Airlines GroupLATAM Airlines Group

Nov 1

8:00 am
SFOSan Francisco International Airport
18h 40m1 stop · ATL

Nov 2

7:40 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$611

San Francisco, US (SFO) - Santiago, CL (SCL)

LATAM Airlines GroupLATAM Airlines Group

Nov 1

6:00 am
SFOSan Francisco International Airport
20h 40m1 stop · ATL

Nov 2

7:40 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$611

San Francisco, US (SFO) - Santiago, CL (SCL)

LATAM Airlines GroupLATAM Airlines Group

Nov 1

11:30 pm
SFOSan Francisco International Airport
27h 0m2 stops · ATL, BOG

Nov 3

7:30 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$626

San Francisco, US (SFO) - Santiago, CL (SCL)

LATAM Airlines GroupLATAM Airlines Group

Nov 1

11:30 pm
SFOSan Francisco International Airport
27h 0m2 stops · ATL, BOG

Nov 3

7:30 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$626

San Francisco, US (SFO) - Santiago, CL (SCL)

LATAM Airlines GroupLATAM Airlines Group

Nov 1

10:25 pm
SFOSan Francisco International Airport
28h 5m2 stops · ATL, BOG

Nov 3

7:30 am
SCLComodoro Arturo Merino Benítez International Airport
Search More

as low as

$626

Best Santiago Hotel + Flight Packages

San Francisco - Santiago packages

Best Santiago Hotel + Flight + Car Packages

San Francisco - Santiago packages

When is the best time of day to fly?

Early morning (12am - 5am) is the cheapest time of day to fly from San Francisco to Santiago. At $1,027 it is 5% cheaper than the average time. Afternoon (2pm - 5pm) is the most expensive time, 10% above average.

$1,027Early Morning$1,069Morning$1,069Midday$1,187Afternoon$1,045Evening$1,067Late Night
Show the data
When is the best time of day to fly?
Time of dayAverage fare
Early Morning$1,027
Morning$1,069
Midday$1,069
Afternoon$1,187
Evening$1,045
Late Night$1,067

What do round-trip flights from San Francisco to Santiago cost?

Share of fares in each price range.

14%$900to $1,00080%$1,000to $1,100<1%$1,100to $1,2001%$1,200to $1,300<1%$1,300to $1,4003%$1,400and up
Show the data
What do round-trip flights from San Francisco to Santiago cost?
Price rangeShare of fares
$900 to $1,00014%
$1,000 to $1,10080%
$1,100 to $1,200&lt;1%
$1,200 to $1,3001%
$1,300 to $1,400&lt;1%
$1,400 and up3%

Frequently Asked Questions

Everything you need to know about flying from San Francisco to Santiago.

What is the typical flight duration from San Francisco to Santiago?

The flight from San Francisco to Santiago covers about 5,920 miles. There is no scheduled nonstop service on this route, so the journey requires a connection.
Methodology
Flight times and distances come from our flight-schedule database, which combines published airline timetables, U.S. government schedule data from the Bureau of Transportation Statistics (BTS), and observed flight operations from the EUROCONTROL/OpenSky Open Performance Data Initiative (OPDI). The typical flight time is the median scheduled block time across all carriers on the route, computed the same way in both directions so the difference reflects prevailing winds rather than any change in method. Distance is the great-circle distance between the two airports, so the actual flown track is typically 2-5% longer.

Are there any direct flights from San Francisco to Santiago?

There are no non-stop flights from San Francisco to Santiago; every option connects. The shortest routing is via Los Angeles, a 13h 30m total trip — a Delta flight to LAX (1h 27m), an 1h 23m layover, then a LATAM Airlines non-stop to Santiago (10h 40m).
Methodology
Airlines and weekly frequencies are compiled from our flight-schedule database, which combines published airline timetables, U.S. government schedule data from the Bureau of Transportation Statistics (BTS), and observed flight operations from the EUROCONTROL/OpenSky Open Performance Data Initiative (OPDI). We count each operating carrier's scheduled weekly departures and the days it flies; where there is no nonstop service, connecting carriers are identified by linking scheduled nonstop segments through common hub airports. Where a median fare is shown for a carrier, it reflects the real fares Priceline users found on this route in the last 72 hours.

What are the ground transportation options in Santiago?

Getting from Arturo Merino Benítez International Airport (SCL) into central Santiago offers several solid options. Rideshare (Uber or Cabify) is the fastest and most-used door-to-door choice, typically taking under 30 minutes to downtown. The best balance of time and cost is the airport bus (Centropuerto or TurBus) combined with the Santiago Metro, with the bus portion running about 30 minutes to the Alameda terminal. Official blue taxis are available outside both terminals, and a trip to downtown should not exceed about CLP 15,000 (roughly $23). Car rentals are also on-site from companies like Alamo, Avis, Budget, Europcar, Econorent, Hertz, and Rosselot, with rates starting around $29 per day.
References

Are overnight (red‑eye) flights available from San Francisco to Santiago?

There are no nonstop red-eye flights from San Francisco to Santiago, but overnight connecting options exist. Copa Airlines runs an overnight leg from SFO to Panama City departing 20:21 and arriving 05:35, and Delta, LATAM, and American offer red-eyes into Santiago via Atlanta (departing 22:10, arriving 08:15), New York JFK (departing 19:50, arriving 07:25), and Miami (departing 23:00, arriving 08:10) respectively.
Methodology
Red-eye flights are identified from scheduled local departure and arrival times and block times in our flight-schedule database — built from published airline timetables and official schedule data, including U.S. Department of Transportation records for domestic routes. A flight counts as a red-eye when it departs in the afternoon or evening (3 p.m. or later local time) or in the early hours before 4 a.m., and is in the air at some point between midnight and 4 a.m. local time at both its departure airport and its arrival airport. An evening flight that lands before midnight at its destination is never counted, nor is a morning departure or a daytime long-haul that reaches the next calendar date only because of time zones. Each red-eye is labelled with its timing (for example, overnight and landing the next morning, or late-night and landing after midnight). For connecting itineraries the same rule is applied to the longer leg, from one representative day's flight search.

Which airlines usually operate this route from San Francisco to Santiago?

There is no nonstop service from San Francisco to Santiago, so travelers connect through hubs like Los Angeles, Atlanta, Miami, New York JFK, or Panama City. The quickest one-stop routing is via Los Angeles on Delta Air Lines connecting to LATAM Airlines, taking about 13 hours 30 minutes total. Common carriers on the route include LATAM Airlines for the long-haul leg, with Delta Air Lines, Alaska Airlines, American Airlines, JetBlue Airways, and Copa Airlines operating feeder segments. Copa Airlines offers a routing via Panama City on Star Alliance, while Delta and LATAM connect through SkyTeam and oneworld partners respectively.
Methodology
Airlines and weekly frequencies come from our flight-schedule database, which combines published airline timetables, U.S. government schedule data from the Bureau of Transportation Statistics (BTS), and observed flight operations from the EUROCONTROL/OpenSky Open Performance Data Initiative (OPDI). We count each operating carrier's scheduled weekly departures and the days it flies; where there is no nonstop service, connecting carriers are identified by linking scheduled nonstop segments through common hub airports. Where a typical fare is shown for a carrier, it is the median of the real fares Priceline users found on this route in the last 72 hours.

Which airport should I use in Santiago?

Santiago has one main commercial airport, Arturo Merino Benítez International Airport, which serves all international and domestic flights. It is about 15 km northwest of downtown Santiago and is the only airport you would use for this route.

How do I get to San Francisco Intl Airport from the city center?

The fastest way from downtown San Francisco to SFO is BART, with direct rapid rail service from the International Terminal that takes about 30 minutes and costs roughly $11 one-way. Ride-share services like Uber and Lyft pick up from Level 5 of the Domestic Garage, while taxis are available at the center islands outside Arrivals; both offer door-to-door convenience but cost noticeably more than transit. Shared airport shuttles serve downtown and nearby areas, and driving yourself is possible with multiple long- and short-term parking options near the terminals, though parking fees add to the cost. BART is the most popular choice for its speed and low fare, but ride-share is favored by those with luggage or tight schedules.
References

Are there hotels or sleeping facilities at Santiago airport?

There is a hotel directly connected to both terminals at Santiago’s Arturo Merino Benítez International Airport: the Holiday Inn Santiago Airport Terminal, located directly across from the Arrivals exit. Several nearby hotels offer free airport shuttles, including the Hilton Garden Inn Santiago Airport, City Express Santiago Aeropuerto, Hotel Diego de Almagro Aeropuerto, and Wyndham Santiago Aeropuerto, all roughly 2.3 to 2.4 miles away. Sleep cabins, pods, and day rooms are not available at the airport.
References

What facilities and services are available to travelers at Santiago Comodoro Arturo Merino Benítez International Airport?

Santiago Arturo Merino Benítez International Airport offers free unlimited WiFi via the 'Nuevo Pudahuel' network, though you must reconnect every 30 minutes. Mobile charging stations and power outlets are available both landside and airside, including USB plug-in stands in front of each boarding gate. ATMs are available throughout the airport, and a Santander Bank branch operates with limited weekday hours. Afex provides 24-hour currency exchange, and a 24-hour left-luggage service operates in the international terminal. A pharmacy is located on the third floor of the domestic terminal, and a medical centre is on the first floor of the international terminal. A quiet chapel is open 24 hours, with Catholic Mass held Sundays at 11:00 AM. Duty-free shopping is available in the international terminal, with several shops operating 24 hours, and there is a business centre with videoconferencing, fax, internet, and computer workstations in the international terminal.
References

Are there accessible services or children's facilities at the San Francisco and Santiago airports?

At San Francisco International Airport, wheelchair and guided assistance is available through your airline, and travelers are encouraged to notify their airline when booking; upon arrival, approach an airline representative at the ticketing counter, or in the International Terminal use specially marked phones to dial 1-800-I-FLY-SFO. SFO also offers a Quiet Airport program, a Sensory Room, and a Hidden Disabilities Sunflower Lanyard program for discreet assistance signaling. At Arturo Merino Benítez International Airport in Santiago, disabled facilities include wheelchair-accessible Braille lifts and telephones, accessible bathrooms, and lifts with speakers and emergency lights, with aid stations for passengers with reduced mobility in Pier D and Pier F. Children's play areas are available in Pier D and Pier F at the Santiago airport.
References

What aircraft are typically used on flights from San Francisco to Santiago?

There is no nonstop service from San Francisco to Santiago, so flights connect through hubs like Panama City, Los Angeles, New York, Atlanta, or Miami. Copa Airlines' one-stop option via Panama City most often uses a Boeing 737 MAX 9 on the long leg, while LATAM's connections via Los Angeles, New York, or Miami fly Boeing 787-8s, and Delta's via Atlanta uses an Airbus A350-900. A few LATAM connections through Miami also appear on Boeing 787-8s.
Methodology
Aircraft types come from our flight-schedule database, which combines published airline timetables, U.S. government schedule data from the Bureau of Transportation Statistics (BTS), and observed flight operations from the EUROCONTROL/OpenSky Open Performance Data Initiative (OPDI). For U.S. routes the type is grounded in the tail number that actually operated the flight; elsewhere it comes from the airline's filed equipment code. Where the source does not commit to a specific variant we name the aircraft family (for example Airbus A320 family) rather than guess, and where no reliable type is on file the aircraft is omitted rather than estimated. Types describe typical scheduled equipment and can vary with seasonal or day-of-week assignments and last-minute swaps.

Which airline alliances serve flights from San Francisco to Santiago?

There is no nonstop service from San Francisco to Santiago; you'll connect, and the carriers that actually operate this route span several alliances. Delta (SkyTeam) and American (oneworld) fly the long leg to Santiago via their own hubs, Copa Airlines (Star Alliance) connects through Panama City, and Alaska Airlines (oneworld) feeds shorter legs into LATAM connections. LATAM — the dominant long-haul carrier here — and JetBlue belong to no alliance at all.
Methodology
Airlines and weekly frequencies are compiled from our flight-schedule database, which combines published airline timetables, U.S. government schedule data from the Bureau of Transportation Statistics (BTS), and observed flight operations from the EUROCONTROL/OpenSky Open Performance Data Initiative (OPDI). We count each operating carrier's scheduled weekly departures and the days it flies; where there is no nonstop service, connecting carriers are identified by linking scheduled nonstop segments through common hub airports. Where a median fare is shown for a carrier, it reflects the real fares Priceline users found on this route in the last 72 hours.

What are the best airport lounge options when departing from San Francisco?

When departing from San Francisco International, passengers have a strong choice of pay-per-use and membership lounges across the terminals, including the Alaska Lounge and American Airlines Admirals Club in Terminal 1, the Air Canada Maple Leaf Lounge and Delta Sky Club in Terminal 2, and the United Clubs and Centurion Lounge in Terminal 3. The Club SFO in Terminal 1 near Gate B6 offers walk-in access for $45, showers for a $25 fee, and is also reachable via a short post-security walk from International Terminal A. In the International Terminal, the Air France-KLM Lounge, Golden Gate Lounge, and a United Club are available, while first and business class travelers can use airline lounges such as the British Airways Lounge, Cathay Pacific First and Business Class Lounge, and United Polaris Lounge. The United Polaris Lounge near Gate G1 includes shower suites and a dedicated rest zone. The Centurion Lounge in Terminal 3 is currently closed through 2027.
References

Are same‑day changes or standby possible on this route?

Same‑day changes or standby depend on the airline and fare class; flexible and premium tickets generally allow them, while Basic Economy does not.