$244 Flight Deals from Santo Domingo to Buffalo

Top flight deals from leading airlines:

... and +100s more

Incredible Deals

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Stops

Up to 1 stop
$427
Up to 2 stops
$471

Airlines

American Airlines
$613
JetBlue
$427
United Airlines
$471

Cabin Class

Economy
$427

Departure Airports

Las Américas International Airport
$427

Arrival Airports

Buffalo Niagara International Airport
$427

Layover Airports

Charlotte Douglas International Airport
$613
Chicago O Hare Airport
$471
Fort Lauderdale Hollywood International Airport
$427
General Edward Lawrence Logan International Airport
$493
Miami International Airport
$613
New York John F Kennedy Airport
$446
Newark Liberty Airport
$471
Orlando International Airport
$467
Philadelphia International Airport
$613
Reagan Washington National Airport
$613
Washington Dulles Airport
$529

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

JetBlue

09/13/25

2:34pm

SDQ

7h 46m

FLL

09/13/25

10:20pm

BUF

JetBlue

09/20/25

5:30pm

BUF

19h 55m

FLL

09/21/25

1:25pm

SDQ

^$427

JetBlue

09/13/25

2:34pm

SDQ

7h 46m

FLL

09/13/25

10:20pm

BUF

JetBlue

09/20/25

3:55pm

BUF

9h 4m

JFK

09/21/25

12:59am

SDQ

^$446

JetBlue

09/13/25

8:10am

SDQ

6h 47m

JFK

09/13/25

2:57pm

BUF

JetBlue

09/20/25

5:30pm

BUF

19h 55m

FLL

09/21/25

1:25pm

SDQ

^$456

JetBlue

09/13/25

5:05am

SDQ

9h 52m

JFK

09/13/25

2:57pm

BUF

JetBlue

09/20/25

5:30pm

BUF

19h 55m

FLL

09/21/25

1:25pm

SDQ

^$456

JetBlue

09/13/25

8:10am

SDQ

10h 54m

JFK

09/13/25

7:04pm

BUF

JetBlue

09/20/25

5:30pm

BUF

19h 55m

FLL

09/21/25

1:25pm

SDQ

^$456

JetBlue

09/13/25

2:34pm

SDQ

7h 46m

FLL

09/13/25

10:20pm

BUF

JetBlue

09/20/25

7:59pm

BUF

15h 23m

JFK

09/21/25

11:22am

SDQ

^$464

JetBlue

09/13/25

7:22am

SDQ

13h 45m

MCO

09/13/25

9:07pm

BUF

JetBlue

09/20/25

5:30pm

BUF

19h 55m

FLL

09/21/25

1:25pm

SDQ

^$467

United Airlines

09/13/25

5:45am

SDQ

15h 31m

EWR

ORD

09/13/25

9:16pm

BUF

United Airlines

09/20/25

7:05am

BUF

18h 45m

ORD

EWR

09/21/25

1:50am

SDQ

^$471

United Airlines

09/13/25

5:45am

SDQ

11h 7m

EWR

ORD

09/13/25

4:52pm

BUF

United Airlines

09/20/25

7:05am

BUF

18h 45m

ORD

EWR

09/21/25

1:50am

SDQ

^$471

United Airlines

09/13/25

5:45am

SDQ

11h 7m

EWR

ORD

09/13/25

4:52pm

BUF

United Airlines

09/20/25

5:54pm

BUF

18h 1m

ORD

EWR

09/21/25

11:55am

SDQ

^$471

United Airlines

09/13/25

5:45am

SDQ

11h 7m

EWR

ORD

09/13/25

4:52pm

BUF

United Airlines

09/20/25

5:54pm

BUF

20h 16m

ORD

EWR

09/21/25

2:10pm

SDQ

^$471

United Airlines

09/13/25

3:20pm

SDQ

22h 2m

EWR

ORD

09/14/25

1:22pm

BUF

United Airlines

09/20/25

5:54pm

BUF

18h 1m

ORD

EWR

09/21/25

11:55am

SDQ

^$471

JetBlue

09/13/25

7:22am

SDQ

13h 45m

MCO

09/13/25

9:07pm

BUF

JetBlue

09/20/25

3:55pm

BUF

9h 4m

JFK

09/21/25

12:59am

SDQ

^$486

JetBlue

09/13/25

2:34pm

SDQ

7h 46m

FLL

09/13/25

10:20pm

BUF

JetBlue

09/20/25

7:00am

BUF

15h 4m

BOS

JFK

09/20/25

10:04pm

SDQ

^$493

JetBlue

09/13/25

2:34pm

SDQ

7h 46m

FLL

09/13/25

10:20pm

BUF

JetBlue

09/20/25

10:00am

BUF

14h 59m

BOS

JFK

09/21/25

12:59am

SDQ

^$493

JetBlue

09/13/25

2:34pm

SDQ

7h 46m

FLL

09/13/25

10:20pm

BUF

JetBlue

09/20/25

10:00am

BUF

12h 4m

BOS

JFK

09/20/25

10:04pm

SDQ

^$493

JetBlue

09/13/25

7:22am

SDQ

13h 45m

MCO

09/13/25

9:07pm

BUF

JetBlue

09/20/25

7:59pm

BUF

17h 25m

JFK

09/21/25

1:24pm

SDQ

^$504

JetBlue

09/13/25

7:22am

SDQ

13h 45m

MCO

09/13/25

9:07pm

BUF

JetBlue

09/20/25

7:59pm

BUF

15h 23m

JFK

09/21/25

11:22am

SDQ

^$504

JetBlue

09/13/25

7:22am

SDQ

13h 45m

MCO

09/13/25

9:07pm

BUF

JetBlue

09/20/25

6:00am

BUF

16h 4m

JFK

09/20/25

10:04pm

SDQ

^$504

United Airlines

09/13/25

5:45am

SDQ

11h 7m

EWR

ORD

09/13/25

4:52pm

BUF

United Airlines

09/20/25

8:00pm

BUF

15h 55m

IAD

EWR

09/21/25

11:55am

SDQ

^$529

United Airlines

09/13/25

5:45am

SDQ

15h 31m

EWR

ORD

09/13/25

9:16pm

BUF

United Airlines

09/20/25

8:00pm

BUF

18h 10m

IAD

EWR

09/21/25

2:10pm

SDQ

^$529

United Airlines

09/13/25

5:45am

SDQ

15h 31m

EWR

ORD

09/13/25

9:16pm

BUF

United Airlines

09/20/25

8:00pm

BUF

15h 55m

IAD

EWR

09/21/25

11:55am

SDQ

^$529

United Airlines

09/13/25

5:45am

SDQ

11h 7m

EWR

ORD

09/13/25

4:52pm

BUF

United Airlines

09/20/25

8:00pm

BUF

18h 10m

IAD

EWR

09/21/25

2:10pm

SDQ

^$529

United Airlines

09/13/25

5:45am

SDQ

11h 7m

EWR

ORD

09/13/25

4:52pm

BUF

United Airlines

09/20/25

6:00am

BUF

19h 50m

IAD

EWR

09/21/25

1:50am

SDQ

^$529

American Airlines

09/13/25

4:20pm

SDQ

19h 9m

MIA

DCA

09/14/25

11:29am

BUF

American Airlines

09/20/25

8:00am

BUF

12h 30m

PHL

MIA

09/20/25

8:30pm

SDQ

^$613

American Airlines

09/13/25

7:00am

SDQ

14h 53m

MIA

CLT

09/13/25

9:53pm

BUF

American Airlines

09/20/25

6:50pm

BUF

16h 25m

CLT

MIA

09/21/25

11:15am

SDQ

^$613

American Airlines

09/13/25

4:20pm

SDQ

19h 9m

MIA

DCA

09/14/25

11:29am

BUF

American Airlines

09/20/25

7:35am

BUF

12h 55m

ORD

MIA

09/20/25

8:30pm

SDQ

^$613

American Airlines

09/13/25

4:20pm

SDQ

17h 27m

MIA

PHL

09/14/25

9:47am

BUF

American Airlines

09/20/25

8:00am

BUF

12h 30m

PHL

MIA

09/20/25

8:30pm

SDQ

^$613

American Airlines

09/13/25

7:00am

SDQ

14h 53m

MIA

CLT

09/13/25

9:53pm

BUF

American Airlines

09/20/25

8:00am

BUF

12h 30m

PHL

MIA

09/20/25

8:30pm

SDQ

^$613

American Airlines

09/13/25

4:20pm

SDQ

19h 9m

MIA

DCA

09/14/25

11:29am

BUF

American Airlines

09/20/25

6:50pm

BUF

16h 25m

CLT

MIA

09/21/25

11:15am

SDQ

^$613

Top Deals on flights from Santo Domingo to Buffalo

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

United Airlines

Sep 13

5:45am

SDQ

16h 26m

EWR

Sep 13

10:11pm

BUF

as low as

^$244

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

United Airlines

Sep 13

5:45am

SDQ

15h 31m

EWR

ORD

Sep 13

9:16pm

BUF

as low as

^$249

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

JetBlue

Sep 13

5:05am

SDQ

9h 52m

JFK

Sep 13

2:57pm

BUF

as low as

^$249

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

JetBlue

Sep 13

5:05am

SDQ

8h 59m

JFK

BOS

Sep 13

2:04pm

BUF

as low as

^$319

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

American Airlines

Sep 13

7:00am

SDQ

14h 53m

MIA

CLT

Sep 13

9:53pm

BUF

as low as

^$321

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

Sep 14

2:50pm

SDQ

8h 47m

ATL

Sep 14

11:37pm

BUF

as low as

^$328

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

American Airlines

Sep 14

4:20pm

SDQ

19h 50m

MIA

CLT

Sep 15

12:10pm

BUF

as low as

^$335

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

JetBlue

Sep 14

5:19pm

SDQ

27h 41m

MCO

Sep 15

9:00pm

BUF

as low as

^$340

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

JetBlue

Sep 14

5:19pm

SDQ

28h 48m

MCO

JFK

Sep 15

10:07pm

BUF

as low as

^$379

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

United Airlines

Sep 14

5:45am

SDQ

16h 6m

EWR

Sep 14

9:51pm

BUF

as low as

^$458

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

United Airlines

Sep 14

1:10pm

SDQ

20h 43m

EWR

ORD

Sep 15

9:53am

BUF

as low as

^$468

Santo Domingo, DO (SDQ) - Buffalo, US (BUF)

Sep 13

6:17pm

SDQ

15h 29m

PTY

IAD

Sep 14

9:46am

BUF

as low as

^$474

Frequently Asked Questions

What are all possible destination arrival airports?

The possible destination arrival airport is Buffalo Niagara International Airport. Layover airports include Fort Lauderdale Hollywood International Airport, New York John F Kennedy Airport, Newark Liberty Airport, Chicago O Hare Airport, General Edward Lawrence Logan International Airport, and Miami International Airport.

What is the time difference between destination and arrival?

The time difference between Santo Domingo and Buffalo is generally one hour, with Buffalo being one hour behind Santo Domingo.

Is there a direct flight from Santo Domingo to Buffalo?

There is no direct flight from Santo Domingo to Buffalo. The available options include 1 stop flights with JetBlue priced at $427 and $456, as well as United Airlines at $471, all involving layovers.

Are there convenient layover flights from Santo Domingo to Buffalo?

Convenient layover flights from Santo Domingo to Buffalo include JetBlue at $427 (1 stop, layover in Fort Lauderdale) and United Airlines at $471 (1 stop, layover in Newark). For 2 stops, options are United Airlines at $471, JetBlue at $503, and American Airlines at $613.

What are the most convenient layover airports for the flight?

The most convenient layover airports for your flight are Fort Lauderdale Hollywood International Airport, New York John F Kennedy Airport, Newark Liberty Airport, Chicago O Hare Airport, and Miami International Airport.

What are the cheapest and fastest flight options from Santo Domingo to Buffalo?

The cheapest flight is with JetBlue for $427, taking 7 hours 46 minutes. The fastest flight, also with JetBlue, costs $456 and takes 6 hours 47 minutes.

Flights to Buffalo

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Flight Deals from Santo Domingo to Buffalo from $244

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Santo Domingo to Buffalo

Frequently Asked Questions

Flights to Buffalo