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Flight Deals from South Carolina to Detroit from $109

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Top Deals on flights from Charleston to Detroit

Charleston, US (CHS) - Detroit, US (DTT)

Spirit Airlines Logo
Spirit Airlines

Jul 27

CHS
2h 2m
Direct

Jul 27

DTW
Spirit Airlines Logo
Spirit Airlines

Aug 1

DTW
2h
Direct

Aug 1

CHS

as low as

$137

Charleston, US (CHS) - Detroit, US (DTT)

Spirit Airlines Logo
Spirit Airlines

Jul 17

CHS
2h 2m
Direct

Jul 17

DTW
Spirit Airlines Logo
Spirit Airlines

Jul 24

DTW
2h
Direct

Jul 24

CHS

as low as

$137

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 24

CHS
4h 6m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Jul 31

DTW
4h 28m
CLT

Jul 31

CHS

as low as

$288

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 26

CHS
6h 16m
CLT

Jul 27

DTW
American Airlines Logo
American Airlines

Jul 27

DTW
4h 24m
CLT

Jul 27

CHS

as low as

$288

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 16

CHS
7h 7m
DFW

Jul 16

DTW
American Airlines Logo
American Airlines

Jul 24

DTW
4h 46m
DCA

Jul 24

CHS

as low as

$308

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 17

CHS
4h 58m
PHL

Jul 17

DTW
American Airlines Logo
American Airlines

Jul 24

DTW
4h 28m
CLT

Jul 24

CHS

as low as

$308

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 17

CHS
4h 6m
CLT

Jul 18

DTW
American Airlines Logo
American Airlines

Jul 21

DTW
6h 40m
PHL
CLT

Jul 21

CHS

as low as

$333

Charleston, US (CHS) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 17

CHS
5h 33m
BOS

Jul 17

DTW
JetBlue Logo
JetBlue

Jul 21

DTW
8h 25m
BOS

Jul 21

CHS

as low as

$337

Charleston, US (CHS) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Aug 1

CHS
4h 19m
IAD

Aug 1

DTW
United Airlines Logo
United Airlines

Aug 3

DTW
4h 14m
IAD

Aug 3

CHS

as low as

$388

Charleston, US (CHS) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 25

CHS
8h 6m
ORD

Jul 25

DTW
United Airlines Logo
United Airlines

Jul 27

DTW
4h 14m
IAD

Jul 27

CHS

as low as

$388

Charleston, US (CHS) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 17

CHS
2h 5m
Direct

Jul 17

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 21

DTW
2h 4m
Direct

Jul 21

CHS

as low as

$388

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 17

CHS
6h 38m
CLT
PHL

Jul 17

DTW
American Airlines Logo
American Airlines

Jul 21

DTW
6h 40m
PHL
CLT

Jul 21

CHS

as low as

$398

Top Deals on flights from Myrtle Beach to Detroit

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Spirit Airlines Logo
Spirit Airlines

Jul 10

MYR
2h 5m
Direct

Jul 10

DTW
Spirit Airlines Logo
Spirit Airlines

Jul 13

DTW
1h 34m
Direct

Jul 13

MYR

as low as

$109

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Spirit Airlines Logo
Spirit Airlines

Jul 18

MYR
2h 4m
Direct

Jul 18

DTW
Spirit Airlines Logo
Spirit Airlines

Jul 24

DTW
1h 34m
Direct

Jul 24

MYR

as low as

$109

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Spirit Airlines Logo
Spirit Airlines

Jul 10

MYR
7h 40m
BOS

Jul 10

DTW
Spirit Airlines Logo
Spirit Airlines

Jul 13

DTW
1h 34m
Direct

Jul 13

MYR

as low as

$152

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Spirit Airlines Logo
Spirit Airlines

Jul 10

MYR
7h 40m
BOS

Jul 10

DTW
Spirit Airlines Logo
Spirit Airlines

Jul 13

DTW
7h 53m
LGA

Jul 13

MYR

as low as

$260

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 20

MYR
5h 8m
ATL

Jul 21

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 23

DTW
1h 54m
Direct

Jul 23

MYR

as low as

$317

Myrtle Beach, US (MYR) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 19

MYR
4h 19m
CLT

Jul 19

DTW
American Airlines Logo
American Airlines

Jul 24

DTW
4h 31m
CLT

Jul 25

MYR

as low as

$328

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 20

MYR
1h 56m
Direct

Jul 20

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 23

DTW
1h 54m
Direct

Jul 23

MYR

as low as

$337

Myrtle Beach, US (MYR) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 22

MYR
7h 7m
ORD

Jul 22

DTW
United Airlines Logo
United Airlines

Jul 23

DTW
6h 45m
EWR

Jul 23

MYR

as low as

$366

Myrtle Beach, US (MYR) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 20

MYR
5h 8m
ATL

Jul 21

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 23

DTW
6h 54m
ATL

Jul 23

MYR

as low as

$366

Myrtle Beach, US (MYR) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 10

MYR
4h 54m
CLT

Jul 11

DTW
American Airlines Logo
American Airlines

Jul 13

DTW
6h 52m
CLT

Jul 13

MYR

as low as

$388

Myrtle Beach, US (MYR) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 10

MYR
6h 28m
CLT

Jul 11

DTW
American Airlines Logo
American Airlines

Jul 13

DTW
7h 52m
ORD
CLT

Jul 13

MYR

as low as

$393

Myrtle Beach, US (MYR) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 10

MYR
9h 5m
CLT
ORD

Jul 10

DTW
American Airlines Logo
American Airlines

Jul 13

DTW
9h 37m
ORD
CLT

Jul 13

MYR

as low as

$398

Top Deals on flights from Holly Springs to Detroit

Holly Springs, US (GSP) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 31

GSP
9h 19m
DCA

Jul 31

DTW
American Airlines Logo
American Airlines

Aug 4

DTW
11h 22m
LGA

Aug 4

GSP

as low as

$475

Holly Springs, US (GSP) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 4

GSP
4h 9m
CLT

Aug 4

DTW
American Airlines Logo
American Airlines

Aug 11

DTW
9h 3m
ORD

Aug 11

GSP

as low as

$483

Holly Springs, US (GSP) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 31

GSP
4h 14m
IAD

Jul 31

DTW
United Airlines Logo
United Airlines

Aug 4

DTW
4h 2m
IAD

Aug 4

GSP

as low as

$488

Holly Springs, US (GSP) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Aug 4

GSP
6h 28m
ORD

Aug 4

DTW
United Airlines Logo
United Airlines

Aug 11

DTW
4h 22m
IAD

Aug 11

GSP

as low as

$488

Holly Springs, US (GSP) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 23

GSP
1h 50m
Direct

Jul 23

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 25

DTW
1h 47m
Direct

Jul 25

GSP

as low as

$596

Holly Springs, US (GSP) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 23

GSP
1h 50m
Direct

Jul 23

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 25

DTW
7h 38m
LGA

Jul 25

GSP

as low as

$606

Holly Springs, US (GSP) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 23

GSP
7h 3m
EWR

Jul 23

DTW
United Airlines Logo
United Airlines

Jul 25

DTW
7h 18m
EWR

Jul 25

GSP

as low as

$616

Holly Springs, US (GSP) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 23

GSP
5h 36m
ATL

Jul 23

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 25

DTW
7h 38m
LGA

Jul 25

GSP

as low as

$616

Holly Springs, US (GSP) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 23

GSP
4h 25m
CLT

Jul 23

DTW
American Airlines Logo
American Airlines

Jul 25

DTW
5h 13m
CLT

Jul 25

GSP

as low as

$616

Holly Springs, US (GSP) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 2

GSP
1h 55m
Direct

Jul 2

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 7

DTW
1h 38m
Direct

Jul 7

GSP

as low as

$718

Holly Springs, US (GSP) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 2

GSP
8h
ORD

Jul 2

DTW
United Airlines Logo
United Airlines

Jul 6

DTW
3h 52m
IAD

Jul 6

GSP

as low as

$724

Holly Springs, US (GSP) - Detroit, US (DTT)

Delta Air Lines Logo
Delta Air Lines

Jul 2

GSP
1h 55m
Direct

Jul 2

DTW
Delta Air Lines Logo
Delta Air Lines

Jul 7

DTW
6h 30m
ATL

Jul 7

GSP

as low as

$738

Top Deals on flights from Columbia to Detroit

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h 17m
CLT

Jul 26

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 35m
CLT

Aug 2

CAE

as low as

$343

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h 32m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 35m
CLT

Aug 2

CAE

as low as

$368

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 35m
CLT

Aug 2

CAE

as low as

$368

Columbia, US (CAE) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 25

CAE
4h 14m
IAD

Jul 25

DTW
United Airlines Logo
United Airlines

Aug 1

DTW
3h 54m
IAD

Aug 1

CAE

as low as

$393

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h 17m
CLT

Jul 26

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
6h 58m
DFW

Aug 1

CAE

as low as

$397

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
6h 58m
DFW

Aug 1

CAE

as low as

$422

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h 32m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
6h 58m
DFW

Aug 1

CAE

as low as

$422

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h 17m
CLT

Jul 26

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 29m
PHL

Aug 1

CAE

as low as

$437

Columbia, US (CAE) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 25

CAE
4h 14m
IAD

Jul 25

DTW
United Airlines Logo
United Airlines

Aug 1

DTW
14h 6m
IAD

Aug 2

CAE

as low as

$461

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h 32m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 29m
PHL

Aug 1

CAE

as low as

$462

Columbia, US (CAE) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

CAE
4h
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 29m
PHL

Aug 1

CAE

as low as

$462

Columbia, US (CAE) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 25

CAE
9h 2m
IAD

Jul 25

DTW
United Airlines Logo
United Airlines

Aug 1

DTW
3h 54m
IAD

Aug 1

CAE

as low as

$482

Top Deals on flights from Florence to Detroit

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
27h 42m
CLT
DCA

Jul 26

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
3h 59m
CLT

Aug 1

FLO

as low as

$540

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
4h 6m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
3h 59m
CLT

Aug 1

FLO

as low as

$544

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
4h 10m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
3h 59m
CLT

Aug 1

FLO

as low as

$544

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
4h 8m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
3h 59m
CLT

Aug 1

FLO

as low as

$544

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
7h 22m
CLT
PHL

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
3h 59m
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
7h 22m
CLT
PHL

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 28m
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
8h 14m
CLT
LGA

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 28m
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
8h 14m
CLT
LGA

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
3h 59m
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
7h 11m
CLT
ORD

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 47m
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
4h 10m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
6h 47m
ORD
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
8h 14m
CLT
LGA

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
4h 47m
CLT

Aug 1

FLO

as low as

$549

Florence, US (FLO) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jul 25

FLO
4h 6m
CLT

Jul 25

DTW
American Airlines Logo
American Airlines

Aug 1

DTW
8h 2m
PHL
CLT

Aug 1

FLO

as low as

$549