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Business Class Flight Deals from Knoxville to Detroit from $315

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Bundle + Save

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Stops

  • Up to 1 stop
    $545

Airlines

  • American Airlines
    $545

Cabin Class

  • First
    $545

Departure Airports

  • McGhee Tyson Airport
    $545

Arrival Airports

  • Detroit Metropolitan Airport
    $545

Layover Airports

  • Charlotte Douglas International Airport
    $589
  • Chicago O Hare Airport
    $545
  • New York LaGuardia Airport
    $561
  • Philadelphia International Airport
    $589
  • Reagan Washington National Airport
    $545

Best Price. GUARANTEED.

Exclusively for Priceline Members
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We'll refund the difference if you find a lower price.

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On average save $240 per traveler
American Airlines Logo
American Airlines

08/15/25

TYS
21h 15m
ORD

08/16/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$545
American Airlines Logo
American Airlines

08/15/25

TYS
6h 51m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 51m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 31m
ORD

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 27m
DCA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
6h 1m
ORD

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
4h 28m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
6h 1m
ORD

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
4h 28m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 27m
DCA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
4h 28m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
7h 2m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 47m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 51m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
4h 28m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 47m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 37m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
4h 28m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 37m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 27m
DCA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 31m
ORD

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 27m
DCA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 47m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 31m
ORD

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 47m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
6h 51m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 37m
DCA

08/22/25

TYS
$561
American Airlines Logo
American Airlines

08/15/25

TYS
4h 59m
LGA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
6h 1m
ORD

08/22/25

TYS
$579
American Airlines Logo
American Airlines

08/15/25

TYS
4h 59m
LGA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$579
American Airlines Logo
American Airlines

08/15/25

TYS
4h 37m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$579
American Airlines Logo
American Airlines

08/15/25

TYS
4h 59m
LGA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 31m
ORD

08/22/25

TYS
$579
American Airlines Logo
American Airlines

08/15/25

TYS
4h 59m
LGA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$579
American Airlines Logo
American Airlines

08/15/25

TYS
4h 59m
LGA

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 37m
DCA

08/22/25

TYS
$579
American Airlines Logo
American Airlines

08/15/25

TYS
4h 28m
ORD

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 55m
PHL

08/22/25

TYS
$589
American Airlines Logo
American Airlines

08/15/25

TYS
3h 26m
CLT

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 31m
ORD

08/22/25

TYS
$589
American Airlines Logo
American Airlines

08/15/25

TYS
5h 31m
CLT

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$589
American Airlines Logo
American Airlines

08/15/25

TYS
3h 26m
CLT

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
6h 1m
ORD

08/22/25

TYS
$589
American Airlines Logo
American Airlines

08/15/25

TYS
3h 26m
CLT

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
5h 14m
LGA

08/22/25

TYS
$589
American Airlines Logo
American Airlines

08/15/25

TYS
3h 26m
CLT

08/15/25

DTW
American Airlines Logo
American Airlines

08/22/25

DTW
4h 6m
DCA

08/22/25

TYS
$589

Top Deals on flights Business Class from Knoxville to Detroit

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
6h 27m
DCA

Aug 15

DTW

as low as

$315

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
6h 47m
ORD

Aug 15

DTW

as low as

$315

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
4h 28m
ORD

Aug 15

DTW

as low as

$315

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
6h 51m
ORD

Aug 15

DTW

as low as

$315

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
5h 31m
CLT

Aug 15

DTW

as low as

$348

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
8h 1m
DFW

Aug 15

DTW

as low as

$348

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
3h 26m
CLT

Aug 15

DTW

as low as

$348

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
4h 59m
LGA

Aug 15

DTW

as low as

$360

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
6h 10m
DCA

Aug 15

DTW

as low as

$495

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
8h 52m
DFW

Aug 15

DTW

as low as

$548

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
8h 58m
LGA

Aug 15

DTW

as low as

$555

Knoxville, US (TYS) - Detroit, US (DTT)

American Airlines Logo
American Airlines

Aug 15

TYS
14h 57m
LGA

Aug 15

DTW

as low as

$565

Frequently Asked Questions

What is the time difference between destination and arrival?
The time difference between Knoxville and Detroit is typically one hour, with Detroit being one hour ahead.
Is there a direct flight from Knoxville to Detroit?
There is no direct flight from Knoxville to Detroit. The available flights are one stop with American Airlines at prices of $545 and $589.
Are there convenient layover flights from Knoxville to Detroit?
Yes, there is a convenient 1 stop flight from McGhee Tyson Airport to Detroit Metropolitan Airport with American Airlines priced at $545, featuring a layover at Chicago O Hare Airport and a flight time of 21 hours 15 minutes.
What are the most convenient layover airports for my flight?
For your flight from Knoxville to Detroit, convenient layover airports include Chicago O'Hare, Charlotte Douglas, Atlanta Hartsfield, Dallas/Fort Worth, and Washington Dulles, commonly served by airlines like American Airlines and Delta.
What is the cheapest and fastest flight from Knoxville to Detroit?
The cheapest flight is with American Airlines at $545, taking 21 hours 15 minutes. The fastest flight is also with American Airlines at $589, taking 3 hours 26 minutes.
What are all possible destination arrival airports?
The possible destination arrival airport is Detroit Metropolitan Airport. Layover airports include Chicago O'Hare Airport and Charlotte Douglas International Airport.