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Business Class Flight Deals from Santiago to Buffalo from $732

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Stops

  • Up to 2 stops
    $1181

Airlines

  • American Airlines
    $1181

Cabin Class

  • First
    $1181
  • Business
    $1181

Departure Airports

  • Cibao International Airport
    $1181

Arrival Airports

  • Buffalo Niagara International Airport
    $1181

Layover Airports

  • Charlotte Douglas International Airport
    $1181
  • Chicago O Hare Airport
    $1260
  • Miami International Airport
    $1181
  • New York LaGuardia Airport
    $1217
  • Philadelphia International Airport
    $1369
  • Reagan Washington National Airport
    $1181

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On average save $240 per traveler
American Airlines Logo
American Airlines

09/13/25

STI
22h
MIA
DCA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1181
American Airlines Logo
American Airlines

09/13/25

STI
22h
MIA
DCA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1181
American Airlines Logo
American Airlines

09/13/25

STI
22h
MIA
DCA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
28h 47m
CLT
MIA

09/21/25

STI
$1206
American Airlines Logo
American Airlines

09/13/25

STI
24h 36m
MIA
DCA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1215
American Airlines Logo
American Airlines

09/13/25

STI
28h 8m
MIA
LGA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1217
American Airlines Logo
American Airlines

09/13/25

STI
28h 8m
MIA
LGA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1217
American Airlines Logo
American Airlines

09/13/25

STI
22h
MIA
DCA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
18h 54m
ORD
MIA

09/21/25

STI
$1260
American Airlines Logo
American Airlines

09/13/25

STI
24h 36m
MIA
DCA

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
18h 54m
ORD
MIA

09/21/25

STI
$1295
American Airlines Logo
American Airlines

09/13/25

STI
20h 18m
MIA
PHL

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1369
American Airlines Logo
American Airlines

09/13/25

STI
20h 18m
MIA
PHL

09/14/25

BUF
American Airlines Logo
American Airlines

09/20/25

BUF
17h 37m
CLT
MIA

09/21/25

STI
$1369

Top Deals on flights Business Class from Santiago to Buffalo

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
22h
MIA
DCA

Sep 14

BUF

as low as

$732

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
20h 18m
MIA
PHL

Sep 14

BUF

as low as

$732

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
21h 31m
MIA
CLT

Sep 14

BUF

as low as

$732

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
24h 36m
MIA
DCA

Sep 14

BUF

as low as

$766

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
23h 23m
MIA
CLT

Sep 14

BUF

as low as

$766

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
23h 34m
MIA
PHL

Sep 14

BUF

as low as

$767

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
28h 8m
MIA
LGA

Sep 14

BUF

as low as

$768

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
32h 22m
MIA
LGA

Sep 14

BUF

as low as

$844

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
21h 31m
MIA
CLT

Sep 14

BUF

as low as

$956

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 13

STI
23h 23m
MIA
CLT

Sep 14

BUF

as low as

$956

Frequently Asked Questions

Are there convenient layover flights from Santiago to Buffalo?
Yes, there are convenient 2-stop flights from Cibao International Airport to Buffalo Niagara International Airport with American Airlines. The cheapest option is priced at $1181 with layovers in Miami and Reagan Washington, taking 22 hours.
What are the most convenient layover airports for my flight?
The most convenient layover airports for your flight are Miami International Airport, Reagan Washington National Airport, and Philadelphia International Airport. These locations provide optimal connections for your trip from Santiago to Buffalo.
What is the cheapest and fastest flight from Santiago to Buffalo?
The cheapest flight is with American Airlines for $1181, 22 hours total. The fastest flight is also with American Airlines for $1369, 20 hours 18 minutes total.
What are all possible destination arrival airports?
The possible destination arrival airport for your flight is Buffalo Niagara International Airport.
What is the time difference between destination and arrival?
The time difference between Santiago and Buffalo is typically 1 hour, as Santiago is usually 1 hour ahead of Buffalo.
Is there a direct flight from Santiago to Buffalo?
There is no direct flight from Santiago to Buffalo. The cheapest available option is a 2 stops flight with American Airlines at a price of $1181.
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