$728 Business Class Flight Deals from Knoxville to San Diego

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Stops

Up to 1 stop
$1066

Airlines

Alaska Airlines
$1206
American Airlines
$1066

Cabin Class

First
$1066

Departure Airports

McGhee Tyson Airport
$1066

Arrival Airports

San Diego International Airport
$1066

Layover Airports

Charlotte Douglas International Airport
$1066
Chicago O Hare Airport
$1266
Dallas Fort Worth International Airport
$1066

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

American Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

American Airlines

10/04/25

7:00am

SAN

9h 5m

CLT

10/04/25

7:05pm

TYS

^$1066

American Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

American Airlines

10/04/25

7:00am

SAN

6h 49m

CLT

10/04/25

4:49pm

TYS

^$1066

American Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

American Airlines

10/04/25

7:00am

SAN

9h 5m

CLT

10/04/25

7:05pm

TYS

^$1066

American Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

American Airlines

10/04/25

7:00am

SAN

6h 49m

CLT

10/04/25

4:49pm

TYS

^$1066

American Airlines

09/27/25

4:37pm

TYS

8h 59m

DFW

09/27/25

10:36pm

SAN

American Airlines

10/04/25

7:00am

SAN

6h 49m

CLT

10/04/25

4:49pm

TYS

^$1168

American Airlines

09/27/25

4:37pm

TYS

8h 59m

DFW

09/27/25

10:36pm

SAN

American Airlines

10/04/25

7:00am

SAN

9h 5m

CLT

10/04/25

7:05pm

TYS

^$1168

American Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

American Airlines

10/04/25

6:15am

SAN

6h 26m

DFW

10/04/25

3:41pm

TYS

^$1168

American Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

American Airlines

10/04/25

6:15am

SAN

6h 26m

DFW

10/04/25

3:41pm

TYS

^$1168

Alaska Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

Alaska Airlines

10/04/25

3:01pm

SAN

6h 20m

DFW

10/05/25

12:21am

TYS

^$1206

Alaska Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

Alaska Airlines

10/04/25

3:01pm

SAN

6h 20m

DFW

10/05/25

12:21am

TYS

^$1206

American Airlines

09/27/25

6:24pm

TYS

7h 12m

DFW

09/27/25

10:36pm

SAN

American Airlines

10/04/25

7:00am

SAN

9h 5m

CLT

10/04/25

7:05pm

TYS

^$1218

American Airlines

09/27/25

6:24pm

TYS

7h 12m

DFW

09/27/25

10:36pm

SAN

American Airlines

10/04/25

7:00am

SAN

6h 49m

CLT

10/04/25

4:49pm

TYS

^$1218

Alaska Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

Alaska Airlines

10/04/25

12:38pm

SAN

8h 43m

DFW

10/05/25

12:21am

TYS

^$1238

Alaska Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

Alaska Airlines

10/04/25

12:38pm

SAN

8h 43m

DFW

10/05/25

12:21am

TYS

^$1238

Alaska Airlines

09/27/25

6:00am

TYS

9h 3m

DFW

09/27/25

12:03pm

SAN

Alaska Airlines

10/04/25

3:01pm

SAN

6h 20m

DFW

10/05/25

12:21am

TYS

^$1238

Alaska Airlines

09/27/25

4:37pm

TYS

8h 59m

DFW

09/27/25

10:36pm

SAN

Alaska Airlines

10/04/25

3:01pm

SAN

6h 20m

DFW

10/05/25

12:21am

TYS

^$1238

American Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

American Airlines

10/04/25

6:15am

SAN

7h 4m

ORD

10/04/25

4:19pm

TYS

^$1266

American Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

American Airlines

10/04/25

6:15am

SAN

7h 4m

ORD

10/04/25

4:19pm

TYS

^$1266

Alaska Airlines

09/27/25

6:00am

TYS

9h 3m

DFW

09/27/25

12:03pm

SAN

Alaska Airlines

10/04/25

12:38pm

SAN

8h 43m

DFW

10/05/25

12:21am

TYS

^$1270

American Airlines

09/27/25

4:37pm

TYS

8h 59m

DFW

09/27/25

10:36pm

SAN

American Airlines

10/04/25

6:15am

SAN

6h 26m

DFW

10/04/25

3:41pm

TYS

^$1270

Alaska Airlines

09/27/25

4:37pm

TYS

8h 59m

DFW

09/27/25

10:36pm

SAN

Alaska Airlines

10/04/25

12:38pm

SAN

8h 43m

DFW

10/05/25

12:21am

TYS

^$1270

Alaska Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

Alaska Airlines

10/04/25

12:38pm

SAN

6h 38m

DFW

10/04/25

10:16pm

TYS

^$1288

Alaska Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

Alaska Airlines

10/04/25

12:38pm

SAN

6h 38m

DFW

10/04/25

10:16pm

TYS

^$1288

Alaska Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

Alaska Airlines

10/04/25

11:30am

SAN

7h 46m

DFW

10/04/25

10:16pm

TYS

^$1288

Alaska Airlines

09/27/25

6:24pm

TYS

7h 12m

DFW

09/27/25

10:36pm

SAN

Alaska Airlines

10/04/25

3:01pm

SAN

6h 20m

DFW

10/05/25

12:21am

TYS

^$1288

Alaska Airlines

09/27/25

4:37pm

TYS

6h 43m

DFW

09/27/25

8:20pm

SAN

Alaska Airlines

10/04/25

7:13am

SAN

7h 41m

DFW

10/04/25

5:54pm

TYS

^$1288

Alaska Airlines

09/27/25

6:00am

TYS

6h 52m

DFW

09/27/25

9:52am

SAN

Alaska Airlines

10/04/25

7:13am

SAN

7h 41m

DFW

10/04/25

5:54pm

TYS

^$1288

American Airlines

09/27/25

6:24pm

TYS

7h 12m

DFW

09/27/25

10:36pm

SAN

American Airlines

10/04/25

6:15am

SAN

6h 26m

DFW

10/04/25

3:41pm

TYS

^$1320

Top Deals on flights Business Class from Knoxville to San Diego

Knoxville, US (TYS) - San Diego, US (SAN)

American Airlines

Sep 28

5:30am

TYS

7h 31m

DFW

Sep 28

10:01am

SAN

as low as

^$728

Knoxville, US (TYS) - San Diego, US (SAN)

Alaska Airlines

Sep 28

5:30am

TYS

7h 31m

DFW

Sep 28

10:01am

SAN

as low as

^$728

Knoxville, US (TYS) - San Diego, US (SAN)

American Airlines

Sep 28

5:30am

TYS

30h 23m

DFW

PHX

Sep 29

8:53am

SAN

as low as

^$959

Knoxville, US (TYS) - San Diego, US (SAN)

American Airlines

Sep 28

5:30am

TYS

43h 22m

DFW

PHX

Sep 29

9:52pm

SAN

as low as

^$959

Knoxville, US (TYS) - San Diego, US (SAN)

Alaska Airlines

Sep 28

2:07pm

TYS

6h 55m

DFW

Sep 28

6:02pm

SAN

as low as

^$1035

Knoxville, US (TYS) - San Diego, US (SAN)

Alaska Airlines

Sep 28

7:30am

TYS

7h 33m

DFW

Sep 28

12:03pm

SAN

as low as

^$1035

Frequently Asked Questions

What are all possible destination arrival airports?

The possible destination arrival airport is San Diego International Airport, with layovers at Dallas Fort Worth International Airport.

What is the time difference between destination and arrival?

When flying from Knoxville to San Diego, you'll experience a time difference of two hours, as San Diego is two hours behind Knoxville.

Is there a direct flight from Knoxville to San Diego?

There is no direct flight from Knoxville to San Diego. The available flights are 1 stop, with American Airlines priced at $1066 and Alaska Airlines priced at $1206, both with layovers at Dallas Fort Worth International Airport.

Are there convenient layover flights from Knoxville to San Diego?

Yes, convenient layover flights from Knoxville to San Diego are available. American Airlines offers a 1 stop flight for $1066 with a flight time of 6 hours 52 minutes, and Alaska Airlines provides a 1 stop flight for $1206 with a flight time of 6 hours 43 minutes.

What are the most convenient layover airports for the flight?

For your flight from Knoxville to San Diego, convenient layover airports include Dallas Fort Worth (American Airlines), Los Angeles (Alaska Airlines), Denver (United Airlines), Atlanta (Delta Air Lines), and Chicago O'Hare (American Airlines).

What is the cheapest and fastest flight from Knoxville to San Diego?

The cheapest and fastest option is with American Airlines at $1066. The flight has 1 stop at Dallas Fort Worth International Airport, taking 6 hours 43 minutes.

Flights to San Diego

Top Destinations

Origins

Return flights

Cabin Class

➔ Business Class Flights From San Diego To Knoxville

➔ Flights From Knoxville To San Diego

Business Class Flight Deals from Knoxville to San Diego from $728

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights Business Class from Knoxville to San Diego

Frequently Asked Questions

Flights to San Diego