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Flight Deals from Detroit to Santiago from $163

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Bundle + Save

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Stops

  • Up to 1 stop
    $351
  • Up to 2 stops
    $666

Airlines

  • JetBlue
    $666
  • Spirit Airlines
    $351
  • United Airlines
    $847

Cabin Class

  • Economy
    $351

Departure Airports

  • Detroit Metropolitan Airport
    $351

Arrival Airports

  • Cibao International Airport
    $351

Layover Airports

  • Chicago O Hare Airport
    $851
  • Fort Lauderdale Hollywood International Airport
    $351
  • General Edward Lawrence Logan International Airport
    $666
  • New York John F Kennedy Airport
    $666
  • Newark Liberty Airport
    $847
  • Orlando International Airport
    $666

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE
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On average save $240 per traveler
Spirit Airlines Logo
Spirit Airlines

07/22/25

DTW
16h 24m
FLL

07/23/25

STI
Spirit Airlines Logo
Spirit Airlines

07/29/25

STI
13h 33m
FLL

07/30/25

DTW
$351
Spirit Airlines Logo
Spirit Airlines

07/22/25

DTW
27h 20m
FLL

07/23/25

STI
Spirit Airlines Logo
Spirit Airlines

07/29/25

STI
13h 33m
FLL

07/30/25

DTW
$359
Spirit Airlines Logo
Spirit Airlines

07/22/25

DTW
16h 24m
FLL

07/23/25

STI
Spirit Airlines Logo
Spirit Airlines

07/29/25

STI
23h 28m
FLL

07/30/25

DTW
$359
Spirit Airlines Logo
Spirit Airlines

07/22/25

DTW
27h 20m
FLL

07/23/25

STI
Spirit Airlines Logo
Spirit Airlines

07/29/25

STI
23h 28m
FLL

07/30/25

DTW
$368
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
32h 20m
JFK
BOS

07/30/25

DTW
$666
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
29h 36m
JFK
BOS

07/30/25

DTW
$666
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
10h 46m
JFK

07/29/25

DTW
$669
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
25h 21m
JFK

07/30/25

DTW
$679
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
21h 42m
JFK

07/29/25

DTW
$679
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
18h 58m
JFK

07/29/25

DTW
$679
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
28h 49m
JFK

07/30/25

DTW
$679
JetBlue Logo
JetBlue

07/22/25

DTW
16h 9m
JFK
MCO

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
13h 51m
JFK
BOS

07/29/25

DTW
$682
JetBlue Logo
JetBlue

07/22/25

DTW
19h 35m
BOS
JFK

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
29h 36m
JFK
BOS

07/30/25

DTW
$682
JetBlue Logo
JetBlue

07/22/25

DTW
21h 5m
JFK

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
10h 46m
JFK

07/29/25

DTW
$685
JetBlue Logo
JetBlue

07/22/25

DTW
21h 5m
JFK

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
18h 58m
JFK

07/29/25

DTW
$695
JetBlue Logo
JetBlue

07/22/25

DTW
21h 5m
JFK

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
21h 42m
JFK

07/29/25

DTW
$695
JetBlue Logo
JetBlue

07/22/25

DTW
21h 5m
JFK

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
25h 21m
JFK

07/30/25

DTW
$695
JetBlue Logo
JetBlue

07/22/25

DTW
7h 43m
JFK

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
18h 58m
JFK

07/29/25

DTW
$730
JetBlue Logo
JetBlue

07/22/25

DTW
7h 43m
JFK

07/22/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
21h 42m
JFK

07/29/25

DTW
$730
JetBlue Logo
JetBlue

07/22/25

DTW
14h 16m
BOS

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
10h 46m
JFK

07/29/25

DTW
$766
JetBlue Logo
JetBlue

07/22/25

DTW
14h 13m
BOS

07/23/25

STI
JetBlue Logo
JetBlue

07/29/25

STI
10h 46m
JFK

07/29/25

DTW
$780
United Airlines Logo
United Airlines

07/22/25

DTW
8h 12m
EWR

07/22/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
17h 10m
EWR

07/29/25

DTW
$847
United Airlines Logo
United Airlines

07/22/25

DTW
16h 1m
EWR

07/23/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
17h 10m
EWR

07/29/25

DTW
$847
United Airlines Logo
United Airlines

07/22/25

DTW
8h 12m
EWR

07/22/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
16h 25m
EWR

07/30/25

DTW
$847
United Airlines Logo
United Airlines

07/22/25

DTW
16h 1m
EWR

07/23/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
16h 25m
EWR

07/30/25

DTW
$847
United Airlines Logo
United Airlines

07/22/25

DTW
9h 12m
ORD
EWR

07/22/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
16h 25m
EWR

07/30/25

DTW
$851
United Airlines Logo
United Airlines

07/22/25

DTW
9h 12m
ORD
EWR

07/22/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
17h 10m
EWR

07/29/25

DTW
$851
United Airlines Logo
United Airlines

07/22/25

DTW
16h 1m
EWR

07/23/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
9h 3m
EWR

07/29/25

DTW
$881
United Airlines Logo
United Airlines

07/22/25

DTW
8h 12m
EWR

07/22/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
9h 3m
EWR

07/29/25

DTW
$881
United Airlines Logo
United Airlines

07/22/25

DTW
9h 12m
ORD
EWR

07/22/25

STI
United Airlines Logo
United Airlines

07/29/25

STI
9h 3m
EWR

07/29/25

DTW
$885

Top Deals on flights from Detroit to Santiago

Detroit, US (DTT) - Santiago, DO (STI)

Spirit Airlines Logo
Spirit Airlines

Jul 23

DTW
16h 24m
FLL

Jul 24

STI

as low as

$163

Detroit, US (DTT) - Santiago, DO (STI)

 Logo

Oct 23

DTW
6h 3m
MIA

Oct 23

STI

as low as

$253

Detroit, US (DTT) - Santiago, DO (STI)

 Logo

Oct 23

DTW
19h 34m
LGA
MIA

Oct 24

STI

as low as

$259

Detroit, US (DTT) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Oct 23

DTW
8h 12m
EWR

Oct 23

STI

as low as

$264

Detroit, US (DTT) - Santiago, DO (STI)

Spirit Airlines Logo
Spirit Airlines

Oct 23

DTW
5h 44m
FLL

Oct 23

STI

as low as

$265

Detroit, US (DTT) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Jul 23

DTW
21h 5m
JFK

Jul 24

STI

as low as

$324

Detroit, US (DTT) - Santiago, DO (STI)

JetBlue Logo
JetBlue

Jul 23

DTW
16h 9m
JFK
MCO

Jul 23

STI

as low as

$334

Detroit, US (DTT) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Oct 23

DTW
19h 46m
ORD
EWR

Oct 24

STI

as low as

$360

Detroit, US (DTT) - Santiago, DO (STI)

Spirit Airlines Logo
Spirit Airlines

Jun 25

DTW
14h 9m
FLL

Jun 26

STI

as low as

$418

Detroit, US (DTT) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Jul 23

DTW
18h 46m
EWR

Jul 24

STI

as low as

$446

Detroit, US (DTT) - Santiago, DO (STI)

 Logo

Aug 1

DTW
9h 43m
CLT
MIA

Aug 1

STI

as low as

$450

Detroit, US (DTT) - Santiago, DO (STI)

United Airlines Logo
United Airlines

Aug 1

DTW
9h 12m
ORD
EWR

Aug 1

STI

as low as

$465

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