$351 Flight Deals from Panama City to Buffalo

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... and +100s more

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Stops

Up to 1 stop
$1325
Up to 2 stops
$623

Airlines

American Airlines
$737
COPA Airlines
$1325
United Airlines
$623

Cabin Class

Economy
$623

Departure Airports

Tocumen International Airport
$623

Arrival Airports

Buffalo Niagara International Airport
$623

Layover Airports

Charlotte Douglas International Airport
$737
Chicago O Hare Airport
$639
George Bush Intercontinental Houston Airport
$684
Miami International Airport
$737
Newark Liberty Airport
$623
Philadelphia International Airport
$737
Reagan Washington National Airport
$737
Washington Dulles Airport
$623

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Exclusively for Priceline Members
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

United Airlines

09/13/25

9:45am

PTY

23h 1m

EWR

IAD

09/14/25

9:46am

BUF

United Airlines

09/20/25

8:00pm

BUF

18h 50m

IAD

EWR

09/21/25

1:50pm

PTY

^$623

United Airlines

09/13/25

9:45am

PTY

27h 21m

EWR

IAD

09/14/25

2:06pm

BUF

United Airlines

09/20/25

8:00pm

BUF

18h 50m

IAD

EWR

09/21/25

1:50pm

PTY

^$637

United Airlines

09/13/25

9:45am

PTY

30h 7m

EWR

ORD

09/14/25

4:52pm

BUF

United Airlines

09/20/25

8:00pm

BUF

18h 50m

IAD

EWR

09/21/25

1:50pm

PTY

^$639

United Airlines

09/13/25

3:30pm

PTY

22h 54m

IAH

EWR

09/14/25

3:24pm

BUF

United Airlines

09/20/25

8:00pm

BUF

18h 50m

IAD

EWR

09/21/25

1:50pm

PTY

^$684

United Airlines

09/13/25

9:45am

PTY

23h 1m

EWR

IAD

09/14/25

9:46am

BUF

United Airlines

09/20/25

5:54pm

BUF

20h 56m

ORD

EWR

09/21/25

1:50pm

PTY

^$684

United Airlines

09/13/25

9:45am

PTY

27h 21m

EWR

IAD

09/14/25

2:06pm

BUF

United Airlines

09/20/25

5:54pm

BUF

20h 56m

ORD

EWR

09/21/25

1:50pm

PTY

^$698

American Airlines

09/13/25

3:31pm

PTY

18h 58m

MIA

DCA

09/14/25

11:29am

BUF

American Airlines

09/20/25

6:50pm

BUF

20h 41m

CLT

MIA

09/21/25

2:31pm

PTY

^$737

American Airlines

09/13/25

3:31pm

PTY

23h 30m

MIA

PHL

09/14/25

4:01pm

BUF

American Airlines

09/20/25

6:50pm

BUF

20h 41m

CLT

MIA

09/21/25

2:31pm

PTY

^$737

American Airlines

09/13/25

3:31pm

PTY

17h 16m

MIA

PHL

09/14/25

9:47am

BUF

American Airlines

09/20/25

5:33pm

BUF

21h 58m

ORD

MIA

09/21/25

2:31pm

PTY

^$737

American Airlines

09/13/25

3:31pm

PTY

18h 58m

MIA

DCA

09/14/25

11:29am

BUF

American Airlines

09/20/25

5:33pm

BUF

21h 58m

ORD

MIA

09/21/25

2:31pm

PTY

^$737

American Airlines

09/13/25

3:31pm

PTY

20h 32m

MIA

PHL

09/14/25

1:03pm

BUF

American Airlines

09/20/25

6:50pm

BUF

20h 41m

CLT

MIA

09/21/25

2:31pm

PTY

^$737

American Airlines

09/13/25

3:31pm

PTY

18h 29m

MIA

CLT

09/14/25

11:00am

BUF

American Airlines

09/20/25

5:33pm

BUF

21h 58m

ORD

MIA

09/21/25

2:31pm

PTY

^$737

United Airlines

09/13/25

3:30pm

PTY

22h 54m

IAH

EWR

09/14/25

3:24pm

BUF

United Airlines

09/20/25

5:54pm

BUF

20h 56m

ORD

EWR

09/21/25

1:50pm

PTY

^$745

American Airlines

09/13/25

3:31pm

PTY

21h 34m

MIA

DCA

09/14/25

2:05pm

BUF

American Airlines

09/20/25

6:50pm

BUF

20h 41m

CLT

MIA

09/21/25

2:31pm

PTY

^$756

COPA Airlines

09/13/25

9:13am

PTY

8h 48m

IAD

09/13/25

7:01pm

BUF

COPA Airlines

09/20/25

6:00am

BUF

15h 34m

IAD

09/20/25

8:34pm

PTY

^$1325

COPA Airlines

09/13/25

9:13am

PTY

8h 48m

IAD

09/13/25

7:01pm

BUF

COPA Airlines

09/20/25

6:00am

BUF

25h 13m

IAD

09/21/25

6:13am

PTY

^$1334

Top Deals on flights from Panama City to Buffalo

Panama City, PA (PTY) - Buffalo, US (BUF)

United Airlines

Sep 13

9:45am

PTY

23h 1m

EWR

IAD

Sep 14

9:46am

BUF

as low as

^$351

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines

Sep 13

3:31pm

PTY

20h 32m

MIA

PHL

Sep 14

1:03pm

BUF

as low as

^$356

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines

Sep 13

3:31pm

PTY

18h 29m

MIA

CLT

Sep 14

11:00am

BUF

as low as

^$356

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines

Sep 13

3:31pm

PTY

17h 16m

MIA

PHL

Sep 14

9:47am

BUF

as low as

^$362

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines

Sep 13

3:31pm

PTY

18h 58m

MIA

DCA

Sep 14

11:29am

BUF

as low as

^$362

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines

Sep 13

3:31pm

PTY

18h 35m

MIA

ORD

Sep 14

11:06am

BUF

as low as

^$362

Panama City, PA (PTY) - Buffalo, US (BUF)

United Airlines

Sep 13

9:45am

PTY

27h 21m

EWR

IAD

Sep 14

2:06pm

BUF

as low as

^$365

Panama City, PA (PTY) - Buffalo, US (BUF)

United Airlines

Sep 13

9:45am

PTY

30h 7m

EWR

ORD

Sep 14

4:52pm

BUF

as low as

^$367

Panama City, PA (PTY) - Buffalo, US (BUF)

United Airlines

Sep 13

9:45am

PTY

34h 31m

EWR

ORD

Sep 14

9:16pm

BUF

as low as

^$367

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines

Sep 13

3:31pm

PTY

21h 34m

MIA

DCA

Sep 14

2:05pm

BUF

as low as

^$381

Panama City, PA (PTY) - Buffalo, US (BUF)

United Airlines

Sep 13

3:30pm

PTY

22h 54m

IAH

EWR

Sep 14

3:24pm

BUF

as low as

^$407

Panama City, PA (PTY) - Buffalo, US (BUF)

United Airlines

Sep 13

9:45am

PTY

11h 26m

EWR

Sep 13

10:11pm

BUF

as low as

^$523

Frequently Asked Questions

What is the time difference between destination and arrival?

The time difference between Panama City and Buffalo is typically one hour, with Buffalo being one hour ahead during standard time.

Is there a direct flight from Panama City to Buffalo?

There is no direct flight from Panama City to Buffalo. The cheapest available flight is with United Airlines for $623 with 2 stops, and the fastest option is with COPA Airlines for $1325 with 1 stop.

Are there convenient layover flights from Panama City to Buffalo?

Yes, convenient layover flights include: United Airlines $775 (1 stop, Newark, 11h 26m), COPA Airlines $1325 (1 stop, Washington Dulles, 8h 48m), United Airlines $623 (2 stops, Newark/Washington Dulles, 23h 1m), American Airlines $737 (2 stops, Miami/Philadelphia, 23h 30m).

What are the most convenient layover airports for the flight?

For your flight from Panama City to Buffalo, convenient layover airports include Newark Liberty Airport, Washington Dulles Airport, Miami International Airport, and Philadelphia International Airport.

What are the cheapest and fastest flights from Panama City to Buffalo?

The cheapest flight is with United Airlines at $623, 2 stops, 23h 1m. The fastest option is with COPA Airlines at $1325, 1 stop, 8h 48m.

What are all possible destination arrival airports?

Possible destination arrival airports include Buffalo Niagara International Airport, Newark Liberty Airport, Washington Dulles Airport, Miami International Airport, and Philadelphia International Airport.

Flights to Buffalo

Top Destinations

Origins

Return flights

Cabin Class

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Flight Deals from Panama City to Buffalo from $351

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Panama City to Buffalo

Frequently Asked Questions

Flights to Buffalo