$154 Flight Deals from San Francisco to Knoxville

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Stops

Up to 1 stop
$399

Airlines

Alaska Airlines
$408
American Airlines
$399
United Airlines
$399

Cabin Class

Economy
$399

Departure Airports

Norman Y. Mineta San Jose International Airport
$399
San Francisco International Airport
$399

Arrival Airports

McGhee Tyson Airport
$399

Layover Airports

Chicago O Hare Airport
$399
Dallas Fort Worth International Airport
$399
Denver International Airport
$399
George Bush Intercontinental Houston Airport
$399
Washington Dulles Airport
$399

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

EXPRESS DEAL

BUDGET FRIENDLY

You’re guaranteed to get one of these airlines:

Delta

Alaska

United

American

SFO TYS

Sep 20 ‧ Economy

^$141

One Way

BUDGET FRIENDLY

You’re guaranteed to get one of these airlines:

Delta

Alaska

United

American

SFO TYS

Aug 20 ‧ Economy

^$167

One Way

BUDGET FRIENDLY

You’re guaranteed to get one of these airlines:

Delta

Alaska

United

American

SFO TYS

Aug 18 ‧ Economy

^$180

One Way

United Airlines

09/13/25

5:00am

SFO

10h 10m

IAH

09/13/25

6:10pm

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 38m

DEN

09/20/25

9:18pm

SJC

^$399

American Airlines

09/13/25

2:14pm

SFO

7h 7m

DFW

09/14/25

12:21am

TYS

American Airlines

09/20/25

4:37pm

TYS

7h 31m

DFW

09/20/25

9:08pm

SJC

^$399

American Airlines

09/13/25

6:00am

SJC

6h 41m

DFW

09/13/25

3:41pm

TYS

American Airlines

09/20/25

4:37pm

TYS

7h 28m

DFW

09/20/25

9:05pm

SFO

^$399

United Airlines

09/13/25

5:00am

SFO

6h 50m

DEN

09/13/25

2:50pm

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 38m

DEN

09/20/25

9:18pm

SJC

^$399

United Airlines

09/13/25

11:10pm

SFO

8h 3m

ORD

09/14/25

10:13am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 38m

DEN

09/20/25

9:18pm

SJC

^$399

American Airlines

09/13/25

2:08pm

SJC

7h 13m

DFW

09/14/25

12:21am

TYS

American Airlines

09/20/25

6:00am

TYS

7h 27m

DFW

09/20/25

10:27am

SFO

^$399

United Airlines

09/13/25

9:10pm

SFO

10h 18m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 38m

DEN

09/20/25

9:18pm

SJC

^$399

American Airlines

09/13/25

6:00am

SJC

6h 41m

DFW

09/13/25

3:41pm

TYS

American Airlines

09/20/25

2:07pm

TYS

7h 28m

DFW

09/20/25

6:35pm

SFO

^$399

American Airlines

09/13/25

2:08pm

SJC

7h 13m

DFW

09/14/25

12:21am

TYS

American Airlines

09/20/25

2:07pm

TYS

7h 28m

DFW

09/20/25

6:35pm

SFO

^$399

American Airlines

09/13/25

5:45am

SFO

6h 56m

DFW

09/13/25

3:41pm

TYS

American Airlines

09/20/25

4:37pm

TYS

7h 31m

DFW

09/20/25

9:08pm

SJC

^$399

United Airlines

09/13/25

10:45pm

SFO

8h 43m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 38m

DEN

09/20/25

9:18pm

SJC

^$399

United Airlines

09/13/25

11:59pm

SFO

7h 14m

ORD

09/14/25

10:13am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 38m

DEN

09/20/25

9:18pm

SJC

^$399

American Airlines

09/13/25

2:08pm

SJC

7h 13m

DFW

09/14/25

12:21am

TYS

American Airlines

09/20/25

4:37pm

TYS

9h 48m

DFW

09/20/25

11:25pm

SFO

^$399

United Airlines

09/13/25

11:59pm

SFO

7h 14m

ORD

09/14/25

10:13am

TYS

United Airlines

09/20/25

10:54am

TYS

9h 14m

ORD

09/20/25

5:08pm

SFO

^$408

United Airlines

09/13/25

11:59pm

SFO

7h 14m

ORD

09/14/25

10:13am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 23m

DEN

09/20/25

9:03pm

SFO

^$408

United Airlines

09/13/25

10:45pm

SFO

8h 43m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 23m

DEN

09/20/25

9:03pm

SFO

^$408

United Airlines

09/13/25

9:10pm

SFO

10h 18m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

10:54am

TYS

9h 14m

ORD

09/20/25

5:08pm

SFO

^$408

Alaska Airlines

09/13/25

2:08pm

SJC

7h 13m

DFW

09/14/25

12:21am

TYS

Alaska Airlines

09/20/25

6:00am

TYS

9h 39m

DFW

09/20/25

12:39pm

SJC

^$408

United Airlines

09/13/25

5:00am

SFO

10h 10m

IAH

09/13/25

6:10pm

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 23m

DEN

09/20/25

9:03pm

SFO

^$408

Alaska Airlines

09/13/25

2:08pm

SJC

7h 13m

DFW

09/14/25

12:21am

TYS

Alaska Airlines

09/20/25

4:37pm

TYS

7h 31m

DFW

09/20/25

9:08pm

SJC

^$408

United Airlines

09/13/25

9:10pm

SFO

10h 18m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 23m

DEN

09/20/25

9:03pm

SFO

^$408

United Airlines

09/13/25

5:00am

SFO

6h 50m

DEN

09/13/25

2:50pm

TYS

United Airlines

09/20/25

10:54am

TYS

9h 14m

ORD

09/20/25

5:08pm

SFO

^$408

United Airlines

09/13/25

11:10pm

SFO

8h 3m

ORD

09/14/25

10:13am

TYS

United Airlines

09/20/25

4:40pm

TYS

7h 23m

DEN

09/20/25

9:03pm

SFO

^$408

United Airlines

09/13/25

10:45pm

SFO

8h 43m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

10:54am

TYS

9h 14m

ORD

09/20/25

5:08pm

SFO

^$408

United Airlines

09/13/25

5:00am

SFO

10h 10m

IAH

09/13/25

6:10pm

TYS

United Airlines

09/20/25

10:54am

TYS

9h 14m

ORD

09/20/25

5:08pm

SFO

^$408

Alaska Airlines

09/13/25

6:00am

SJC

8h 54m

DFW

09/13/25

5:54pm

TYS

Alaska Airlines

09/20/25

4:37pm

TYS

7h 31m

DFW

09/20/25

9:08pm

SJC

^$438

United Airlines

09/13/25

10:45pm

SFO

8h 43m

IAD

09/14/25

10:28am

TYS

United Airlines

09/20/25

8:52am

TYS

7h 30m

DEN

09/20/25

1:22pm

SFO

^$438

United Airlines

09/13/25

5:00am

SFO

10h 10m

IAH

09/13/25

6:10pm

TYS

United Airlines

09/20/25

8:52am

TYS

7h 30m

DEN

09/20/25

1:22pm

SFO

^$438

Alaska Airlines

09/13/25

2:08pm

SJC

7h 13m

DFW

09/14/25

12:21am

TYS

Alaska Airlines

09/20/25

2:07pm

TYS

10h 1m

DFW

09/20/25

9:08pm

SJC

^$438

Alaska Airlines

09/13/25

6:00am

SJC

8h 54m

DFW

09/13/25

5:54pm

TYS

Alaska Airlines

09/20/25

6:00am

TYS

9h 39m

DFW

09/20/25

12:39pm

SJC

^$438

Top Deals on flights from San Francisco to Knoxville

San Francisco, US (SFO) - Knoxville, US (TYS)

Sep 26

11:57pm

SFO

10h 28m

ATL

Sep 27

10:25am

TYS

as low as

^$154

San Francisco, US (SFO) - Knoxville, US (TYS)

United Airlines

Sep 26

11:00pm

SFO

11h 10m

ORD

Sep 27

10:10am

TYS

as low as

^$204

San Francisco, US (SFO) - Knoxville, US (TYS)

Sep 18

6:29am

SFO

13h 21m

DEN

Sep 18

7:50pm

TYS

as low as

^$226

San Francisco, US (SFO) - Knoxville, US (TYS)

United Airlines

Sep 3

10:45pm

SFO

11h 43m

IAD

Sep 4

10:28am

TYS

as low as

^$234

San Francisco, US (SFO) - Knoxville, US (TYS)

United Airlines

Aug 20

10:55am

SFO

12h 49m

IAH

Aug 20

11:44pm

TYS

as low as

^$272

San Francisco, US (SFO) - Knoxville, US (TYS)

American Airlines

Sep 26

11:25pm

SFO

16h 54m

ORD

Sep 27

4:19pm

TYS

as low as

^$272

San Francisco, US (SFO) - Knoxville, US (TYS)

Sep 25

11:00pm

SFO

12h 41m

DTW

Sep 26

11:41am

TYS

as low as

^$309

San Francisco, US (SFO) - Knoxville, US (TYS)

Nov 1

11:25am

SFO

9h 48m

DTW

Nov 1

9:13pm

TYS

as low as

^$309

San Francisco, US (SFO) - Knoxville, US (TYS)

Nov 8

5:45am

SFO

12h 38m

MSP

Nov 8

6:23pm

TYS

as low as

^$309

San Francisco, US (SFO) - Knoxville, US (TYS)

Dec 4

6:00am

SFO

12h 13m

ATL

Dec 4

6:13pm

TYS

as low as

^$309

San Francisco, US (SFO) - Knoxville, US (TYS)

American Airlines

Sep 18

5:45am

SFO

9h 56m

DFW

Sep 18

3:41pm

TYS

as low as

^$357

San Francisco, US (SFO) - Knoxville, US (TYS)

Nov 7

5:45am

SFO

11h 17m

MSP

Nov 7

5:02pm

TYS

as low as

^$379

Frequently Asked Questions

What is the cheapest and fastest flight from San Francisco to Knoxville?

The cheapest and fastest flight is from Norman Y. Mineta San Jose International to McGhee Tyson Airport with American Airlines for $399, with a flight time of 6 hours 41 minutes.

What are all possible destination arrival airports?

The possible destination arrival airport is McGhee Tyson Airport in Knoxville.

What is the time difference between destination and arrival?

Your flight duration from San Francisco to Knoxville varies from 6 hours 41 minutes to 7 hours 13 minutes, depending on the chosen flight. Ensure to consider any time zone changes during your travel.

Is there a direct flight from San Francisco to Knoxville?

There is no direct flight from San Francisco to Knoxville. The cheapest option is a 1 stop flight with American Airlines for $399, which includes a layover at Dallas Fort Worth International Airport.

Are there convenient layover flights from San Francisco to Knoxville?

Yes, there are convenient layover flights available. American Airlines offers a 1 stop flight at $399, United Airlines has a 1 stop flight at $399, and Alaska Airlines offers a 1 stop flight at $408.

What are the most convenient layover airports for my flight?

The most convenient layover airports for your flight include Dallas Fort Worth International Airport and Denver International Airport with American Airlines and United Airlines, respectively.

Flights to Knoxville

Top Destinations

Origins

Return flights

Cabin Class

Flights
North America
United States
California
San Francisco

➔ Flights From Knoxville To San Francisco

➔ Business Class Flights From San Francisco To Knoxville

Flight Deals from San Francisco to Knoxville from $154

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from San Francisco to Knoxville

Frequently Asked Questions

Flights to Knoxville