$298 Flight Deals from Houston to Panama City

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Stops

Nonstop
from $913
Up to 1 stop
$783
Up to 2 stops
$778

Airlines

Aeromexico
$783
American Airlines
$826
AVIANCA
$778
COPA Airlines
$1036
Delta Air Lines
$927
United Airlines
$826

Cabin Class

Economy
$778

Departure Airports

George Bush Intercontinental Houston Airport
$778
William P Hobby Airport
$1351

Arrival Airports

Tocumen International Airport
$778

Layover Airports

Dallas Fort Worth International Airport
$1351
El Dorado International Airport
$778
Hartsfield Jackson Atlanta International Airport
$927
Juan Santamaria International Airport
$778
Licenciado Benito Juarez International Airport
$783
Miami International Airport
$826
Monseñor Óscar Arnulfo Romero International Airport
$778

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

AVIANCA

11/21/25

1:00pm

IAH

23h 50m

SAL

SJO

11/22/25

12:50pm

PTY

AVIANCA

11/28/25

2:55am

PTY

12h 15m

BOG

SAL

11/28/25

3:10pm

IAH

^$778

Aeromexico

11/07/25

10:55am

IAH

26h 37m

MEX

11/08/25

1:32pm

PTY

Aeromexico

11/26/25

2:36pm

PTY

18h 51m

MEX

11/27/25

9:27am

IAH

^$783

Aeromexico

11/07/25

7:20pm

IAH

18h 12m

MEX

11/08/25

1:32pm

PTY

Aeromexico

11/26/25

2:36pm

PTY

18h 51m

MEX

11/27/25

9:27am

IAH

^$806

American Airlines

11/07/25

5:46am

IAH

7h 50m

MIA

11/07/25

1:36pm

PTY

American Airlines

11/26/25

2:43pm

PTY

9h 47m

MIA

11/27/25

12:30am

IAH

^$826

United Airlines

12/05/25

4:57pm

IAH

19h 31m

SJO

12/06/25

12:28pm

PTY

United Airlines

12/09/25

8:25pm

PTY

13h 39m

SAL

12/10/25

10:04am

IAH

^$826

Aeromexico

11/01/25

7:50pm

IAH

17h 42m

MEX

11/02/25

1:32pm

PTY

Aeromexico

11/15/25

2:36pm

PTY

18h 51m

MEX

11/16/25

9:27am

IAH

^$837

Aeromexico

11/21/25

10:55am

IAH

26h 37m

MEX

11/22/25

1:32pm

PTY

Aeromexico

11/29/25

2:36pm

PTY

18h 51m

MEX

11/30/25

9:27am

IAH

^$837

American Airlines

12/04/25

5:49am

IAH

7h 36m

MIA

12/04/25

1:25pm

PTY

American Airlines

12/14/25

4:15pm

PTY

6h 45m

MIA

12/14/25

11:00pm

IAH

^$850

Aeromexico

11/01/25

11:55am

IAH

25h 37m

MEX

11/02/25

1:32pm

PTY

Aeromexico

11/15/25

2:36pm

PTY

18h 51m

MEX

11/16/25

9:27am

IAH

^$863

American Airlines

11/01/25

7:25am

IAH

6h 38m

MIA

11/01/25

2:03pm

PTY

American Airlines

11/15/25

2:43pm

PTY

9h 47m

MIA

11/16/25

12:30am

IAH

^$864

AVIANCA

12/05/25

4:35pm

IAH

17h 45m

SAL

12/06/25

10:20am

PTY

AVIANCA

12/09/25

8:25pm

PTY

14h 40m

SAL

12/10/25

11:05am

IAH

^$880

AVIANCA

11/21/25

4:35pm

IAH

17h 45m

SAL

11/22/25

10:20am

PTY

AVIANCA

11/28/25

3:45pm

PTY

19h 20m

SJO

SAL

11/29/25

11:05am

IAH

^$907

United Airlines

12/05/25

11:56am

IAH

5h 11m

Direct

12/05/25

5:07pm

PTY

United Airlines

12/09/25

8:25pm

PTY

13h 39m

SAL

12/10/25

10:04am

IAH

^$912

AVIANCA

11/23/25

4:35pm

IAH

17h 45m

SAL

11/24/25

10:20am

PTY

AVIANCA

11/30/25

8:25pm

PTY

14h 40m

SAL

12/01/25

11:05am

IAH

^$912

United Airlines

11/21/25

9:34am

IAH

5h 11m

Direct

11/21/25

2:45pm

PTY

United Airlines

11/29/25

4:41pm

PTY

3h 29m

Direct

11/29/25

8:10pm

IAH

^$913

American Airlines

11/24/25

6:08pm

IAH

19h 28m

MIA

11/25/25

1:36pm

PTY

American Airlines

12/01/25

2:43pm

PTY

9h 47m

MIA

12/02/25

12:30am

IAH

^$914

Delta Air Lines

12/05/25

7:15am

IAH

12h 46m

ATL

12/05/25

8:01pm

PTY

Delta Air Lines

12/09/25

3:17pm

PTY

17h 27m

ATL

12/10/25

8:44am

IAH

^$927

Aeromexico

11/23/25

10:55am

IAH

26h 37m

MEX

11/24/25

1:32pm

PTY

Aeromexico

11/30/25

2:36pm

PTY

18h 51m

MEX

12/01/25

9:27am

IAH

^$959

Aeromexico

11/26/25

10:55am

IAH

26h 37m

MEX

11/27/25

1:32pm

PTY

Aeromexico

11/30/25

2:36pm

PTY

18h 51m

MEX

12/01/25

9:27am

IAH

^$959

AVIANCA

11/21/25

4:35pm

IAH

17h 45m

SAL

11/22/25

10:20am

PTY

AVIANCA

11/28/25

8:25pm

PTY

14h 40m

SAL

11/29/25

11:05am

IAH

^$988

American Airlines

11/28/25

5:56am

IAH

7h 24m

MIA

11/28/25

1:20pm

PTY

American Airlines

12/01/25

2:43pm

PTY

9h 47m

MIA

12/02/25

12:30am

IAH

^$988

United Airlines

12/05/25

2:27pm

IAH

5h 11m

Direct

12/05/25

7:38pm

PTY

United Airlines

12/09/25

4:41pm

PTY

3h 29m

Direct

12/09/25

8:10pm

IAH

^$1013

COPA Airlines

12/05/25

11:56am

IAH

5h 11m

Direct

12/05/25

5:07pm

PTY

COPA Airlines

12/09/25

4:41pm

PTY

3h 29m

Direct

12/09/25

8:10pm

IAH

^$1036

United Airlines

11/21/25

12:21pm

IAH

26h 29m

SAL

11/22/25

2:50pm

PTY

United Airlines

11/29/25

8:55am

PTY

3h 19m

Direct

11/29/25

12:14pm

IAH

^$1058

United Airlines

11/21/25

12:21pm

IAH

26h 29m

SAL

11/22/25

2:50pm

PTY

United Airlines

11/29/25

8:25pm

PTY

13h 39m

SAL

11/30/25

10:04am

IAH

^$1102

United Airlines

11/21/25

12:21pm

IAH

26h 29m

SAL

11/22/25

2:50pm

PTY

United Airlines

11/29/25

2:55am

PTY

32h 10m

BOG

SAL

11/30/25

11:05am

IAH

^$1349

American Airlines

11/26/25

8:20pm

HOU

17h

DFW

MIA

11/27/25

1:20pm

PTY

American Airlines

11/29/25

2:43pm

PTY

19h 43m

MIA

11/30/25

10:26am

HOU

^$1351

COPA Airlines

11/21/25

9:34am

IAH

5h 11m

Direct

11/21/25

2:45pm

PTY

COPA Airlines

11/28/25

4:41pm

PTY

3h 29m

Direct

11/28/25

8:10pm

IAH

^$1436

COPA Airlines

12/05/25

2:27pm

IAH

5h 11m

Direct

12/05/25

7:38pm

PTY

COPA Airlines

12/09/25

8:25pm

PTY

14h 40m

SAL

12/10/25

11:05am

IAH

^$1451

AVIANCA

12/05/25

4:35pm

IAH

17h 45m

SAL

12/06/25

10:20am

PTY

AVIANCA

12/09/25

11:35am

PTY

3h 19m

Direct

12/09/25

2:54pm

IAH

^$1452

Top Deals on flights from Houston to Panama City

Houston, US (HOU) - Panama City, PA (PTY)

United Airlines

Sep 1

6:09pm

IAH

16h 16m

SAL

Sep 2

10:25am

PTY

as low as

^$298

Houston, US (HOU) - Panama City, PA (PTY)

United Airlines

Sep 30

4:52pm

IAH

13h 41m

SJO

Oct 1

6:33am

PTY

as low as

^$324

Houston, US (HOU) - Panama City, PA (PTY)

Aeromexico

Oct 1

12:50pm

IAH

24h 52m

MEX

Oct 2

1:42pm

PTY

as low as

^$409

Houston, US (HOU) - Panama City, PA (PTY)

AVIANCA

Jan 20

4:35pm

IAH

17h 45m

SAL

Jan 21

10:20am

PTY

as low as

^$444

Houston, US (HOU) - Panama City, PA (PTY)

AVIANCA

Sep 19

5:40pm

IAH

22h 50m

SAL

BOG

Sep 20

4:30pm

PTY

as low as

^$448

Houston, US (HOU) - Panama City, PA (PTY)

United Airlines

Jan 20

11:56am

IAH

5h 11m

Direct

Jan 20

5:07pm

PTY

as low as

^$634

Houston, US (HOU) - Panama City, PA (PTY)

American Airlines

Jan 6

4:17pm

IAH

20h 53m

CLT

MIA

Jan 7

1:10pm

PTY

as low as

^$638

Houston, US (HOU) - Panama City, PA (PTY)

American Airlines

Jan 20

4:30pm

IAH

20h 40m

DFW

MIA

Jan 21

1:10pm

PTY

as low as

^$638

Houston, US (HOU) - Panama City, PA (PTY)

Delta Air Lines

Jan 20

6:00am

IAH

8h 2m

ATL

Jan 20

2:02pm

PTY

as low as

^$698

Houston, US (HOU) - Panama City, PA (PTY)

Delta Air Lines

Dec 18

6:00am

HOU

7h 52m

ATL

Dec 18

1:52pm

PTY

as low as

^$718

Houston, US (HOU) - Panama City, PA (PTY)

COPA Airlines

Dec 10

11:56am

IAH

5h 11m

Direct

Dec 10

5:07pm

PTY

as low as

^$938

Houston, US (HOU) - Panama City, PA (PTY)

Jan 23

6:20pm

IAH

15h

YYC

Jan 24

9:20am

PTY

as low as

^$1220

Frequently Asked Questions

What are the most convenient layover airports for my flight to Panama City?

Consider Monseñor Óscar Arnulfo Romero International Airport, Juan Santamaria International Airport, Dallas Fort Worth International Airport, Miami International Airport, and Hartsfield Jackson Atlanta International Airport for convenient layovers.

What is the cheapest and fastest flight from Houston to Panama City?

The cheapest flight is with AVIANCA at $778, taking 23 hours 50 minutes. The fastest flight is with United Airlines at $912, taking 5 hours 11 minutes.

What are all possible destination arrival airports?

Possible destination arrival airports include Tocumen International Airport, Monseñor Óscar Arnulfo Romero International Airport, Juan Santamaria International Airport, Dallas Fort Worth International Airport, Miami International Airport, and Hartsfield Jackson Atlanta International Airport.

What is the time difference between destination and arrival?

The time difference between Houston and Panama City is typically 1 hour, with Panama being one hour ahead of Houston.

Is there a direct flight from Houston to Panama City?

Yes, there are direct flights available from George Bush Intercontinental Houston Airport to Tocumen International Airport. Airlines offering this service include United Airlines at a price of $912 and COPA Airlines at a price of $1036.

Are there convenient layover flights from Houston to Panama City?

Yes, there are convenient layover flights available. Airlines offering one-stop options include Aeromexico for $783, United Airlines for $826, American Airlines for $826, AVIANCA for $880, and Delta Air Lines for $927. The two-stop flight with AVIANCA is available for $778.

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Flight Deals from Houston to Panama City from $298

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Arrival Airports

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Top Deals on flights from Houston to Panama City

Frequently Asked Questions

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