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Flight Deals to Santiago from $385

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Stops

  • Up to 1 stop
    $759
  • Up to 2 stops
    $779

Airlines

  • Air Canada
    $1474
  • AVIANCA
    $1018
  • COPA Airlines
    $1018
  • LATAM Airlines Group
    $759

Cabin Class

  • Economy
    $759

Departure Airports

  • Detroit Metropolitan Airport
    $759

Arrival Airports

  • Comodoro Arturo Merino Benítez International Airport
    $759

Layover Airports

  • Chicago O Hare Airport
    $1018
  • El Dorado International Airport
    $1018
  • George Bush Intercontinental Houston Airport
    $1157
  • Hartsfield Jackson Atlanta International Airport
    $785
  • Jorge Chávez International Airport
    $779
  • Miami International Airport
    $759
  • Montreal Trudeau Airport
    $1531
  • New York John F Kennedy Airport
    $759
  • Newark Liberty Airport
    $1157
  • Tocumen International Airport
    $1018
  • Toronto Pearson Airport
    $1474
  • Washington Dulles Airport
    $1018

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On average save $240 per traveler
LATAM Airlines Group Logo
LATAM Airlines Group

10/23/25

DTW
17h 30m
JFK

10/24/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

11/11/25

SCL
21h 9m
MIA

11/11/25

DTW
$759
Free cancellation within 83 hours of booking
LATAM Airlines Group Logo
LATAM Airlines Group

10/22/25

DTW
16h 50m
MIA

10/23/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

11/13/25

SCL
21h 9m
MIA

11/13/25

DTW
$759
Free cancellation within 83 hours of booking
LATAM Airlines Group Logo
LATAM Airlines Group

10/22/25

DTW
22h 30m
JFK
LIM

10/23/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

11/12/25

SCL
24h 7m
JFK

11/13/25

DTW
$779
Free cancellation within 83 hours of booking
LATAM Airlines Group Logo
LATAM Airlines Group

10/23/25

DTW
17h 30m
JFK

10/24/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

11/13/25

SCL
15h 43m
LIM
ATL

11/14/25

DTW
$785
Free cancellation within 83 hours of booking
AVIANCA Logo
AVIANCA

10/22/25

DTW
18h 15m
ORD
BOG

10/23/25

SCL
AVIANCA Logo
AVIANCA

11/12/25

SCL
16h 12m
BOG
ORD

11/12/25

DTW
$1018
Free cancellation within 83 hours of booking
COPA Airlines Logo
COPA Airlines

10/22/25

DTW
28h
IAD
PTY

10/23/25

SCL
COPA Airlines Logo
COPA Airlines

11/12/25

SCL
16h 21m
PTY
IAD

11/12/25

DTW
$1018
Free cancellation within 83 hours of booking
LATAM Airlines Group Logo
LATAM Airlines Group

10/22/25

DTW
18h 53m
EWR
LIM

10/23/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

11/12/25

SCL
15h
IAH

11/13/25

DTW
$1157
Free cancellation within 83 hours of booking
Air Canada Logo
Air Canada

10/22/25

DTW
17h 45m
YYZ
BOG

10/23/25

SCL
Air Canada Logo
Air Canada

11/13/25

SCL
23h 21m
YYZ

11/14/25

DTW
$1474
Free cancellation within 83 hours of booking
Air Canada Logo
Air Canada

10/22/25

DTW
22h 10m
YYZ
BOG

10/23/25

SCL
Air Canada Logo
Air Canada

11/12/25

SCL
55h 12m
BOG
YUL

11/14/25

DTW
$1531
Free cancellation within 83 hours of booking

Top Deals on flights to Santiago

, () - Santiago, CL (SCL)

AVIANCA Logo
AVIANCA

Jul 30

DFW
31h 40m
BOG

Jul 31

SCL

as low as

$385

, () - Santiago, CL (SCL)

AVIANCA Logo
AVIANCA

May 29

DFW
23h 35m
SAL
BOG

May 30

SCL

as low as

$396

, () - Santiago, CL (SCL)

LATAM Airlines Group Logo
LATAM Airlines Group

Oct 28

DFW
24h 50m
LAX

Oct 29

SCL

as low as

$472

, () - Santiago, CL (SCL)

LATAM Airlines Group Logo
LATAM Airlines Group

Dec 2

DFW
24h
JFK

Dec 3

SCL

as low as

$472

, () - Santiago, CL (SCL)

LATAM Airlines Group Logo
LATAM Airlines Group

Oct 28

DAL
30h 34m
ATL
LIM

Oct 29

SCL

as low as

$485

, () - Santiago, CL (SCL)

LATAM Airlines Group Logo
LATAM Airlines Group

Dec 2

DAL
19h 40m
ATL
MIA

Dec 3

SCL

as low as

$485

, () - Santiago, CL (SCL)

 Logo

Nov 13

DFW
32h
MEX

Nov 14

SCL

as low as

$505

, () - Santiago, CL (SCL)

 Logo

Nov 13

DFW
12h 25m
Direct

Nov 14

SCL

as low as

$508

, () - Santiago, CL (SCL)

 Logo

Jun 26

DFW
17h 40m
ATL

Jun 27

SCL

as low as

$557

, () - Santiago, CL (SCL)

LATAM Airlines Group Logo
LATAM Airlines Group

May 30

DFW
20h 16m
ATL
GRU

May 31

SCL

as low as

$640

, () - Santiago, CL (SCL)

 Logo

Oct 27

DFW
27h 55m
MAD

Oct 28

SCL

as low as

$1373

, () - Santiago, CL (SCL)

 Logo

Dec 2

DFW
37h 10m
IST

Dec 4

SCL

as low as

$1520
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