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Business Class Flight Deals from Panama City to Buffalo from $542

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Bundle + Save

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Stops

  • Up to 1 stop
    $2561
  • Up to 2 stops
    $1154

Airlines

  • American Airlines
    $1154
  • COPA Airlines
    $2561

Cabin Class

  • Business
    $1154

Departure Airports

  • Tocumen International Airport
    $1154

Arrival Airports

  • Buffalo Niagara International Airport
    $1154

Layover Airports

  • Charlotte Douglas International Airport
    $1154
  • Chicago O Hare Airport
    $1154
  • Miami International Airport
    $1154
  • Philadelphia International Airport
    $1304
  • Reagan Washington National Airport
    $1154
  • Washington Dulles Airport
    $2561

Best Price. GUARANTEED.

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On average save $240 per traveler
American Airlines Logo
American Airlines

08/02/25

PTY
19h 23m
MIA
DCA

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
19h 52m
CLT
MIA

08/10/25

PTY
$1154
American Airlines Logo
American Airlines

08/02/25

PTY
18h 48m
MIA
CLT

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
19h 52m
CLT
MIA

08/10/25

PTY
$1154
American Airlines Logo
American Airlines

08/02/25

PTY
18h 48m
MIA
CLT

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
22h 32m
ORD
MIA

08/10/25

PTY
$1154
American Airlines Logo
American Airlines

08/02/25

PTY
19h 23m
MIA
DCA

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
22h 32m
ORD
MIA

08/10/25

PTY
$1154
American Airlines Logo
American Airlines

08/02/25

PTY
18h 48m
MIA
CLT

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 15m
CLT
MIA

08/09/25

PTY
$1237
American Airlines Logo
American Airlines

08/02/25

PTY
19h 23m
MIA
DCA

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 15m
CLT
MIA

08/09/25

PTY
$1237
American Airlines Logo
American Airlines

08/02/25

PTY
18h 48m
MIA
CLT

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 30m
DCA
MIA

08/09/25

PTY
$1237
American Airlines Logo
American Airlines

08/02/25

PTY
19h 23m
MIA
DCA

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 30m
DCA
MIA

08/09/25

PTY
$1237
American Airlines Logo
American Airlines

08/02/25

PTY
19h 8m
MIA
PHL

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
19h 52m
CLT
MIA

08/10/25

PTY
$1304
American Airlines Logo
American Airlines

08/02/25

PTY
19h 8m
MIA
PHL

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 30m
DCA
MIA

08/09/25

PTY
$1387
American Airlines Logo
American Airlines

08/02/25

PTY
19h 8m
MIA
PHL

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 15m
CLT
MIA

08/09/25

PTY
$1387
American Airlines Logo
American Airlines

08/02/25

PTY
20h 3m
MIA
CLT

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 30m
DCA
MIA

08/09/25

PTY
$1387
American Airlines Logo
American Airlines

08/02/25

PTY
20h 23m
MIA
PHL

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 30m
DCA
MIA

08/09/25

PTY
$1387
American Airlines Logo
American Airlines

08/02/25

PTY
19h 46m
MIA
ORD

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 15m
CLT
MIA

08/09/25

PTY
$1387
American Airlines Logo
American Airlines

08/02/25

PTY
19h 46m
MIA
ORD

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 30m
DCA
MIA

08/09/25

PTY
$1387
American Airlines Logo
American Airlines

08/02/25

PTY
20h 23m
MIA
PHL

08/03/25

BUF
American Airlines Logo
American Airlines

08/09/25

BUF
9h 15m
CLT
MIA

08/09/25

PTY
$1387
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
8h 43m
IAD

08/02/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
11h 28m
IAD

08/10/25

PTY
$2561
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
14h 8m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
18h 11m
IAD

08/10/25

PTY
$2561
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
14h 8m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
11h 28m
IAD

08/10/25

PTY
$2561
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
10h 17m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
18h 11m
IAD

08/10/25

PTY
$2561
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
8h 43m
IAD

08/02/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
18h 11m
IAD

08/10/25

PTY
$2561
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
10h 17m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
11h 28m
IAD

08/10/25

PTY
$2561
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
8h 43m
IAD

08/02/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
20h 43m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
10h 17m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
20h 43m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
10h 17m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
27h 26m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
10h 17m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
25h 49m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
19h 27m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
18h 11m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
8h 43m
IAD

08/02/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
27h 26m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
14h 8m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
25h 13m
IAD

08/10/25

PTY
$2575
COPA Airlines Logo
COPA Airlines

08/02/25

PTY
14h 8m
IAD

08/03/25

BUF
COPA Airlines Logo
COPA Airlines

08/09/25

BUF
25h 49m
IAD

08/10/25

PTY
$2575

Top Deals on flights Business Class from Panama City to Buffalo

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
20h 47m
MIA
CLT

Aug 3

BUF

as low as

$542

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
18h 48m
MIA
CLT

Aug 3

BUF

as low as

$542

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
19h 23m
MIA
DCA

Aug 3

BUF

as low as

$542

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
21h 1m
MIA
ORD

Aug 3

BUF

as low as

$692

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
19h 8m
MIA
PHL

Aug 3

BUF

as low as

$692

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
20h 23m
MIA
PHL

Aug 3

BUF

as low as

$692

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
19h 46m
MIA
ORD

Aug 3

BUF

as low as

$692

Panama City, PA (PTY) - Buffalo, US (BUF)

American Airlines Logo
American Airlines

Aug 2

PTY
20h 38m
MIA
DCA

Aug 3

BUF

as low as

$692

Panama City, PA (PTY) - Buffalo, US (BUF)

COPA Airlines Logo
COPA Airlines

Aug 2

PTY
8h 43m
IAD

Aug 2

BUF

as low as

$1313

Panama City, PA (PTY) - Buffalo, US (BUF)

COPA Airlines Logo
COPA Airlines

Aug 2

PTY
14h 8m
IAD

Aug 3

BUF

as low as

$1313

Panama City, PA (PTY) - Buffalo, US (BUF)

COPA Airlines Logo
COPA Airlines

Aug 2

PTY
10h 17m
IAD

Aug 3

BUF

as low as

$1313

Frequently Asked Questions

What is the cheapest and fastest flight from Panama City to Buffalo?
The cheapest flight is with American Airlines at $1154, taking 19 hours 23 minutes with 2 stops. The fastest flight is with COPA Airlines at $2561, taking 8 hours 43 minutes with 1 stop.
What are all possible destination arrival airports?
The possible destination arrival airport is Buffalo Niagara International Airport, with layovers at Miami International Airport, Reagan Washington National Airport, and Washington Dulles Airport.
What is the time difference between destination and arrival?
Flying from Panama City to Buffalo involves a time difference of one hour, with Buffalo being one hour ahead of Panama City.
Is there a direct flight from Panama City to Buffalo?
There is no direct flight from Panama City to Buffalo. The cheapest option has 2 stops with American Airlines at $1154, and the fastest option has 1 stop with COPA Airlines at $2561.
Are there convenient layover flights from Panama City to Buffalo?
Yes, convenient layover flights from Panama City to Buffalo include a 1 stop flight with COPA Airlines for $ 2561, and a 2 stops flight with American Airlines for $ 1154.
What are the most convenient layover airports for the flight?
For your trip from Panama City to Buffalo, convenient layover airports are Miami International Airport, Reagan Washington National Airport, and Washington Dulles Airport, offered by American Airlines and COPA Airlines.
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