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Flight Deals from Charleston to Detroit from $144

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Bundle + Save

Top flight deals from leading airlines:

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

  • Up to 1 stop
    $290
  • Up to 3 stops
    $570
  • Up to 2 stops
    $320

Airlines

  • American Airlines
    $290
  • Delta Air Lines
    $332
  • JetBlue
    $1308
  • United Airlines
    $565

Cabin Class

  • Economy
    $290

Departure Airports

  • Charleston Air Force Base-International Airport
    $290

Arrival Airports

  • Detroit Metropolitan Airport
    $290
  • Detroit Metropolitan Area
    $320

Layover Airports

  • Charleston Air Force Base-International Airport
    $320
  • Charlotte Douglas International Airport
    $290
  • Chicago O Hare Airport
    $570
  • Cincinnati Northern Kentucky International Airport
    $1158
  • Detroit Metropolitan Airport
    $320
  • General Edward Lawrence Logan International Airport
    $1308
  • Hartsfield Jackson Atlanta International Airport
    $646
  • Miami International Airport
    $1024
  • New York John F Kennedy Airport
    $332
  • New York LaGuardia Airport
    $332
  • Newark Liberty Airport
    $565
  • Washington Dulles Airport
    $565

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
We'll refund the difference if you find a lower price.

American Airlines Logo
American Airlines

04/21/26

CHS
3h 53m
CLT

04/21/26

DTW
American Airlines Logo
American Airlines

04/22/26

DTW
3h 59m
CLT

04/22/26

CHS
$290
American Airlines Logo
American Airlines

05/07/26

CHS
4h 4m
CLT
DTW

05/08/26

DTT
American Airlines Logo
American Airlines

05/09/26

DTT
3h 48m
CLT
CHS

05/09/26

CHS
$320
Delta Air Lines Logo
Delta Air Lines

05/07/26

CHS
9h 6m
JFK
DTW

05/07/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/09/26

DTT
12h 24m
LGA
CHS

05/09/26

CHS
$332
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
Delta Air Lines Logo
Delta Air Lines

05/07/26

CHS
9h 6m
JFK

05/07/26

DTW
Delta Air Lines Logo
Delta Air Lines

05/09/26

DTW
12h 24m
LGA

05/09/26

CHS
$332
Delta Air Lines Logo
Delta Air Lines

05/07/26

CHS
9h 6m
JFK
DTW

05/07/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/09/26

DTT
2h 3m
CHS

05/09/26

CHS
$400
American Airlines Logo
American Airlines

05/12/26

CHS
3h 53m
CLT
DTW

05/12/26

DTT
American Airlines Logo
American Airlines

05/15/26

DTT
6h 46m
CLT
CHS

05/15/26

CHS
$406
American Airlines Logo
American Airlines

05/09/26

CHS
3h 53m
CLT
DTW

05/09/26

DTT
American Airlines Logo
American Airlines

05/13/26

DTT
3h 59m
CLT
CHS

05/13/26

CHS
$406
Delta Air Lines Logo
Delta Air Lines

05/07/26

CHS
2h 7m
DTW

05/07/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/09/26

DTT
2h 3m
CHS

05/09/26

CHS
$478
American Airlines Logo
American Airlines

05/18/26

CHS
4h 27m
CLT
DTW

05/18/26

DTT
American Airlines Logo
American Airlines

05/21/26

DTT
4h 7m
CLT
CHS

05/21/26

CHS
$481
United Airlines Logo
United Airlines

05/07/26

CHS
4h
IAD
DTW

05/07/26

DTT
United Airlines Logo
United Airlines

05/09/26

DTT
14h 40m
EWR
CHS

05/09/26

CHS
$565
United Airlines Logo
United Airlines

05/07/26

CHS
10h 25m
ORD
IAD
DTW

05/07/26

DTT
United Airlines Logo
United Airlines

05/09/26

DTT
14h 40m
EWR
CHS

05/09/26

CHS
$570
American Airlines Logo
American Airlines

04/29/26

CHS
4h 8m
CLT
DTW

04/29/26

DTT
American Airlines Logo
American Airlines

05/02/26

DTT
3h 59m
CLT
CHS

05/02/26

CHS
$578
Delta Air Lines Logo
Delta Air Lines

05/12/26

CHS
2h 7m
DTW

05/12/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/15/26

DTT
2h 3m
CHS

05/15/26

CHS
$636
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
Delta Air Lines Logo
Delta Air Lines

05/12/26

CHS
2h 7m
DTW

05/12/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/15/26

DTT
5h 24m
ATL
CHS

05/15/26

CHS
$646
Delta Air Lines Logo
Delta Air Lines

05/12/26

CHS
4h 36m
ATL
DTW

05/12/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/15/26

DTT
5h 24m
ATL
CHS

05/15/26

CHS
$656
United Airlines Logo
United Airlines

05/12/26

CHS
4h
IAD
DTW

05/12/26

DTT
United Airlines Logo
United Airlines

05/15/26

DTT
8h 24m
ORD
CHS

05/15/26

CHS
$696
United Airlines Logo
United Airlines

05/07/26

CHS
10h 25m
ORD
IAD
DTW

05/07/26

DTT
United Airlines Logo
United Airlines

05/09/26

DTT
7h 44m
ORD
IAD
CHS

05/09/26

CHS
$763
Delta Air Lines Logo
Delta Air Lines

05/18/26

CHS
2h 9m
DTW

05/18/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/21/26

DTT
2h 14m
CHS

05/21/26

CHS
$976
Delta Air Lines Logo
Delta Air Lines

05/18/26

CHS
2h 9m
DTW

05/18/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/21/26

DTT
4h 28m
ATL
CHS

05/21/26

CHS
$986
American Airlines Logo
American Airlines

05/11/26

CHS
12h 42m
MIA
DTW

05/11/26

DTT
American Airlines Logo
American Airlines

05/14/26

DTT
6h 46m
CLT
CHS

05/14/26

CHS
$1024
Delta Air Lines Logo
Delta Air Lines

05/11/26

CHS
5h 31m
LGA
DTW

05/11/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/14/26

DTT
2h 3m
CHS

05/14/26

CHS
$1026
Delta Air Lines Logo
Delta Air Lines

05/11/26

CHS
2h 9m
DTW

05/11/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/14/26

DTT
2h 3m
CHS

05/14/26

CHS
$1116
Delta Air Lines Logo
Delta Air Lines

05/07/26

CHS
6h 55m
ATL
CVG
DTW

05/07/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/09/26

DTT
12h 24m
LGA
CHS

05/09/26

CHS
$1158
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
JetBlue Logo
JetBlue

05/18/26

CHS
6h 48m
BOS
DTW

05/18/26

DTT
JetBlue Logo
JetBlue

05/21/26

DTT
7h 19m
BOS
CHS

05/21/26

CHS
$1308
Delta Air Lines Logo
Delta Air Lines

05/11/26

CHS
5h 31m
LGA
DTW

05/11/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/14/26

DTT
7h 17m
LGA
CHS

05/14/26

CHS
$1376
United Airlines Logo
United Airlines

05/18/26

CHS
4h 24m
IAD
DTW

05/18/26

DTT
United Airlines Logo
United Airlines

05/21/26

DTT
7h 1m
ORD
CHS

05/21/26

CHS
$1551
Delta Air Lines Logo
Delta Air Lines

05/07/26

CHS
6h 55m
ATL
CVG
DTW

05/07/26

DTT
Delta Air Lines Logo
Delta Air Lines

05/09/26

DTT
7h 21m
CVG
ATL
CHS

05/09/26

CHS
$1761

Top Deals on flights from Charleston to Detroit

Charleston, US (CHS) - Detroit, US (DTT)

 Logo

Jun 22

CHS
4h 56m
EWR

Jun 22

DTW

as low as

$144

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

May 15

CHS
4h 4m
CLT

May 16

DTW

as low as

$145

Charleston, US (CHS) - Detroit, US (DTT)

United Airlines Logo
United Airlines

May 13

CHS
8h 48m
EWR

May 13

DTW

as low as

$226

Charleston, US (CHS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Jun 28

CHS
4h 6m
CLT

Jun 28

DTW

as low as

$278

Charleston, US (CHS) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jun 22

CHS
6h 52m
IAH

Jun 22

DTW

as low as

$1317

Good to Know

Essential information to help you plan your flight from Charleston to Detroit

Cheapest Flight

$144

The lowest price we found in the last two weeks, departing Jun 22 and returning Jun 22

Airline NK1 stop ‧ 4h 56m ‧ economy

Fastest Flights

$478

The fastest flight that we found in the last two weeks, departing May 7 and returning May 9

Airline DL1 stop ‧ 2h 7m ‧ economy

Cheapest Flight Round-trip

$290

Cheapest price found in the last 14 days, departing Apr 21 and returning Apr 22

Airline AA1 stop ‧ 3h 53m ‧ economy

Cheapest Flight One-way

$144

Cheapest price found in the last 14 days, departing Jun 22

Airline NK1 stop ‧ 4h 56m ‧ economy

Cheapest Layover airport

$144

The cheapest layover airport to Detroit is currently $144

Airline NK1 stop ‧ 4h 56m ‧ economy

Best Arrival airport

$144

The best arrival airport to Detroit is currently $144

Airline NK1 stop ‧ 4h 56m ‧ economy

Best Departure airport

$144

The best departure airport to Detroit is currently $144

Airline NK1 stop ‧ 4h 56m ‧ economy

Cheapest Airline

$144

The cheapest airline to Detroit is currently $144

Airline NK1 stop ‧ 4h 56m ‧ economy

Flights to Detroit