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Flight Deals from San Diego to Knoxville from $168

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Bundle + Save

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

  • Up to 2 stops
    $336
  • Up to 1 stop
    $436
  • Up to 3 stops
    $473

Airlines

  • Alaska Airlines
    $436
  • American Airlines
    $436
  • Delta Air Lines
    $336
  • United Airlines
    $436

Cabin Class

  • Economy
    $336

Departure Airports

  • San Diego International Airport
    $336

Arrival Airports

  • McGhee Tyson Airport
    $336

Layover Airports

  • Charlotte Douglas International Airport
    $640
  • Chicago O Hare Airport
    $436
  • Dallas Fort Worth International Airport
    $436
  • Denver International Airport
    $468
  • Detroit Metropolitan Airport
    $336
  • George Bush Intercontinental Houston Airport
    $533
  • Hartsfield Jackson Atlanta International Airport
    $336
  • Los Angeles International Airport
    $473
  • Mc Clellan-Palomar Airport
    $468
  • McGhee Tyson Airport
    $336
  • Minneapolis-St Paul International/Wold-Chamberlain Airport
    $615
  • San Diego International Airport
    $336
  • Seattle Tacoma International Airport
    $611

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
We'll refund the difference if you find a lower price.

Delta Air Lines Logo
Delta Air Lines

05/24/26

SAN
9h 52m
DTW
TYS

05/24/26

TYS
Delta Air Lines Logo
Delta Air Lines

05/29/26

TYS
3h 49m
ATL
SAN

05/29/26

SAN
$336
Alaska Airlines Logo
Alaska Airlines

05/24/26

SAN
10h 56m
DFW
TYS

05/24/26

TYS
Alaska Airlines Logo
Alaska Airlines

05/29/26

TYS
6h 31m
DFW
SAN

05/29/26

SAN
$436
United Airlines Logo
United Airlines

05/24/26

SAN
10h 20m
ORD
TYS

05/24/26

TYS
United Airlines Logo
United Airlines

05/29/26

TYS
4h 51m
ORD
SAN

05/29/26

SAN
$436
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
American Airlines Logo
American Airlines

05/24/26

SAN
9h 37m
DFW
TYS

05/24/26

TYS
American Airlines Logo
American Airlines

05/29/26

TYS
3h 44m
DFW
SAN

05/29/26

SAN
$436
Alaska Airlines Logo
Alaska Airlines

05/24/26

SAN
7h 56m
DFW

05/24/26

TYS
Alaska Airlines Logo
Alaska Airlines

05/29/26

TYS
9h 31m
DFW

05/29/26

SAN
$436
Delta Air Lines Logo
Delta Air Lines

05/27/26

SAN
10h 11m
ATL
TYS

05/28/26

TYS
Delta Air Lines Logo
Delta Air Lines

06/03/26

TYS
3h 49m
ATL
SAN

06/03/26

SAN
$438
Delta Air Lines Logo
Delta Air Lines

05/23/26

SAN
9h 52m
DTW
TYS

05/23/26

TYS
Delta Air Lines Logo
Delta Air Lines

05/27/26

TYS
3h 54m
ATL
SAN

05/27/26

SAN
$438
Delta Air Lines Logo
Delta Air Lines

05/29/26

SAN
10h 6m
ATL
TYS

05/29/26

TYS
Delta Air Lines Logo
Delta Air Lines

06/05/26

TYS
3h 54m
ATL
SAN

06/05/26

SAN
$456
United Airlines Logo
United Airlines

05/24/26

SAN
9h 23m
TYS

05/24/26

TYS
United Airlines Logo
United Airlines

05/29/26

TYS
4h 51m
ORD
SAN

05/29/26

SAN
$462
United Airlines Logo
United Airlines

05/27/26

SAN
10h 1m
ORD
TYS

05/28/26

TYS
United Airlines Logo
United Airlines

06/01/26

TYS
3h 47m
DEN
CLD

06/01/26

SAN
$468
United Airlines Logo
United Airlines

05/27/26

SAN
13h 20m
LAX
ORD
TYS

05/28/26

TYS
United Airlines Logo
United Airlines

06/01/26

TYS
3h 47m
DEN
CLD

06/01/26

SAN
$473
United Airlines Logo
United Airlines

06/04/26

SAN
9h 27m
DEN
TYS

06/04/26

TYS
United Airlines Logo
United Airlines

06/09/26

TYS
4h 12m
DEN
CLD

06/09/26

SAN
$483
United Airlines Logo
United Airlines

06/05/26

SAN
9h 27m
DEN
TYS

06/05/26

TYS
United Airlines Logo
United Airlines

06/11/26

TYS
3h 47m
DEN
CLD

06/11/26

SAN
$483
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
Delta Air Lines Logo
Delta Air Lines

05/28/26

SAN
12h 6m
DTW
TYS

05/29/26

TYS
Delta Air Lines Logo
Delta Air Lines

06/04/26

TYS
3h 54m
ATL
SAN

06/04/26

SAN
$487
United Airlines Logo
United Airlines

05/23/26

SAN
9h 23m
TYS

05/23/26

TYS
United Airlines Logo
United Airlines

05/27/26

TYS
4h 25m
IAH
SAN

05/27/26

SAN
$533
United Airlines Logo
United Airlines

05/23/26

SAN
10h 11m
ORD
TYS

05/23/26

TYS
United Airlines Logo
United Airlines

05/27/26

TYS
4h 25m
IAH
SAN

05/27/26

SAN
$538
American Airlines Logo
American Airlines

05/23/26

SAN
9h 37m
DFW
TYS

05/23/26

TYS
American Airlines Logo
American Airlines

05/27/26

TYS
3h 58m
DFW
SAN

05/27/26

SAN
$538
Alaska Airlines Logo
Alaska Airlines

05/26/26

SAN
9h 43m
DFW
TYS

05/26/26

TYS
Alaska Airlines Logo
Alaska Airlines

05/28/26

TYS
6h 31m
DFW
SAN

05/28/26

SAN
$538
Alaska Airlines Logo
Alaska Airlines

05/23/26

SAN
10h 56m
DFW
TYS

05/23/26

TYS
Alaska Airlines Logo
Alaska Airlines

05/27/26

TYS
6h 31m
DFW
SAN

05/27/26

SAN
$538
Delta Air Lines Logo
Delta Air Lines

06/02/26

SAN
9h 52m
DTW
TYS

06/02/26

TYS
Delta Air Lines Logo
Delta Air Lines

06/06/26

TYS
4h 3m
ATL
SAN

06/06/26

SAN
$540
American Airlines Logo
American Airlines

06/06/26

SAN
10h 58m
DFW
TYS

06/06/26

TYS
American Airlines Logo
American Airlines

06/10/26

TYS
5h 6m
DFW
SAN

06/10/26

SAN
$548
American Airlines Logo
American Airlines

05/27/26

SAN
9h 37m
DFW
TYS

05/27/26

TYS
American Airlines Logo
American Airlines

06/01/26

TYS
3h 48m
DFW
SAN

06/01/26

SAN
$556
Alaska Airlines Logo
Alaska Airlines

05/27/26

SAN
10h 56m
DFW
TYS

05/27/26

TYS
Alaska Airlines Logo
Alaska Airlines

06/01/26

TYS
9h 12m
ORD
SEA
SAN

06/01/26

SAN
$611
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
Delta Air Lines Logo
Delta Air Lines

06/05/26

SAN
11h 49m
DTW
TYS

06/06/26

TYS
Delta Air Lines Logo
Delta Air Lines

06/12/26

TYS
3h 58m
MSP
SAN

06/12/26

SAN
$615
American Airlines Logo
American Airlines

06/02/26

SAN
10h 26m
CLT
TYS

06/02/26

TYS
American Airlines Logo
American Airlines

06/06/26

TYS
3h 48m
DFW
SAN

06/06/26

SAN
$640
Alaska Airlines Logo
Alaska Airlines

05/23/26

SAN
10h 56m
DFW
TYS

05/23/26

TYS
Alaska Airlines Logo
Alaska Airlines

05/27/26

TYS
9h 11m
ORD
SEA
SAN

05/27/26

SAN
$645
Alaska Airlines Logo
Alaska Airlines

05/30/26

SAN
10h 56m
DFW
TYS

05/30/26

TYS
Alaska Airlines Logo
Alaska Airlines

06/03/26

TYS
9h 11m
ORD
SEA
SAN

06/03/26

SAN
$645
Alaska Airlines Logo
Alaska Airlines

05/26/26

SAN
9h 43m
DFW
TYS

05/26/26

TYS
Alaska Airlines Logo
Alaska Airlines

05/28/26

TYS
9h 11m
ORD
SEA
SAN

05/28/26

SAN
$674
United Airlines Logo
United Airlines

06/01/26

SAN
13h 11m
LAX
ORD
TYS

06/02/26

TYS
United Airlines Logo
United Airlines

06/05/26

TYS
3h 53m
DEN
SAN

06/05/26

SAN
$681
American Airlines Logo
American Airlines

06/01/26

SAN
9h 28m
DFW
TYS

06/01/26

TYS
American Airlines Logo
American Airlines

06/05/26

TYS
12h 23m
CLT
DFW
SAN

06/06/26

SAN
$995

Top Deals on flights from San Diego to Knoxville

San Diego, US (SAN) - Knoxville, US (TYS)

Delta Air Lines Logo
Delta Air Lines

Oct 6

SAN
9h 54m
DTW
TYS

Oct 6

TYS

as low as

$168

San Diego, US (SAN) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Oct 6

SAN
8h 10m
MIA

Oct 6

TYS

as low as

$218

San Diego, US (SAN) - Knoxville, US (TYS)

United Airlines Logo
United Airlines

May 28

SAN
7h 57m
IAD

May 28

TYS

as low as

$218

San Diego, US (SAN) - Knoxville, US (TYS)

Alaska Airlines Logo
Alaska Airlines

Oct 6

SAN
12h 34m
DFW
TYS

Oct 6

TYS

as low as

$218

San Diego, US (SAN) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Oct 6

SAN
11h 20m
DFW
TYS

Oct 6

TYS

as low as

$218

San Diego, US (SAN) - Knoxville, US (TYS)

Alaska Airlines Logo
Alaska Airlines

Oct 6

SAN
9h 34m
DFW

Oct 6

TYS

as low as

$218

San Diego, US (SAN) - Knoxville, US (TYS)

United Airlines Logo
United Airlines

Oct 6

SAN
12h 51m
IAD
TYS

Oct 7

TYS

as low as

$387

San Diego, US (SAN) - Knoxville, US (TYS)

Alaska Airlines Logo
Alaska Airlines

Oct 1

SAN
11h 50m
DFW
TYS

Oct 1

TYS

as low as

$423

Good to Know

Essential information to help you plan your flight from San Diego to Knoxville

Cheapest Flight

$168

The lowest price we found in the last two weeks, departing Oct 6 and returning Oct 6

Airline DL2 stops ‧ 9h 54m ‧ economy

Fastest Flights

$436

The fastest flight that we found in the last two weeks, departing May 24 and returning May 29

Airline AS1 stop ‧ 7h 56m ‧ economy

Cheapest Flight Round-trip

$336

Cheapest price found in the last 14 days, departing May 24 and returning May 29

Airline DL2 stops ‧ 9h 52m ‧ economy

Cheapest Flight One-way

$168

Cheapest price found in the last 14 days, departing Oct 6

Airline DL2 stops ‧ 9h 54m ‧ economy

Cheapest Layover airport

$168

The cheapest layover airport to Knoxville is currently $168

Airline DL2 stops ‧ 9h 54m ‧ economy

Best Arrival airport

$168

The best arrival airport to Knoxville is currently $168

Airline DL2 stops ‧ 9h 54m ‧ economy

Best Departure airport

$168

The best departure airport to Knoxville is currently $168

Airline DL2 stops ‧ 9h 54m ‧ economy

Cheapest Airline

$168

The cheapest airline to Knoxville is currently $168

Airline DL2 stops ‧ 9h 54m ‧ economy

Flights to Knoxville