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Flight Deals from Santiago to Buffalo from $245

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

  • Up to 1 stop
    $468
  • Up to 2 stops
    $504

Airlines

  • American Airlines
    $624
  • JetBlue
    $468
  • United Airlines
    $525

Cabin Class

  • Economy
    $468

Departure Airports

  • Cibao International Airport
    $468

Arrival Airports

  • Buffalo Niagara International Airport
    $468

Layover Airports

  • Charlotte Douglas International Airport
    $624
  • Chicago O Hare Airport
    $525
  • Luis Munoz Marin International Airport
    $504
  • Miami International Airport
    $624
  • New York John F Kennedy Airport
    $468
  • New York LaGuardia Airport
    $624
  • Newark Liberty Airport
    $525
  • Orlando International Airport
    $468
  • Philadelphia International Airport
    $624
  • Reagan Washington National Airport
    $624
  • Washington Dulles Airport
    $525

Best Price. GUARANTEED.

Exclusively for Priceline Members
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On average save $240 per traveler
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
8h 20m
JFK

09/17/25

STI
$468
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
12h 46m
JFK

09/18/25

STI
$468
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
8h 17m
JFK

09/17/25

STI
$468
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
11h 55m
JFK

09/17/25

STI
$468
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
6h 22m
JFK

09/18/25

STI
$468
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
10h 26m
JFK

09/18/25

STI
$468
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
15h 48m
JFK

09/18/25

STI
$495
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
10h 26m
JFK

09/18/25

STI
$504
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
12h 46m
JFK

09/18/25

STI
$504
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
6h 22m
JFK

09/18/25

STI
$504
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
8h 17m
JFK

09/17/25

STI
$504
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
11h 55m
JFK

09/17/25

STI
$504
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
8h 20m
JFK

09/17/25

STI
$504
United Airlines Logo
United Airlines

09/10/25

STI
27h 45m
EWR
IAD

09/11/25

BUF
United Airlines Logo
United Airlines

09/17/25

BUF
19h 12m
IAD
EWR

09/18/25

STI
$525
United Airlines Logo
United Airlines

09/10/25

STI
27h 45m
EWR
IAD

09/11/25

BUF
United Airlines Logo
United Airlines

09/17/25

BUF
21h 18m
ORD
EWR

09/18/25

STI
$525
United Airlines Logo
United Airlines

09/10/25

STI
27h 45m
EWR
IAD

09/11/25

BUF
United Airlines Logo
United Airlines

09/17/25

BUF
28h 32m
IAD
EWR

09/18/25

STI
$525
JetBlue Logo
JetBlue

09/10/25

STI
32h 7m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
15h 48m
JFK

09/18/25

STI
$531
JetBlue Logo
JetBlue

09/10/25

STI
10h 57m
MCO

09/10/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
24h 59m
MCO

09/18/25

STI
$532
JetBlue Logo
JetBlue

09/10/25

STI
29h 4m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
10h 26m
JFK

09/18/25

STI
$541
JetBlue Logo
JetBlue

09/10/25

STI
29h 4m
SJU
JFK

09/11/25

BUF
JetBlue Logo
JetBlue

09/17/25

BUF
11h 55m
JFK

09/17/25

STI
$541
United Airlines Logo
United Airlines

09/10/25

STI
27h 45m
EWR
IAD

09/11/25

BUF
United Airlines Logo
United Airlines

09/17/25

BUF
19h 3m
ORD
EWR

09/18/25

STI
$588
United Airlines Logo
United Airlines

09/10/25

STI
37h 1m
EWR
IAD

09/11/25

BUF
United Airlines Logo
United Airlines

09/17/25

BUF
21h 18m
ORD
EWR

09/18/25

STI
$598
American Airlines Logo
American Airlines

09/10/25

STI
21h 37m
MIA
ORD

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
17h 42m
CLT
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
20h 18m
MIA
PHL

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
17h 42m
CLT
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
20h 18m
MIA
PHL

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
18h 54m
DCA
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
21h 1m
MIA
LGA

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
17h 42m
CLT
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
21h 31m
MIA
CLT

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
17h 42m
CLT
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
10h 26m
MIA
DCA

09/10/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
18h 54m
DCA
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
21h 31m
MIA
CLT

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
18h 54m
DCA
MIA

09/18/25

STI
$624
American Airlines Logo
American Airlines

09/10/25

STI
20h 18m
MIA
PHL

09/11/25

BUF
American Airlines Logo
American Airlines

09/17/25

BUF
21h 52m
DCA
MIA

09/18/25

STI
$624

Top Deals on flights from Santiago to Buffalo

Santiago, DO (STI) - Buffalo, US (BUF)

JetBlue Logo
JetBlue

Sep 10

STI
10h 57m
MCO

Sep 10

BUF

as low as

$245

Santiago, DO (STI) - Buffalo, US (BUF)

United Airlines Logo
United Airlines

Sep 10

STI
27h 45m
EWR
IAD

Sep 11

BUF

as low as

$325

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 10

STI
10h 26m
MIA
DCA

Sep 10

BUF

as low as

$329

Santiago, DO (STI) - Buffalo, US (BUF)

JetBlue Logo
JetBlue

Sep 10

STI
29h 4m
SJU
JFK

Sep 11

BUF

as low as

$329

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 10

STI
21h 37m
MIA
ORD

Sep 11

BUF

as low as

$334

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 10

STI
20h 18m
MIA
PHL

Sep 11

BUF

as low as

$334

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 10

STI
21h 1m
MIA
LGA

Sep 11

BUF

as low as

$334

Santiago, DO (STI) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Sep 10

STI
21h 31m
MIA
CLT

Sep 11

BUF

as low as

$334

Santiago, DO (STI) - Buffalo, US (BUF)

JetBlue Logo
JetBlue

Sep 10

STI
11h 57m
MCO
JFK

Sep 10

BUF

as low as

$336

Santiago, DO (STI) - Buffalo, US (BUF)

JetBlue Logo
JetBlue

Sep 10

STI
18h 54m
SJU
JFK

Sep 11

BUF

as low as

$357

Santiago, DO (STI) - Buffalo, US (BUF)

JetBlue Logo
JetBlue

Sep 10

STI
13h 40m
JFK

Sep 11

BUF

as low as

$359

Santiago, DO (STI) - Buffalo, US (BUF)

JetBlue Logo
JetBlue

Sep 10

STI
14h 40m
JFK
BOS

Sep 10

BUF

as low as

$389

Frequently Asked Questions

What is the time difference between destination and arrival?
The time difference between Santiago and Buffalo is 1 hour, with Santiago being 1 hour ahead of Buffalo.
Is there a direct flight from Santiago to Buffalo?
There is no direct flight from Santiago to Buffalo. The cheapest option is a 1 stop flight with JetBlue at $468, and the fastest option is a 2 stops flight with American Airlines at $624.
Are there convenient layover flights from Santiago to Buffalo?
Yes, there are convenient layover flights from Santiago to Buffalo. The 1 stop flight with JetBlue costs $468 and has a layover at Orlando International Airport. Additionally, 2 stop options include JetBlue for $504, United Airlines for $525, and American Airlines for $624, with varying layovers.
What are the most convenient layover airports for the flight?
For your flight from Santiago to Buffalo, consider layovers at Orlando International Airport, Miami International Airport, Reagan Washington National Airport, Luis Munoz Marin International Airport, and Newark Liberty Airport.
What are the cheapest and fastest flights from Santiago to Buffalo?
The cheapest flight is with JetBlue for $468, taking 10 hours 57 minutes. The fastest is with American Airlines for $624, taking 10 hours 26 minutes.
What are all possible destination arrival airports?
The possible destination arrival airport is Buffalo Niagara International Airport. Layover airports include Orlando International Airport, Miami International Airport, Reagan Washington National Airport, Luis Munoz Marin International Airport, New York John F Kennedy Airport, Newark Liberty Airport, and Washington Dulles Airport.
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