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Business Class Flight Deals from Buffalo to Santiago from $408

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Stops

  • Up to 2 stops
    $838

Airlines

  • American Airlines
    $838

Cabin Class

  • First
    $838
  • Business
    $838

Departure Airports

  • Buffalo Niagara International Airport
    $838

Arrival Airports

  • Cibao International Airport
    $838

Layover Airports

  • Charlotte Douglas International Airport
    $838
  • Chicago O Hare Airport
    $838
  • Miami International Airport
    $838
  • Reagan Washington National Airport
    $838

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On average save $240 per traveler
American Airlines Logo
American Airlines

09/13/25

BUF
18h 54m
ORD
MIA

09/14/25

STI
American Airlines Logo
American Airlines

09/20/25

STI
22h
MIA
DCA

09/21/25

BUF
$838
American Airlines Logo
American Airlines

09/13/25

BUF
17h 37m
CLT
MIA

09/14/25

STI
American Airlines Logo
American Airlines

09/20/25

STI
22h
MIA
DCA

09/21/25

BUF
$838
American Airlines Logo
American Airlines

09/13/25

BUF
17h 37m
CLT
MIA

09/14/25

STI
American Airlines Logo
American Airlines

09/20/25

STI
22h
MIA
DCA

09/21/25

BUF
$838

Top Deals on flights Business Class from Buffalo to Santiago

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
18h 54m
ORD
MIA

Sep 14

STI

as low as

$408

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
17h 37m
CLT
MIA

Sep 14

STI

as low as

$408

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
17h 37m
CLT
MIA

Sep 14

STI

as low as

$414

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
28h 47m
CLT
MIA

Sep 14

STI

as low as

$439

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
28h 37m
LGA
MIA

Sep 14

STI

as low as

$445

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
28h 52m
ORD
MIA

Sep 14

STI

as low as

$446

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
23h 27m
CLT
MIA

Sep 14

STI

as low as

$639

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
23h 27m
CLT
MIA

Sep 14

STI

as low as

$644

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
24h 17m
PHL
MIA

Sep 14

STI

as low as

$649

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
24h 41m
ORD
MIA

Sep 14

STI

as low as

$811

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
20h 13m
PHL
MIA

Sep 14

STI

as low as

$3116

Buffalo, US (BUF) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Sep 13

BUF
28h 27m
PHL
MIA

Sep 14

STI

as low as

$3116

Frequently Asked Questions

Are there convenient layover flights from Buffalo to Santiago?
Yes, American Airlines offers convenient 2 stops flights from Buffalo Niagara International Airport to Cibao International Airport for $838. Layovers are at Chicago O Hare Airport and Miami International Airport, with a flight time of 18 hours 54 minutes.
What are the most convenient layover airports for the flight?
The most convenient layover airports for your flight are Chicago O'Hare, Miami International, and Charlotte Douglas. These airports facilitate smooth connections when flying from Buffalo to Santiago.
What are the details of the cheapest and fastest flight from Buffalo to Santiago?
The cheapest and fastest option is a 2 stops flight with American Airlines, priced at $838, taking 17 hours 37 minutes with layovers at Charlotte Douglas and Miami International Airports.
What are all possible destination arrival airports?
The possible destination arrival airport for your flight is Cibao International Airport.
What is the time difference between destination and arrival?
Your flight from Buffalo to Santiago involves significant layovers, resulting in a total flight time of 18 hours 54 minutes or 17 hours 37 minutes, but the exact time difference will vary depending on the arrival time.
Is there a direct flight from Buffalo to Santiago?
There is no direct flight from Buffalo to Santiago. The available flights are with 2 stops, specifically with American Airlines at a price of $838.

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