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Flight Deals from Knoxville to San Diego from $294

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Bundle + Save

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Stops

  • Up to 1 stop
    $366

Airlines

  • Alaska Airlines
    $366
  • American Airlines
    $366
  • United Airlines
    $581

Cabin Class

  • Economy
    $366

Departure Airports

  • McGhee Tyson Airport
    $366

Arrival Airports

  • San Diego International Airport
    $366

Layover Airports

  • Charlotte Douglas International Airport
    $468
  • Chicago O Hare Airport
    $366
  • Dallas Fort Worth International Airport
    $366
  • Denver International Airport
    $581
  • George Bush Intercontinental Houston Airport
    $581
  • Washington Dulles Airport
    $581

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE
Book a flight & hotel together for extra savings.
On average save $240 per traveler
Alaska Airlines Logo
Alaska Airlines

09/10/25

TYS
9h 13m
DFW

09/10/25

SAN
Alaska Airlines Logo
Alaska Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
Alaska Airlines Logo
Alaska Airlines

09/10/25

TYS
6h 43m
DFW

09/10/25

SAN
Alaska Airlines Logo
Alaska Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
9h 13m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
6h 52m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
Alaska Airlines Logo
Alaska Airlines

09/10/25

TYS
6h 56m
DFW

09/10/25

SAN
Alaska Airlines Logo
Alaska Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
8h 59m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
6h 56m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
Alaska Airlines Logo
Alaska Airlines

09/10/25

TYS
6h 52m
DFW

09/10/25

SAN
Alaska Airlines Logo
Alaska Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
6h 43m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
Alaska Airlines Logo
Alaska Airlines

09/10/25

TYS
8h 59m
DFW

09/10/25

SAN
Alaska Airlines Logo
Alaska Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
8h 13m
ORD

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$366
American Airlines Logo
American Airlines

09/10/25

TYS
9h 36m
ORD

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$418
Alaska Airlines Logo
Alaska Airlines

09/10/25

TYS
7h 12m
DFW

09/10/25

SAN
Alaska Airlines Logo
Alaska Airlines

09/17/25

SAN
6h 20m
DFW

09/18/25

TYS
$418
American Airlines Logo
American Airlines

09/10/25

TYS
6h 52m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 5m
CLT

09/18/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
8h 59m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 5m
CLT

09/18/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
8h 13m
ORD

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 26m
DFW

09/17/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
6h 56m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 5m
CLT

09/18/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
8h 13m
ORD

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 5m
CLT

09/18/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
6h 43m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 5m
CLT

09/18/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
9h 13m
DFW

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 5m
CLT

09/18/25

TYS
$468
American Airlines Logo
American Airlines

09/10/25

TYS
8h 13m
ORD

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
7h 46m
DFW

09/17/25

TYS
$492
American Airlines Logo
American Airlines

09/10/25

TYS
9h 36m
ORD

09/10/25

SAN
American Airlines Logo
American Airlines

09/17/25

SAN
6h 26m
DFW

09/17/25

TYS
$520
United Airlines Logo
United Airlines

09/10/25

TYS
7h 24m
IAH

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 22m
IAD

09/17/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
7h 40m
ORD

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 22m
IAD

09/17/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
9h 34m
IAH

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 43m
ORD

09/18/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
6h 35m
IAH

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 22m
IAD

09/17/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
6h 45m
DEN

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 43m
ORD

09/18/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
8h 34m
DEN

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 22m
IAD

09/17/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
7h 24m
IAH

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 43m
ORD

09/18/25

TYS
$581
United Airlines Logo
United Airlines

09/10/25

TYS
8h 34m
DEN

09/10/25

SAN
United Airlines Logo
United Airlines

09/17/25

SAN
8h 43m
ORD

09/18/25

TYS
$581

Top Deals on flights from Knoxville to San Diego

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Oct 1

TYS
6h 6m
MSP

Oct 1

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Nov 25

TYS
6h 23m
DTW

Nov 25

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Sep 10

TYS
3h 7m
ATL

Sep 10

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Sep 16

TYS
3h 14m
ATL

Sep 16

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Sep 17

TYS
4h 18m
ATL

Sep 17

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Dec 2

TYS
6h 56m
DTW

Dec 2

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Sep 9

TYS
6h 12m
MSP

Sep 9

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Dec 3

TYS
4h 48m
ATL

Dec 3

SAN

as low as

$294

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Nov 27

TYS
6h 13m
MSP

Nov 27

SAN

as low as

$300

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Nov 7

TYS
6h 47m
DTW

Nov 7

SAN

as low as

$300

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Oct 25

TYS
6h 15m
MSP

Oct 25

SAN

as low as

$300

Knoxville, US (TYS) - San Diego, US (SAN)

 Logo

Sep 26

TYS
5h 35m
DTW

Sep 26

SAN

as low as

$300

Frequently Asked Questions

What is the time difference between destination and arrival?
The time difference between Knoxville, TN, and San Diego, CA, is two hours, with San Diego being two hours behind Knoxville.
Is there a direct flight from Knoxville to San Diego?
There is no direct flight from Knoxville to San Diego. The available options are 1 stop flights with American Airlines at $366, Alaska Airlines at $366, and United Airlines at $581.
Are there convenient layover flights from Knoxville to San Diego?
Yes, convenient 1 stop flights are available from Knoxville to San Diego with American Airlines at $366, Alaska Airlines at $366, and United Airlines at $581.
What are the most convenient layover airports for the flight?
The most convenient layover airports for your flight from Knoxville to San Diego are Dallas Fort Worth International Airport and George Bush Intercontinental Houston Airport.
What are the cheapest and fastest flights from Knoxville to San Diego?
The cheapest flight is with American Airlines for $366, taking 6 hours 43 minutes. The fastest flight is with United Airlines for $581, taking 6 hours 35 minutes.
What are all possible destination arrival airports?
The possible destination arrival airport is San Diego International Airport. Layovers may occur at Dallas Fort Worth International Airport and George Bush Intercontinental Houston Airport.