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Flight Deals from Buffalo to Santiago from $201

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Stops

  • Up to 1 stop
    $494
  • Up to 2 stops
    $525

Airlines

  • American Airlines
    $564
  • JetBlue
    $494
  • United Airlines
    $581

Cabin Class

  • Economy
    $494

Departure Airports

  • Buffalo Niagara International Airport
    $494

Arrival Airports

  • Cibao International Airport
    $494

Layover Airports

  • Charlotte Douglas International Airport
    $564
  • Chicago O Hare Airport
    $581
  • General Edward Lawrence Logan International Airport
    $541
  • Luis Munoz Marin International Airport
    $525
  • Miami International Airport
    $564
  • New York John F Kennedy Airport
    $494
  • Newark Liberty Airport
    $581
  • Orlando International Airport
    $501
  • Philadelphia International Airport
    $564
  • Reagan Washington National Airport
    $564
  • Washington Dulles Airport
    $581

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE
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On average save $240 per traveler
JetBlue Logo
JetBlue

09/07/25

BUF
8h 13m
JFK

09/07/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
22h 59m
JFK

09/15/25

BUF
$494
JetBlue Logo
JetBlue

09/07/25

BUF
8h 13m
JFK

09/07/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
26h 34m
JFK

09/15/25

BUF
$494
JetBlue Logo
JetBlue

09/07/25

BUF
8h 13m
JFK

09/07/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
23h 59m
JFK

09/15/25

BUF
$494
JetBlue Logo
JetBlue

09/07/25

BUF
8h 13m
JFK

09/07/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
10h 57m
MCO

09/14/25

BUF
$501
JetBlue Logo
JetBlue

09/07/25

BUF
20h 21m
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
22h 59m
JFK

09/15/25

BUF
$514
JetBlue Logo
JetBlue

09/07/25

BUF
26h 45m
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
10h 57m
MCO

09/14/25

BUF
$522
JetBlue Logo
JetBlue

09/07/25

BUF
20h 21m
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
10h 57m
MCO

09/14/25

BUF
$522
JetBlue Logo
JetBlue

09/07/25

BUF
24h 59m
MCO

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
23h 59m
JFK

09/15/25

BUF
$524
JetBlue Logo
JetBlue

09/07/25

BUF
24h 59m
MCO

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
22h 59m
JFK

09/15/25

BUF
$524
JetBlue Logo
JetBlue

09/07/25

BUF
30h 50m
JFK
SJU

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
22h 59m
JFK

09/15/25

BUF
$525
JetBlue Logo
JetBlue

09/07/25

BUF
30h 50m
JFK
SJU

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
23h 59m
JFK

09/15/25

BUF
$525
JetBlue Logo
JetBlue

09/07/25

BUF
30h 50m
JFK
SJU

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
26h 34m
JFK

09/15/25

BUF
$525
JetBlue Logo
JetBlue

09/07/25

BUF
30h 50m
JFK
SJU

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
10h 57m
MCO

09/14/25

BUF
$532
JetBlue Logo
JetBlue

09/07/25

BUF
31h 20m
BOS
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
22h 59m
JFK

09/15/25

BUF
$541
JetBlue Logo
JetBlue

09/07/25

BUF
28h 47m
BOS
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
23h 59m
JFK

09/15/25

BUF
$541
JetBlue Logo
JetBlue

09/07/25

BUF
25h 45m
BOS
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
22h 59m
JFK

09/15/25

BUF
$541
JetBlue Logo
JetBlue

09/07/25

BUF
31h 20m
BOS
JFK

09/08/25

STI
JetBlue Logo
JetBlue

09/14/25

STI
23h 59m
JFK

09/15/25

BUF
$541
American Airlines Logo
American Airlines

09/07/25

BUF
16h 58m
CLT
MIA

09/08/25

STI
American Airlines Logo
American Airlines

09/14/25

STI
23h 34m
MIA
PHL

09/15/25

BUF
$564
American Airlines Logo
American Airlines

09/07/25

BUF
22h 45m
CLT
MIA

09/08/25

STI
American Airlines Logo
American Airlines

09/14/25

STI
22h
MIA
DCA

09/15/25

BUF
$564
American Airlines Logo
American Airlines

09/07/25

BUF
16h 58m
CLT
MIA

09/08/25

STI
American Airlines Logo
American Airlines

09/14/25

STI
22h
MIA
DCA

09/15/25

BUF
$564
American Airlines Logo
American Airlines

09/07/25

BUF
22h 45m
CLT
MIA

09/08/25

STI
American Airlines Logo
American Airlines

09/14/25

STI
23h 34m
MIA
PHL

09/15/25

BUF
$564
United Airlines Logo
United Airlines

09/07/25

BUF
9h 12m
IAD
EWR

09/07/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
17h 22m
EWR
IAD

09/15/25

BUF
$581
United Airlines Logo
United Airlines

09/07/25

BUF
18h 41m
ORD
EWR

09/08/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
21h 43m
EWR
IAD

09/15/25

BUF
$581
United Airlines Logo
United Airlines

09/07/25

BUF
19h 46m
IAD
EWR

09/08/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
21h 43m
EWR
IAD

09/15/25

BUF
$581
United Airlines Logo
United Airlines

09/07/25

BUF
9h 12m
IAD
EWR

09/07/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
21h 43m
EWR
IAD

09/15/25

BUF
$581
United Airlines Logo
United Airlines

09/07/25

BUF
19h 46m
IAD
EWR

09/08/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
17h 22m
EWR
IAD

09/15/25

BUF
$581
United Airlines Logo
United Airlines

09/07/25

BUF
18h 41m
ORD
EWR

09/08/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
17h 22m
EWR
IAD

09/15/25

BUF
$581
American Airlines Logo
American Airlines

09/07/25

BUF
30h 27m
PHL
MIA

09/08/25

STI
American Airlines Logo
American Airlines

09/14/25

STI
23h 34m
MIA
PHL

09/15/25

BUF
$583
American Airlines Logo
American Airlines

09/07/25

BUF
30h 27m
PHL
MIA

09/08/25

STI
American Airlines Logo
American Airlines

09/14/25

STI
22h
MIA
DCA

09/15/25

BUF
$583
United Airlines Logo
United Airlines

09/07/25

BUF
29h 52m
ORD
EWR

09/08/25

STI
United Airlines Logo
United Airlines

09/14/25

STI
17h 22m
EWR
IAD

09/15/25

BUF
$597

Top Deals on flights from Buffalo to Santiago

Buffalo, US (BUF) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Sep 7

BUF
8h 13m
JFK

Sep 7

STI

as low as

$201

Buffalo, US (BUF) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Sep 7

BUF
20h 21m
JFK

Sep 8

STI

as low as

$232

Buffalo, US (BUF) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Sep 7

BUF
30h 50m
JFK
SJU

Sep 8

STI

as low as

$234

Buffalo, US (BUF) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Sep 7

BUF
24h 59m
MCO

Sep 8

STI

as low as

$237

Buffalo, US (BUF) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Sep 7

BUF
19h 21m
BOS
JFK

Sep 8

STI

as low as

$238

Buffalo, US (BUF) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Sep 7

BUF
29h 50m
BOS
SJU

Sep 8

STI

as low as

$243

Buffalo, US (BUF) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Sep 7

BUF
18h 41m
ORD
EWR

Sep 8

STI

as low as

$262

Buffalo, US (BUF) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Sep 7

BUF
9h 12m
IAD
EWR

Sep 7

STI

as low as

$262

Buffalo, US (BUF) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Sep 7

BUF
19h 46m
IAD
EWR

Sep 8

STI

as low as

$262

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 7

BUF
16h 58m
CLT
MIA

Sep 8

STI

as low as

$268

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 7

BUF
22h 45m
CLT
MIA

Sep 8

STI

as low as

$274

Buffalo, US (BUF) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Sep 7

BUF
29h 52m
ORD
EWR

Sep 8

STI

as low as

$284

Frequently Asked Questions

Are there convenient layover flights from Buffalo to Santiago?
Yes, there are convenient layover flights from Buffalo to Santiago. JetBlue offers a 1 stop flight for $494 with a layover in New York. United Airlines has a 1 stop flight for $625 with a layover in Newark. Additionally, 2 stop flights are available with JetBlue, American Airlines, and United Airlines.
What are the most convenient layover airports for the flight?
For your flight from Buffalo to Santiago, convenient layover airports include New York John F Kennedy Airport with JetBlue, and Newark Liberty Airport with United Airlines.
What are the cheapest and fastest flights from Buffalo to Santiago?
The cheapest flight is with JetBlue for $494, taking 8 hours 13 minutes. The fastest flight is with United Airlines for $625, taking 6 hours 27 minutes.
What are all possible destination arrival airports?
Possible destination arrival airports include Cibao International Airport, New York John F Kennedy Airport, Newark Liberty Airport, Luis Munoz Marin International Airport, Charlotte Douglas International Airport, Miami International Airport, and Washington Dulles Airport.
What is the time difference between destination and arrival?
The flight from Buffalo to Santiago typically involves a time difference of 1 hour, with Santiago being ahead of Buffalo based on Eastern Standard Time.
Is there a direct flight from Buffalo to Santiago?
There is no direct flight from Buffalo to Santiago. The available options include 1 stop flights by JetBlue for $494 and United Airlines for $625, as well as 2 stops flights by JetBlue, American Airlines, and United Airlines.
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