$184 Flight Deals from Knoxville to San Francisco

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Stops

Up to 1 stop
$430

Airlines

Alaska Airlines
$778
American Airlines
$473
Frontier Airlines
$430
United Airlines
$617

Cabin Class

Economy
$430

Departure Airports

McGhee Tyson Airport
$430

Arrival Airports

Norman Y. Mineta San Jose International Airport
$433
San Francisco International Airport
$430

Layover Airports

Charlotte Douglas International Airport
$473
Chicago O Hare Airport
$617
Dallas Fort Worth International Airport
$473
Denver International Airport
$430
George Bush Intercontinental Houston Airport
$617
Washington Dulles Airport
$740

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On average save $240 per traveler

Frontier Airlines

09/07/25

5:08pm

TYS

10h 8m

DEN

09/08/25

12:16am

SFO

Frontier Airlines

09/14/25

7:07pm

SFO

21h 38m

DEN

09/15/25

7:45pm

TYS

^$430

Frontier Airlines

09/07/25

5:08pm

TYS

10h 8m

DEN

09/08/25

12:16am

SFO

Frontier Airlines

09/14/25

6:29am

SFO

6h 49m

DEN

09/14/25

4:18pm

TYS

^$430

Frontier Airlines

09/07/25

5:08pm

TYS

10h 8m

DEN

09/08/25

12:16am

SFO

Frontier Airlines

09/14/25

12:26pm

SJC

28h 19m

DEN

09/15/25

7:45pm

TYS

^$433

American Airlines

09/07/25

5:30am

TYS

7h 54m

DFW

09/07/25

10:24am

SFO

American Airlines

09/14/25

10:50pm

SFO

8h 6m

CLT

09/15/25

9:56am

TYS

^$473

American Airlines

09/07/25

5:30am

TYS

7h 54m

DFW

09/07/25

10:24am

SFO

American Airlines

09/14/25

6:00am

SFO

8h 36m

CLT

09/14/25

5:36pm

TYS

^$473

American Airlines

09/07/25

5:30am

TYS

7h 54m

DFW

09/07/25

10:24am

SFO

American Airlines

09/14/25

8:58am

SFO

7h 48m

CLT

09/14/25

7:46pm

TYS

^$473

American Airlines

09/07/25

5:30am

TYS

7h 54m

DFW

09/07/25

10:24am

SFO

American Airlines

09/14/25

7:05am

SFO

9h 41m

CLT

09/14/25

7:46pm

TYS

^$473

American Airlines

09/07/25

5:30am

TYS

7h 54m

DFW

09/07/25

10:24am

SFO

American Airlines

09/14/25

7:05am

SFO

7h 31m

CLT

09/14/25

5:36pm

TYS

^$473

American Airlines

09/07/25

6:30am

TYS

8h 46m

CLT

09/07/25

12:16pm

SFO

American Airlines

09/14/25

6:00am

SFO

8h 36m

CLT

09/14/25

5:36pm

TYS

^$541

American Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

American Airlines

09/14/25

6:00am

SFO

8h 36m

CLT

09/14/25

5:36pm

TYS

^$567

American Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

American Airlines

09/14/25

8:58am

SFO

7h 48m

CLT

09/14/25

7:46pm

TYS

^$567

American Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

American Airlines

09/14/25

7:05am

SFO

9h 41m

CLT

09/14/25

7:46pm

TYS

^$567

American Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

American Airlines

09/14/25

10:50pm

SFO

8h 6m

CLT

09/15/25

9:56am

TYS

^$567

American Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

American Airlines

09/14/25

7:05am

SFO

7h 31m

CLT

09/14/25

5:36pm

TYS

^$567

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

11:10pm

SFO

8h 3m

ORD

09/15/25

10:13am

TYS

^$617

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

11:59pm

SFO

7h 14m

ORD

09/15/25

10:13am

TYS

^$617

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

6:30am

SJC

24h 43m

ORD

09/15/25

10:13am

TYS

^$680

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

12:43am

SFO

9h 55m

IAH

09/14/25

1:38pm

TYS

^$682

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

6:28pm

SFO

12h 45m

ORD

09/15/25

10:13am

TYS

^$685

United Airlines

09/07/25

7:20am

TYS

7h 45m

IAH

09/07/25

12:05pm

SJC

United Airlines

09/14/25

11:59pm

SFO

7h 14m

ORD

09/15/25

10:13am

TYS

^$698

United Airlines

09/07/25

7:20am

TYS

7h 45m

IAH

09/07/25

12:05pm

SJC

United Airlines

09/14/25

11:10pm

SFO

8h 3m

ORD

09/15/25

10:13am

TYS

^$698

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

10:45pm

SFO

19h 11m

IAD

09/15/25

8:56pm

TYS

^$740

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

9:10pm

SFO

14h 30m

IAD

09/15/25

2:40pm

TYS

^$740

United Airlines

09/07/25

7:20am

TYS

7h 18m

IAH

09/07/25

11:38am

SFO

United Airlines

09/14/25

10:45pm

SFO

12h 55m

IAD

09/15/25

2:40pm

TYS

^$740

Alaska Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

Alaska Airlines

09/14/25

1:49pm

SJC

7h 2m

DFW

09/14/25

11:51pm

TYS

^$778

Alaska Airlines

09/07/25

4:37pm

TYS

7h 28m

DFW

09/07/25

9:05pm

SJC

Alaska Airlines

09/14/25

1:49pm

SJC

7h 2m

DFW

09/14/25

11:51pm

TYS

^$778

Alaska Airlines

09/07/25

2:07pm

TYS

9h 58m

DFW

09/07/25

9:05pm

SJC

Alaska Airlines

09/14/25

6:00am

SJC

8h 56m

DFW

09/14/25

5:56pm

TYS

^$778

Alaska Airlines

09/07/25

5:30am

TYS

10h 6m

DFW

09/07/25

12:36pm

SJC

Alaska Airlines

09/14/25

6:00am

SJC

8h 56m

DFW

09/14/25

5:56pm

TYS

^$778

Alaska Airlines

09/07/25

4:37pm

TYS

7h 28m

DFW

09/07/25

9:05pm

SJC

Alaska Airlines

09/14/25

6:00am

SJC

8h 56m

DFW

09/14/25

5:56pm

TYS

^$778

Alaska Airlines

09/07/25

2:07pm

TYS

9h 58m

DFW

09/07/25

9:05pm

SJC

Alaska Airlines

09/14/25

1:49pm

SJC

7h 2m

DFW

09/14/25

11:51pm

TYS

^$778

Top Deals on flights from Knoxville to San Francisco

Knoxville, US (TYS) - San Francisco, US (SFO)

American Airlines

Aug 22

2:23pm

TYS

4h 44m

DFW

Aug 22

7:07pm

SFO

as low as

^$184

Knoxville, US (TYS) - San Francisco, US (SFO)

United Airlines

Jan 6

4:25pm

TYS

6h 20m

DEN

Jan 6

10:45pm

SFO

as low as

^$204

Knoxville, US (TYS) - San Francisco, US (SFO)

United Airlines

Aug 22

4:40pm

TYS

6h 30m

DEN

Aug 22

11:10pm

SFO

as low as

^$234

Knoxville, US (TYS) - San Francisco, US (SFO)

United Airlines

Nov 29

5:45am

TYS

5h 29m

IAD

Nov 29

11:14am

SFO

as low as

^$307

Knoxville, US (TYS) - San Francisco, US (SFO)

United Airlines

Nov 15

8:26am

TYS

7h 9m

ORD

Nov 15

3:35pm

SFO

as low as

^$307

Knoxville, US (TYS) - San Francisco, US (SFO)

Sep 11

6:08pm

TYS

4h 33m

ATL

Sep 11

10:41pm

SFO

as low as

^$309

Knoxville, US (TYS) - San Francisco, US (SFO)

Oct 29

6:40am

TYS

6h 50m

MSP

Oct 29

1:30pm

SFO

as low as

^$309

Knoxville, US (TYS) - San Francisco, US (SFO)

Sep 3

1:00pm

TYS

5h 5m

DTW

Sep 3

6:05pm

SFO

as low as

^$309

Knoxville, US (TYS) - San Francisco, US (SFO)

Oct 31

5:44am

TYS

4h 32m

ATL

Oct 31

10:16am

SFO

as low as

^$309

Knoxville, US (TYS) - San Francisco, US (SFO)

Oct 28

12:47pm

TYS

5h 4m

DTW

Oct 28

5:51pm

SFO

as low as

^$309

Knoxville, US (TYS) - San Francisco, US (SFO)

Nov 20

6:45am

TYS

6h 34m

MSP

Nov 20

1:19pm

SFO

as low as

^$309

Knoxville, US (TYS) - San Francisco, US (SFO)

United Airlines

Aug 24

7:25pm

TYS

5h 34m

IAD

Aug 25

12:59am

SFO

as low as

^$361

Frequently Asked Questions

What is the time difference between destination and arrival?

The time difference between Knoxville and San Francisco is typically 2 hours, with San Francisco being 2 hours behind Knoxville.

Is there a direct flight from Knoxville to San Francisco?

There is no direct flight from Knoxville to San Francisco. The cheapest available flight is with Frontier Airlines for $430, and the fastest is with United Airlines for $617, both requiring a stop.

Are there convenient layover flights from Knoxville to San Francisco?

Yes, convenient one stop flights are available from Knoxville to San Francisco with Frontier Airlines at $430, American Airlines at $473, and United Airlines at $617. Additionally, a flight with Alaska Airlines to San Jose is available at $778.

What are the most convenient layover airports for my flight?

The most convenient layover airports are Denver International Airport, Dallas Fort Worth International Airport, and George Bush Intercontinental Houston Airport. Alaska Airlines also offers a layover at Dallas Fort Worth for flights to San Jose.

What is the cheapest and fastest flight from Knoxville to San Francisco?

The cheapest flight is with Frontier Airlines at $430, taking 10 hours 8 minutes. The fastest flight, different from the cheapest, is with United Airlines at $617, taking 7 hours 18 minutes.

What are all possible destination arrival airports?

Possible arrival airports include San Francisco International Airport and Norman Y. Mineta San Jose International Airport.

Flights to San Francisco

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Origins

Return flights

Cabin Class

Flight Deals from Knoxville to San Francisco from $184

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Knoxville to San Francisco

Frequently Asked Questions

Flights to San Francisco