$265 Flight Deals from Buffalo to Panama City

Top flight deals from leading airlines:

... and +100s more

Incredible Deals

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Stops

Up to 1 stop
$1204
Up to 2 stops
$546

Airlines

American Airlines
$607
COPA Airlines
$1204
United Airlines
$546

Cabin Class

Economy
$546

Departure Airports

Buffalo Niagara International Airport
$546

Arrival Airports

Tocumen International Airport
$546

Layover Airports

Charlotte Douglas International Airport
$607
Chicago O Hare Airport
$585
George Bush Intercontinental Houston Airport
$546
Miami International Airport
$607
Newark Liberty Airport
$546
Philadelphia International Airport
$607
Reagan Washington National Airport
$607
Washington Dulles Airport
$546

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
We'll refund the difference if you find a lower price.

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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

United Airlines

09/13/25

8:00pm

BUF

18h 50m

IAD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

9:45am

PTY

23h 1m

EWR

IAD

09/21/25

9:46am

BUF

^$546

United Airlines

09/13/25

8:00pm

BUF

18h 50m

IAD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

3:30pm

PTY

22h 54m

IAH

EWR

09/21/25

3:24pm

BUF

^$546

United Airlines

09/13/25

5:54pm

BUF

20h 56m

ORD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

3:30pm

PTY

22h 54m

IAH

EWR

09/21/25

3:24pm

BUF

^$585

United Airlines

09/13/25

5:54pm

BUF

20h 56m

ORD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

9:45am

PTY

23h 1m

EWR

IAD

09/21/25

9:46am

BUF

^$585

United Airlines

09/13/25

8:00pm

BUF

18h 50m

IAD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

10:00am

PTY

22h 48m

IAH

EWR

09/21/25

9:48am

BUF

^$590

United Airlines

09/13/25

8:00pm

BUF

18h 50m

IAD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

9:45am

PTY

23h 8m

EWR

ORD

09/21/25

9:53am

BUF

^$590

United Airlines

09/13/25

7:05am

BUF

31h 45m

ORD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

9:45am

PTY

23h 1m

EWR

IAD

09/21/25

9:46am

BUF

^$602

United Airlines

09/13/25

7:05am

BUF

31h 45m

ORD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

3:30pm

PTY

22h 54m

IAH

EWR

09/21/25

3:24pm

BUF

^$602

United Airlines

09/13/25

8:00pm

BUF

18h 50m

IAD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

9:45am

PTY

30h 7m

EWR

ORD

09/21/25

4:52pm

BUF

^$606

United Airlines

09/13/25

8:00pm

BUF

18h 50m

IAD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

9:45am

PTY

34h 31m

EWR

ORD

09/21/25

9:16pm

BUF

^$606

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

24h 30m

MIA

DCA

09/21/25

5:01pm

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

23h 30m

MIA

PHL

09/21/25

4:01pm

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

18h 35m

MIA

ORD

09/21/25

11:06am

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

18h 29m

MIA

CLT

09/21/25

11:00am

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

20h 21m

MIA

CLT

09/21/25

12:52pm

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

17h 16m

MIA

PHL

09/21/25

9:47am

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

21h 34m

MIA

DCA

09/21/25

2:05pm

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

20h 32m

MIA

PHL

09/21/25

1:03pm

BUF

^$607

American Airlines

09/13/25

6:00am

BUF

9h 31m

DCA

MIA

09/13/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

18h 58m

MIA

DCA

09/21/25

11:29am

BUF

^$607

United Airlines

09/13/25

5:54pm

BUF

20h 56m

ORD

EWR

09/14/25

1:50pm

PTY

United Airlines

09/20/25

10:00am

PTY

22h 48m

IAH

EWR

09/21/25

9:48am

BUF

^$629

American Airlines

09/13/25

5:33pm

BUF

21h 58m

ORD

MIA

09/14/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

18h 29m

MIA

CLT

09/21/25

11:00am

BUF

^$651

American Airlines

09/13/25

6:50pm

BUF

20h 41m

CLT

MIA

09/14/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

18h 29m

MIA

CLT

09/21/25

11:00am

BUF

^$651

American Airlines

09/13/25

6:50pm

BUF

20h 41m

CLT

MIA

09/14/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

20h 32m

MIA

PHL

09/21/25

1:03pm

BUF

^$651

American Airlines

09/13/25

5:33pm

BUF

21h 58m

ORD

MIA

09/14/25

2:31pm

PTY

American Airlines

09/20/25

3:31pm

PTY

17h 16m

MIA

PHL

09/21/25

9:47am

BUF

^$651

COPA Airlines

09/13/25

6:00am

BUF

8h 31m

IAD

09/13/25

1:31pm

PTY

COPA Airlines

09/20/25

6:38pm

PTY

14h 8m

IAD

09/21/25

9:46am

BUF

^$1204

COPA Airlines

09/13/25

6:00am

BUF

8h 31m

IAD

09/13/25

1:31pm

PTY

COPA Airlines

09/20/25

10:29pm

PTY

10h 17m

IAD

09/21/25

9:46am

BUF

^$1204

COPA Airlines

09/13/25

8:00pm

BUF

11h 13m

IAD

09/14/25

6:13am

PTY

COPA Airlines

09/20/25

10:29pm

PTY

10h 17m

IAD

09/21/25

9:46am

BUF

^$1204

COPA Airlines

09/13/25

8:00pm

BUF

11h 13m

IAD

09/14/25

6:13am

PTY

COPA Airlines

09/20/25

6:38pm

PTY

14h 8m

IAD

09/21/25

9:46am

BUF

^$1204

COPA Airlines

09/13/25

10:30am

BUF

11h 4m

IAD

09/13/25

8:34pm

PTY

COPA Airlines

09/20/25

10:29pm

PTY

10h 17m

IAD

09/21/25

9:46am

BUF

^$1204

COPA Airlines

09/13/25

10:30am

BUF

11h 4m

IAD

09/13/25

8:34pm

PTY

COPA Airlines

09/20/25

6:38pm

PTY

14h 8m

IAD

09/21/25

9:46am

BUF

^$1204

Top Deals on flights from Buffalo to Panama City

Buffalo, US (BUF) - Panama City, PA (PTY)

United Airlines

Sep 13

8:00pm

BUF

18h 50m

IAD

EWR

Sep 14

1:50pm

PTY

as low as

^$265

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

6:00am

BUF

9h 31m

DCA

MIA

Sep 13

2:31pm

PTY

as low as

^$268

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

6:50pm

BUF

20h 41m

CLT

MIA

Sep 14

2:31pm

PTY

as low as

^$318

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

5:33pm

BUF

21h 58m

ORD

MIA

Sep 14

2:31pm

PTY

as low as

^$318

Buffalo, US (BUF) - Panama City, PA (PTY)

United Airlines

Sep 13

5:54pm

BUF

20h 56m

ORD

EWR

Sep 14

1:50pm

PTY

as low as

^$320

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

1:00pm

BUF

26h 31m

CLT

MIA

Sep 14

2:31pm

PTY

as low as

^$339

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

12:10pm

BUF

27h 21m

PHL

MIA

Sep 14

2:31pm

PTY

as low as

^$339

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

2:35pm

BUF

24h 56m

DCA

MIA

Sep 14

2:31pm

PTY

as low as

^$339

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

11:46am

BUF

27h 45m

ORD

MIA

Sep 14

2:31pm

PTY

as low as

^$340

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

8:00am

BUF

31h 31m

PHL

MIA

Sep 14

2:31pm

PTY

as low as

^$345

Buffalo, US (BUF) - Panama City, PA (PTY)

American Airlines

Sep 13

4:14pm

BUF

23h 17m

PHL

MIA

Sep 14

2:31pm

PTY

as low as

^$407

Buffalo, US (BUF) - Panama City, PA (PTY)

United Airlines

Sep 13

10:30am

BUF

28h 20m

IAD

EWR

Sep 14

1:50pm

PTY

as low as

^$418

Frequently Asked Questions

Are there convenient layover flights from Buffalo to Panama City?

Yes, there are convenient layover flights from Buffalo to Panama City. Options include: United Airlines for $546 (2 stops, 18h 50m) and American Airlines for $607 (2 stops, 9h 31m). The 1 stop flight with COPA Airlines is available for $1204 (1 stop, 8h 31m).

What are the most convenient layover airports for my flight?

For your flight from Buffalo to Panama City, convenient layover airports include Washington Dulles, Newark Liberty, and Reagan Washington National. These airports provide good connections with United Airlines and American Airlines.

What is the cheapest and fastest flight from Buffalo to Panama City?

The cheapest flight is with United Airlines for $546, 18 hours 50 minutes. The fastest is with COPA Airlines for $1204, 8 hours 31 minutes.

What are all possible destination arrival airports?

The destination arrival airport for your flights is Tocumen International Airport in Panama City.

What is the time difference between destination and arrival?

The time difference between Buffalo and Panama City is typically one hour, with Panama City being one hour ahead of Buffalo.

Is there a direct flight from Buffalo to Panama City?

There is no direct flight from Buffalo to Panama City. The cheapest flight with United Airlines costs $546 with 2 stops, and the fastest flight with COPA Airlines has 1 stop costing $1204.

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Flight Deals from Buffalo to Panama City from $265

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Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Buffalo to Panama City

Frequently Asked Questions

Flights to Panama City