$266 Flight Deals from Knoxville to Detroit

Top flight deals from leading airlines:

... and +100s more

Incredible Deals

Save up to 50% on select flights with Priceline

Bundle & Save

Save an average of $240 per person when bundling your flight and hotel together with Priceline

Best Price Guarantee

If a VIP member finds a better price elsewhere, we'll refund up to 200% of the difference

Help 24/7

We’re always here for you - reach us 24 hours a day, 7 days a week

Stops

Up to 1 stop
$266

Airlines

American Airlines
$378
Frontier Airlines
$266
United Airlines
$398

Cabin Class

Economy
$266

Departure Airports

McGhee Tyson Airport
$266

Arrival Airports

Detroit Metropolitan Airport
$266

Layover Airports

Charlotte Douglas International Airport
$378
Chicago O Hare Airport
$398
Denver International Airport
$266
Philadelphia International Airport
$378
Washington Dulles Airport
$398

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
We'll refund the difference if you find a lower price.

BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

Frontier Airlines

09/28/25

5:08pm

TYS

7h 38m

DEN

09/29/25

12:46am

DTW

Frontier Airlines

10/05/25

6:10am

DTW

10h 8m

DEN

10/05/25

4:18pm

TYS

^$266

American Airlines

09/28/25

8:36pm

TYS

4h 7m

CLT

09/29/25

12:43am

DTW

American Airlines

10/05/25

8:00am

DTW

4h 23m

CLT

10/05/25

12:23pm

TYS

^$378

American Airlines

09/28/25

5:05am

TYS

4h 18m

CLT

09/28/25

9:23am

DTW

American Airlines

10/05/25

8:00am

DTW

4h 23m

CLT

10/05/25

12:23pm

TYS

^$378

American Airlines

09/28/25

6:30am

TYS

4h 37m

CLT

09/28/25

11:07am

DTW

American Airlines

10/05/25

8:00am

DTW

4h 23m

CLT

10/05/25

12:23pm

TYS

^$378

American Airlines

09/28/25

6:30am

TYS

4h 37m

CLT

09/28/25

11:07am

DTW

American Airlines

10/05/25

6:00am

DTW

4h 32m

CLT

10/05/25

10:32am

TYS

^$378

American Airlines

09/28/25

8:36pm

TYS

4h 7m

CLT

09/29/25

12:43am

DTW

American Airlines

10/05/25

6:00am

DTW

4h 32m

CLT

10/05/25

10:32am

TYS

^$378

American Airlines

09/28/25

7:18am

TYS

5h 50m

PHL

09/28/25

1:08pm

DTW

American Airlines

10/05/25

8:00am

DTW

4h 23m

CLT

10/05/25

12:23pm

TYS

^$378

American Airlines

09/28/25

8:36pm

TYS

4h 7m

CLT

09/29/25

12:43am

DTW

American Airlines

10/05/25

8:00am

DTW

5h 54m

CLT

10/05/25

1:54pm

TYS

^$378

American Airlines

09/28/25

5:05am

TYS

4h 18m

CLT

09/28/25

9:23am

DTW

American Airlines

10/05/25

6:00am

DTW

4h 32m

CLT

10/05/25

10:32am

TYS

^$378

American Airlines

09/28/25

5:05am

TYS

4h 18m

CLT

09/28/25

9:23am

DTW

American Airlines

10/05/25

8:00am

DTW

5h 54m

CLT

10/05/25

1:54pm

TYS

^$378

United Airlines

09/28/25

7:00am

TYS

6h 7m

ORD

09/28/25

1:07pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 29m

IAD

10/05/25

10:29am

TYS

^$398

United Airlines

09/28/25

7:00am

TYS

6h 7m

ORD

09/28/25

1:07pm

DTW

United Airlines

10/05/25

6:05pm

DTW

4h 45m

ORD

10/05/25

10:50pm

TYS

^$417

American Airlines

09/28/25

6:08pm

TYS

4h 21m

CLT

09/28/25

10:29pm

DTW

American Airlines

10/05/25

6:00am

DTW

4h 32m

CLT

10/05/25

10:32am

TYS

^$417

United Airlines

09/28/25

7:00am

TYS

6h 7m

ORD

09/28/25

1:07pm

DTW

United Airlines

10/05/25

4:20pm

DTW

6h 30m

ORD

10/05/25

10:50pm

TYS

^$417

American Airlines

09/28/25

6:08pm

TYS

4h 21m

CLT

09/28/25

10:29pm

DTW

American Airlines

10/05/25

8:00am

DTW

4h 23m

CLT

10/05/25

12:23pm

TYS

^$417

United Airlines

09/28/25

7:00am

TYS

6h 7m

ORD

09/28/25

1:07pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 10m

ORD

10/05/25

10:10am

TYS

^$453

United Airlines

09/28/25

7:00am

TYS

16h 41m

ORD

09/28/25

11:41pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 29m

IAD

10/05/25

10:29am

TYS

^$456

United Airlines

09/28/25

7:00am

TYS

8h 33m

ORD

09/28/25

3:33pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 29m

IAD

10/05/25

10:29am

TYS

^$456

United Airlines

09/28/25

7:00am

TYS

8h 33m

ORD

09/28/25

3:33pm

DTW

United Airlines

10/05/25

6:05pm

DTW

4h 45m

ORD

10/05/25

10:50pm

TYS

^$475

United Airlines

09/28/25

7:00am

TYS

8h 33m

ORD

09/28/25

3:33pm

DTW

United Airlines

10/05/25

4:20pm

DTW

6h 30m

ORD

10/05/25

10:50pm

TYS

^$475

American Airlines

09/28/25

11:17am

TYS

4h 1m

CLT

09/28/25

3:18pm

DTW

American Airlines

10/05/25

8:00am

DTW

4h 23m

CLT

10/05/25

12:23pm

TYS

^$488

American Airlines

09/28/25

8:36pm

TYS

4h 7m

CLT

09/29/25

12:43am

DTW

American Airlines

10/05/25

11:35am

DTW

4h 28m

CLT

10/05/25

4:03pm

TYS

^$488

United Airlines

09/28/25

7:00am

TYS

6h 7m

ORD

09/28/25

1:07pm

DTW

United Airlines

10/05/25

9:15am

DTW

11h 25m

ORD

10/05/25

8:40pm

TYS

^$490

United Airlines

09/28/25

7:00am

TYS

8h 33m

ORD

09/28/25

3:33pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 10m

ORD

10/05/25

10:10am

TYS

^$512

United Airlines

09/28/25

7:00am

TYS

6h 7m

ORD

09/28/25

1:07pm

DTW

United Airlines

10/05/25

9:15am

DTW

4h 10m

ORD

10/05/25

1:25pm

TYS

^$517

United Airlines

09/28/25

7:00am

TYS

9h 51m

ORD

09/28/25

4:51pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 29m

IAD

10/05/25

10:29am

TYS

^$536

United Airlines

09/28/25

7:00am

TYS

13h 26m

ORD

09/28/25

8:26pm

DTW

United Airlines

10/05/25

6:00am

DTW

4h 29m

IAD

10/05/25

10:29am

TYS

^$566

Top Deals on flights from Knoxville to Detroit

Knoxville, US (TYS) - Detroit, US (DTT)

Dec 5

11:30am

TYS

1h 45m

Direct

Dec 5

1:15pm

DTW

as low as

^$288

Knoxville, US (TYS) - Detroit, US (DTT)

Jan 5

7:30am

TYS

1h 46m

Direct

Jan 5

9:16am

DTW

as low as

^$288

Knoxville, US (TYS) - Detroit, US (DTT)

Nov 6

12:47pm

TYS

1h 43m

Direct

Nov 6

2:30pm

DTW

as low as

^$288

Knoxville, US (TYS) - Detroit, US (DTT)

Sep 30

6:08pm

TYS

6h 16m

ATL

Oct 1

12:24am

DTW

as low as

^$298

Knoxville, US (TYS) - Detroit, US (DTT)

Jan 5

5:00pm

TYS

5h 13m

LGA

Jan 5

10:13pm

DTW

as low as

^$298

Knoxville, US (TYS) - Detroit, US (DTT)

Oct 28

11:44am

TYS

4h 44m

LGA

Oct 28

4:28pm

DTW

as low as

^$298

Knoxville, US (TYS) - Detroit, US (DTT)

Oct 31

3:56pm

TYS

4h 46m

ATL

Oct 31

8:42pm

DTW

as low as

^$298

Knoxville, US (TYS) - Detroit, US (DTT)

Jan 20

5:00pm

TYS

5h 13m

LGA

Jan 20

10:13pm

DTW

as low as

^$298

Knoxville, US (TYS) - Detroit, US (DTT)

Nov 6

5:16pm

TYS

4h 26m

ATL

Nov 6

9:42pm

DTW

as low as

^$298

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines

Sep 5

3:13pm

TYS

8h 8m

ORD

Sep 5

11:21pm

DTW

as low as

^$357

Knoxville, US (TYS) - Detroit, US (DTT)

United Airlines

Sep 5

9:30am

TYS

6h 37m

IAH

Sep 5

4:07pm

DTW

as low as

^$388

Knoxville, US (TYS) - Detroit, US (DTT)

United Airlines

Sep 2

5:35pm

TYS

4h 47m

ORD

Sep 2

10:22pm

DTW

as low as

^$538

Frequently Asked Questions

Are there convenient layover flights from Knoxville to Detroit?

Yes, convenient 1 stop flights are available from Knoxville to Detroit. Frontier Airlines offers a flight for $266, American Airlines for $378, and United Airlines for $398.

What are the most convenient layover airports for the flight?

For your flight, the most convenient layover airports are Denver International Airport with Frontier Airlines, Charlotte Douglas International Airport with American Airlines, and Chicago O'Hare Airport with United Airlines.

What are the cheapest and fastest flights from Knoxville to Detroit?

The cheapest flight is with Frontier Airlines for $266, taking 7 hours 38 minutes. The fastest flight is with American Airlines for $488, taking 4 hours 1 minute.

What are all possible destination arrival airports?

The possible destination arrival airports are Detroit Metropolitan Airport, along with layover airports including Denver International Airport, Charlotte Douglas International Airport, and Chicago O'Hare Airport.

What is the time difference between destination and arrival?

The time difference between Knoxville and Detroit is one hour, with Detroit being one hour ahead.

Is there a direct flight from Knoxville to Detroit?

There is no direct flight from Knoxville to Detroit. The available options are 1 stop flights with Frontier Airlines at $266, American Airlines at $378, and United Airlines at $398.

Flights to Detroit

Top Destinations

Origins

Return flights

Cabin Class

Flight Deals from Knoxville to Detroit from $266

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Knoxville to Detroit

Frequently Asked Questions

Flights to Detroit