$243 Flight Deals from Detroit to Knoxville

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Stops

Up to 1 stop
$388

Airlines

American Airlines
$395
United Airlines
$388

Cabin Class

Economy
$388

Departure Airports

Detroit Metropolitan Airport
$388

Arrival Airports

McGhee Tyson Airport
$388

Layover Airports

Charlotte Douglas International Airport
$413
Chicago O Hare Airport
$388
Dallas Fort Worth International Airport
$438
New York LaGuardia Airport
$395
Philadelphia International Airport
$438
Reagan Washington National Airport
$438
Washington Dulles Airport
$413

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Exclusively for Priceline Members
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

United Airlines

08/13/25

2:10pm

DTW

8h 25m

ORD

08/13/25

10:35pm

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$388

American Airlines

08/13/25

10:24am

DTW

10h 45m

LGA

08/13/25

9:09pm

TYS

American Airlines

08/20/25

11:59am

TYS

4h 59m

LGA

08/20/25

4:58pm

DTW

^$395

American Airlines

08/13/25

6:15am

DTW

5h 14m

LGA

08/13/25

11:29am

TYS

American Airlines

08/20/25

11:59am

TYS

4h 59m

LGA

08/20/25

4:58pm

DTW

^$396

United Airlines

08/13/25

6:15pm

DTW

4h 20m

Direct

08/13/25

10:35pm

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$409

United Airlines

08/13/25

6:00am

DTW

4h 17m

ORD

08/13/25

10:17am

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$413

United Airlines

08/13/25

2:10pm

DTW

8h 25m

ORD

08/13/25

10:35pm

TYS

United Airlines

08/20/25

7:25pm

TYS

4h 34m

IAD

08/20/25

11:59pm

DTW

^$413

United Airlines

08/13/25

6:00am

DTW

4h 27m

IAD

08/13/25

10:27am

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$413

United Airlines

08/13/25

7:48pm

DTW

4h 11m

IAD

08/13/25

11:59pm

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$413

American Airlines

08/13/25

6:55am

DTW

7h 39m

ORD

08/13/25

2:34pm

TYS

American Airlines

08/20/25

12:03pm

TYS

3h 26m

CLT

08/20/25

3:29pm

DTW

^$413

American Airlines

08/13/25

6:55am

DTW

7h 39m

ORD

08/13/25

2:34pm

TYS

American Airlines

08/20/25

6:05am

TYS

3h 59m

CLT

08/20/25

10:04am

DTW

^$413

United Airlines

08/13/25

4:20pm

DTW

6h 15m

ORD

08/13/25

10:35pm

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$413

United Airlines

08/13/25

2:10pm

DTW

8h 25m

ORD

08/13/25

10:35pm

TYS

United Airlines

08/20/25

7:00am

TYS

6h 14m

ORD

08/20/25

1:14pm

DTW

^$413

United Airlines

08/13/25

2:10pm

DTW

8h 25m

ORD

08/13/25

10:35pm

TYS

United Airlines

08/20/25

10:54am

TYS

5h 57m

ORD

08/20/25

4:51pm

DTW

^$413

United Airlines

08/13/25

2:35pm

DTW

6h 22m

IAD

08/13/25

8:57pm

TYS

United Airlines

08/20/25

10:54am

TYS

11h 28m

ORD

08/20/25

10:22pm

DTW

^$413

American Airlines

08/13/25

10:24am

DTW

5h 49m

LGA

08/13/25

4:13pm

TYS

American Airlines

08/20/25

11:59am

TYS

4h 59m

LGA

08/20/25

4:58pm

DTW

^$416

United Airlines

08/13/25

6:15pm

DTW

4h 20m

Direct

08/13/25

10:35pm

TYS

United Airlines

08/20/25

7:25pm

TYS

4h 34m

IAD

08/20/25

11:59pm

DTW

^$433

American Airlines

08/13/25

5:24pm

DTW

4h 37m

DCA

08/13/25

10:01pm

TYS

American Airlines

08/20/25

7:55am

TYS

4h 37m

ORD

08/20/25

12:32pm

DTW

^$438

American Airlines

08/13/25

1:43pm

DTW

5h 11m

CLT

08/13/25

6:54pm

TYS

American Airlines

08/20/25

12:03pm

TYS

3h 26m

CLT

08/20/25

3:29pm

DTW

^$438

American Airlines

08/13/25

4:00pm

DTW

4h 55m

PHL

08/13/25

8:55pm

TYS

American Airlines

08/20/25

12:03pm

TYS

3h 26m

CLT

08/20/25

3:29pm

DTW

^$438

American Airlines

08/13/25

6:18pm

DTW

6h 1m

DFW

08/14/25

12:19am

TYS

American Airlines

08/20/25

12:03pm

TYS

3h 26m

CLT

08/20/25

3:29pm

DTW

^$438

American Airlines

08/13/25

4:00pm

DTW

4h 55m

PHL

08/13/25

8:55pm

TYS

American Airlines

08/20/25

6:05am

TYS

3h 59m

CLT

08/20/25

10:04am

DTW

^$438

American Airlines

08/13/25

6:00am

DTW

4h 6m

DCA

08/13/25

10:06am

TYS

American Airlines

08/20/25

7:55am

TYS

4h 37m

ORD

08/20/25

12:32pm

DTW

^$438

American Airlines

08/13/25

5:24pm

DTW

4h 37m

DCA

08/13/25

10:01pm

TYS

American Airlines

08/20/25

1:29pm

TYS

4h 5m

CLT

08/20/25

5:34pm

DTW

^$438

American Airlines

08/13/25

6:15am

DTW

5h 14m

LGA

08/13/25

11:29am

TYS

American Airlines

08/20/25

12:03pm

TYS

3h 26m

CLT

08/20/25

3:29pm

DTW

^$438

American Airlines

08/13/25

6:00am

DTW

4h 6m

DCA

08/13/25

10:06am

TYS

American Airlines

08/20/25

11:59am

TYS

4h 59m

LGA

08/20/25

4:58pm

DTW

^$438

American Airlines

08/13/25

6:00am

DTW

4h 6m

DCA

08/13/25

10:06am

TYS

American Airlines

08/20/25

1:29pm

TYS

4h 5m

CLT

08/20/25

5:34pm

DTW

^$438

American Airlines

08/13/25

6:00am

DTW

4h 6m

DCA

08/13/25

10:06am

TYS

American Airlines

08/20/25

10:10am

TYS

5h 19m

CLT

08/20/25

3:29pm

DTW

^$438

American Airlines

08/13/25

6:00am

DTW

4h 6m

DCA

08/13/25

10:06am

TYS

American Airlines

08/20/25

5:26pm

TYS

5h 4m

CLT

08/20/25

10:30pm

DTW

^$438

United Airlines

08/13/25

7:48pm

DTW

4h 11m

IAD

08/13/25

11:59pm

TYS

United Airlines

08/20/25

7:25pm

TYS

4h 34m

IAD

08/20/25

11:59pm

DTW

^$438

American Airlines

08/13/25

4:00pm

DTW

4h 55m

PHL

08/13/25

8:55pm

TYS

American Airlines

08/20/25

7:55am

TYS

4h 37m

ORD

08/20/25

12:32pm

DTW

^$438

Top Deals on flights from Detroit to Knoxville

Detroit, US (DTT) - Knoxville, US (TYS)

American Airlines

Aug 23

6:00am

DTW

10h 51m

DCA

Aug 23

4:51pm

TYS

as low as

^$243

Detroit, US (DTT) - Knoxville, US (TYS)

United Airlines

Sep 5

2:30pm

DTW

6h 26m

IAD

Sep 5

8:56pm

TYS

as low as

^$258

Detroit, US (DTT) - Knoxville, US (TYS)

United Airlines

Aug 29

5:54pm

DTW

4h 42m

ORD

Aug 29

10:36pm

TYS

as low as

^$258

Detroit, US (DTT) - Knoxville, US (TYS)

United Airlines

Oct 12

6:05pm

DTW

4h 45m

ORD

Oct 12

10:50pm

TYS

as low as

^$258

Detroit, US (DTT) - Knoxville, US (TYS)

United Airlines

Sep 18

6:00am

DTW

4h 28m

IAD

Sep 18

10:28am

TYS

as low as

^$258

Detroit, US (DTT) - Knoxville, US (TYS)

American Airlines

Oct 12

10:02am

DTW

4h 25m

CLT

Oct 12

2:27pm

TYS

as low as

^$263

Detroit, US (DTT) - Knoxville, US (TYS)

American Airlines

Sep 5

3:45pm

DTW

5h 29m

PHL

Sep 5

9:14pm

TYS

as low as

^$263

Detroit, US (DTT) - Knoxville, US (TYS)

American Airlines

Sep 18

6:00am

DTW

6h 36m

LGA

Sep 18

12:36pm

TYS

as low as

^$263

Detroit, US (DTT) - Knoxville, US (TYS)

American Airlines

Aug 29

4:00pm

DTW

4h 55m

PHL

Aug 29

8:55pm

TYS

as low as

^$263

Detroit, US (DTT) - Knoxville, US (TYS)

Nov 5

4:15pm

DTW

1h 37m

Direct

Nov 5

5:52pm

TYS

as low as

^$318

Detroit, US (DTT) - Knoxville, US (TYS)

Oct 22

7:55pm

DTW

1h 37m

Direct

Oct 22

9:32pm

TYS

as low as

^$318

Detroit, US (DTT) - Knoxville, US (TYS)

Nov 10

6:30am

DTW

4h 35m

ATL

Nov 10

11:05am

TYS

as low as

^$328

Frequently Asked Questions

What is the cheapest and fastest flight from Detroit to Knoxville?

The cheapest flight is with United Airlines for $388, taking 8 hours 25 minutes. The fastest option is with American Airlines for $438, taking 4 hours 6 minutes.

What are all possible destination arrival airports?

Possible destination arrival airports for your flight include McGhee Tyson Airport, with layovers at Chicago O'Hare Airport, Reagan Washington National Airport, and New York LaGuardia Airport.

What is the time difference between destination and arrival?

The time difference between Detroit and Knoxville is one hour, with Knoxville being one hour ahead of Detroit.

Is there a direct flight from Detroit to Knoxville?

Yes, there is a direct flight from Detroit Metropolitan Airport to McGhee Tyson Airport with United Airlines at a price of $409. The flight time is 4 hours and 20 minutes.

Are there convenient layover flights from Detroit to Knoxville?

Yes, there are convenient layover flights from Detroit to Knoxville. Airlines include United Airlines at $388 with a layover in Chicago, and American Airlines at $395 with a layover in New York. Flight times are 8 hours 25 minutes and 10 hours 45 minutes, respectively.

What are the most convenient layover airports for my flight from Detroit to Knoxville?

For your flight from Detroit to Knoxville, convenient layover airports include Chicago O'Hare, Reagan Washington National, and New York LaGuardia.

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Return flights

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Flight Deals from Detroit to Knoxville from $243

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

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Top Deals on flights from Detroit to Knoxville

Frequently Asked Questions

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