$230 Flight Deals from Buffalo to Santo Domingo

Top flight deals from leading airlines:

... and +100s more

Incredible Deals

Save up to 50% on select flights with Priceline

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

Up to 1 stop
$432
Up to 2 stops
$448

Airlines

American Airlines
$556
JetBlue
$432
United Airlines
$487

Cabin Class

Economy
$432

Departure Airports

Buffalo Niagara International Airport
$432

Arrival Airports

Las Américas International Airport
$432

Layover Airports

Charlotte Douglas International Airport
$556
Chicago O Hare Airport
$487
Fort Lauderdale Hollywood International Airport
$432
General Edward Lawrence Logan International Airport
$448
Miami International Airport
$556
New York John F Kennedy Airport
$432
Newark Liberty Airport
$487
Orlando International Airport
$441
Philadelphia International Airport
$556
Reagan Washington National Airport
$556
Washington Dulles Airport
$487

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
We'll refund the difference if you find a lower price.

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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

JetBlue

09/13/25

6:00am

BUF

18h 7m

JFK

09/14/25

12:07am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$432

JetBlue

09/13/25

6:00am

BUF

20h 5m

JFK

09/14/25

2:05am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$432

JetBlue

09/13/25

6:00am

BUF

10h 54m

JFK

09/13/25

4:54pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$433

JetBlue

09/13/25

6:00am

BUF

7h 24m

JFK

09/13/25

1:24pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$433

JetBlue

09/13/25

8:00am

BUF

8h 9m

MCO

09/13/25

4:09pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$441

JetBlue

09/13/25

6:00am

BUF

7h 24m

JFK

09/13/25

1:24pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

25h 53m

FLL

09/21/25

4:27pm

BUF

^$447

JetBlue

09/13/25

6:00am

BUF

10h 54m

JFK

09/13/25

4:54pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

25h 53m

FLL

09/21/25

4:27pm

BUF

^$447

JetBlue

09/13/25

10:00am

BUF

14h 7m

BOS

JFK

09/14/25

12:07am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$448

JetBlue

09/13/25

8:30am

BUF

17h 35m

FLL

JFK

09/14/25

2:05am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$448

JetBlue

09/13/25

8:30am

BUF

15h 37m

FLL

JFK

09/14/25

12:07am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$448

JetBlue

09/13/25

10:00am

BUF

16h 5m

BOS

JFK

09/14/25

2:05am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$448

JetBlue

09/13/25

8:00am

BUF

24h 34m

MCO

09/14/25

8:34am

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$452

JetBlue

09/13/25

8:00am

BUF

8h 9m

MCO

09/13/25

4:09pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

25h 53m

FLL

09/21/25

4:27pm

BUF

^$454

JetBlue

09/13/25

7:00am

BUF

9h 54m

BOS

JFK

09/13/25

4:54pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

7h 46m

FLL

09/20/25

10:20pm

BUF

^$458

JetBlue

09/13/25

8:00am

BUF

8h 9m

MCO

09/13/25

4:09pm

SDQ

JetBlue

09/20/25

5:35am

SDQ

9h 22m

JFK

09/20/25

2:57pm

BUF

^$465

JetBlue

09/13/25

8:00am

BUF

8h 9m

MCO

09/13/25

4:09pm

SDQ

JetBlue

09/20/25

8:10am

SDQ

6h 47m

JFK

09/20/25

2:57pm

BUF

^$465

JetBlue

09/13/25

7:00am

BUF

9h 54m

BOS

JFK

09/13/25

4:54pm

SDQ

JetBlue

09/20/25

2:34pm

SDQ

25h 53m

FLL

09/21/25

4:27pm

BUF

^$472

JetBlue

09/13/25

8:00am

BUF

24h 34m

MCO

09/14/25

8:34am

SDQ

JetBlue

09/20/25

8:10am

SDQ

6h 47m

JFK

09/20/25

2:57pm

BUF

^$476

United Airlines

09/13/25

5:54pm

BUF

18h 1m

ORD

EWR

09/14/25

11:55am

SDQ

United Airlines

09/20/25

5:45am

SDQ

15h 31m

EWR

ORD

09/20/25

9:16pm

BUF

^$487

United Airlines

09/13/25

7:05am

BUF

18h 45m

ORD

EWR

09/14/25

1:50am

SDQ

United Airlines

09/20/25

3:20pm

SDQ

25h 32m

EWR

ORD

09/21/25

4:52pm

BUF

^$487

United Airlines

09/13/25

10:30am

BUF

15h 20m

IAD

EWR

09/14/25

1:50am

SDQ

United Airlines

09/20/25

5:45am

SDQ

15h 31m

EWR

ORD

09/20/25

9:16pm

BUF

^$487

United Airlines

09/13/25

8:00pm

BUF

18h 10m

IAD

EWR

09/14/25

2:10pm

SDQ

United Airlines

09/20/25

5:45am

SDQ

15h 31m

EWR

ORD

09/20/25

9:16pm

BUF

^$487

United Airlines

09/13/25

8:00pm

BUF

18h 10m

IAD

EWR

09/14/25

2:10pm

SDQ

United Airlines

09/20/25

3:20pm

SDQ

25h 32m

EWR

ORD

09/21/25

4:52pm

BUF

^$487

United Airlines

09/13/25

8:00pm

BUF

15h 55m

IAD

EWR

09/14/25

11:55am

SDQ

United Airlines

09/20/25

5:45am

SDQ

15h 31m

EWR

ORD

09/20/25

9:16pm

BUF

^$487

American Airlines

09/13/25

5:33pm

BUF

17h 42m

ORD

MIA

09/14/25

11:15am

SDQ

American Airlines

09/20/25

4:20pm

SDQ

19h 9m

MIA

DCA

09/21/25

11:29am

BUF

^$556

American Airlines

09/13/25

5:33pm

BUF

17h 42m

ORD

MIA

09/14/25

11:15am

SDQ

American Airlines

09/20/25

2:35pm

SDQ

19h 12m

MIA

PHL

09/21/25

9:47am

BUF

^$556

American Airlines

09/13/25

6:50pm

BUF

16h 25m

CLT

MIA

09/14/25

11:15am

SDQ

American Airlines

09/20/25

2:35pm

SDQ

20h 54m

MIA

DCA

09/21/25

11:29am

BUF

^$556

American Airlines

09/13/25

6:50pm

BUF

16h 25m

CLT

MIA

09/14/25

11:15am

SDQ

American Airlines

09/20/25

4:20pm

SDQ

19h 9m

MIA

DCA

09/21/25

11:29am

BUF

^$556

American Airlines

09/13/25

6:50pm

BUF

18h 45m

CLT

MIA

09/14/25

1:35pm

SDQ

American Airlines

09/20/25

4:20pm

SDQ

17h 27m

MIA

PHL

09/21/25

9:47am

BUF

^$556

American Airlines

09/13/25

6:50pm

BUF

16h 25m

CLT

MIA

09/14/25

11:15am

SDQ

American Airlines

09/20/25

2:35pm

SDQ

19h 12m

MIA

PHL

09/21/25

9:47am

BUF

^$556

Top Deals on flights from Buffalo to Santo Domingo

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

United Airlines

Sep 13

5:54pm

BUF

18h 1m

ORD

EWR

Sep 14

11:55am

SDQ

as low as

^$230

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

JetBlue

Sep 13

8:00am

BUF

8h 9m

MCO

Sep 13

4:09pm

SDQ

as low as

^$237

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

JetBlue

Sep 13

10:00am

BUF

16h 5m

BOS

JFK

Sep 14

2:05am

SDQ

as low as

^$260

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

American Airlines

Sep 13

6:50pm

BUF

16h 25m

CLT

MIA

Sep 14

11:15am

SDQ

as low as

^$265

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

JetBlue

Sep 2

5:35am

BUF

6h 20m

JFK

Sep 2

11:55am

SDQ

as low as

^$269

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

United Airlines

Sep 2

8:00pm

BUF

15h 55m

IAD

EWR

Sep 3

11:55am

SDQ

as low as

^$279

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

Sep 2

6:50pm

BUF

18h 32m

DTW

ATL

Sep 3

1:22pm

SDQ

as low as

^$306

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

Sep 2

11:35am

BUF

6h 25m

JFK

Sep 2

6:00pm

SDQ

as low as

^$306

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

American Airlines

Sep 2

6:33pm

BUF

16h 42m

CLT

MIA

Sep 3

11:15am

SDQ

as low as

^$317

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

Aug 14

7:34pm

BUF

17h 48m

DTW

ATL

Aug 15

1:22pm

SDQ

as low as

^$331

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

JetBlue

Sep 2

5:35am

BUF

12h 15m

JFK

MCO

Sep 2

5:50pm

SDQ

as low as

^$335

Buffalo, US (BUF) - Santo Domingo, DO (SDQ)

United Airlines

Sep 2

6:30am

BUF

7h 40m

EWR

Sep 2

2:10pm

SDQ

as low as

^$339

Frequently Asked Questions

Are there convenient layover flights from Buffalo to Santo Domingo?

Yes, you can find convenient layover flights from Buffalo to Santo Domingo. JetBlue offers a 1-stop flight for $432, with a layover at New York John F Kennedy Airport. Additionally, 2-stop options are available with JetBlue for $448, United Airlines for $487, and American Airlines for $556.

What are the most convenient layover airports for the flight?

For your flight from Buffalo to Santo Domingo, convenient layover airports include New York John F Kennedy Airport, General Edward Lawrence Logan International Airport, Chicago O'Hare Airport, Newark Liberty Airport, and Charlotte Douglas International Airport.

What is the cheapest and fastest flight from Buffalo to Santo Domingo?

The cheapest flight is with JetBlue for $432, taking 20 hours 5 minutes. The fastest flight is also with JetBlue for $433, taking 7 hours 24 minutes.

What are all possible destination arrival airports?

The possible destination arrival airport is Las Américas International Airport in Santo Domingo.

What is the time difference between destination and arrival?

The flight from Buffalo to Santo Domingo typically has an approximate time difference of 1 hour, with Santo Domingo being ahead.

Is there a direct flight from Buffalo to Santo Domingo?

There is no direct flight from Buffalo to Santo Domingo.

Flights to Santo Domingo

Flights
Caribbean
Dominican Republic
Santo Domingo

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Flight Deals from Buffalo to Santo Domingo from $230

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Buffalo to Santo Domingo

Frequently Asked Questions

Flights to Santo Domingo