$608 Business Class Flight Deals from Detroit to Santiago

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... and +100s more

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Stops

Up to 1 stop
$1384
Up to 2 stops
$1388

Airlines

American Airlines
$1384

Cabin Class

First
$1384
Business
$1472

Departure Airports

Detroit Metropolitan Airport
$1384

Arrival Airports

Cibao International Airport
$1384

Layover Airports

Charlotte Douglas International Airport
$1472
Chicago O Hare Airport
$1472
Miami International Airport
$1384
New York LaGuardia Airport
$1472
Reagan Washington National Airport
$1388

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

American Airlines

07/22/25

6:15am

DTW

15h 4m

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1384

American Airlines

07/22/25

6:15am

DTW

15h 4m

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1388

American Airlines

07/22/25

6:02am

DTW

15h 17m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

19h 39m

MIA

DCA

07/30/25

9:09am

DTW

^$1388

American Airlines

07/22/25

6:15am

DTW

15h 4m

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

19h 39m

MIA

DCA

07/30/25

9:09am

DTW

^$1388

American Airlines

07/22/25

9:39am

DTW

11h 40m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

19h 39m

MIA

DCA

07/30/25

9:09am

DTW

^$1388

American Airlines

07/22/25

6:02am

DTW

15h 17m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1388

American Airlines

07/22/25

9:39am

DTW

11h 40m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1388

American Airlines

07/22/25

6:02am

DTW

15h 17m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1388

American Airlines

07/22/25

9:39am

DTW

11h 40m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1388

American Airlines

07/22/25

6:15am

DTW

6h 14m

MIA

07/22/25

12:29pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1468

American Airlines

07/22/25

5:00am

DTW

16h 19m

ORD

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1472

American Airlines

07/22/25

7:15am

DTW

14h 4m

CLT

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1472

American Airlines

07/22/25

6:00am

DTW

15h 19m

LGA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1472

American Airlines

07/22/25

6:00am

DTW

15h 19m

LGA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1472

American Airlines

07/22/25

6:46am

DTW

14h 33m

ORD

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1472

American Airlines

07/22/25

6:46am

DTW

14h 33m

ORD

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1472

American Airlines

07/22/25

7:15am

DTW

14h 4m

CLT

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 45m

MIA

07/29/25

11:15pm

DTW

^$1472

American Airlines

07/22/25

5:00am

DTW

16h 19m

ORD

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

10h 27m

MIA

DCA

07/29/25

11:57pm

DTW

^$1472

American Airlines

07/22/25

6:15am

DTW

15h 4m

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

7:04am

STI

16h 11m

MIA

07/29/25

11:15pm

DTW

^$1491

American Airlines

07/22/25

9:39am

DTW

11h 40m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 5m

MIA

CLT

07/29/25

10:35pm

DTW

^$1495

American Airlines

07/22/25

6:02am

DTW

15h 17m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 5m

MIA

CLT

07/29/25

10:35pm

DTW

^$1495

American Airlines

07/22/25

6:15am

DTW

15h 4m

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

9h 5m

MIA

CLT

07/29/25

10:35pm

DTW

^$1495

American Airlines

07/22/25

6:02am

DTW

15h 17m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

11h 14m

MIA

CLT

07/30/25

12:44am

DTW

^$1495

American Airlines

07/22/25

9:39am

DTW

11h 40m

DCA

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

11h 14m

MIA

CLT

07/30/25

12:44am

DTW

^$1495

American Airlines

07/22/25

6:15am

DTW

15h 4m

MIA

07/22/25

9:19pm

STI

American Airlines

07/29/25

1:30pm

STI

11h 14m

MIA

CLT

07/30/25

12:44am

DTW

^$1495

Top Deals on flights Business Class from Detroit to Santiago

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

7:31pm

DTW

25h 48m

CLT

MIA

Jul 25

9:19pm

STI

as low as

^$608

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

3:03pm

DTW

30h 16m

CLT

MIA

Jul 25

9:19pm

STI

as low as

^$666

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

6:15am

DTW

6h 14m

MIA

Jul 24

12:29pm

STI

as low as

^$684

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

5:20pm

DTW

27h 59m

DCA

MIA

Jul 25

9:19pm

STI

as low as

^$690

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

5:38pm

DTW

27h 41m

LGA

MIA

Jul 25

9:19pm

STI

as low as

^$791

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

9:39am

DTW

11h 40m

DCA

MIA

Jul 24

9:19pm

STI

as low as

^$892

Detroit, US (DTT) - Santiago, DO (STI)

American Airlines

Jul 24

11:02am

DTW

34h 17m

LGA

MIA

Jul 25

9:19pm

STI

as low as

^$955

Frequently Asked Questions

What are the most convenient layover airports for the flight?

For your flight from Detroit to Santiago, consider layover airports such as Miami International Airport and Reagan Washington National Airport for convenience with American Airlines.

What is the cheapest and fastest flight from Detroit to Santiago?

The cheapest flight is with American Airlines at $1384, taking 15 hours 4 minutes. The fastest flight, also with American Airlines, costs $1468 and has a duration of 6 hours 14 minutes.

What are all possible destination arrival airports?

The possible destination arrival airport is Cibao International Airport, with layovers at Miami International Airport and Reagan Washington National Airport for various flight options.

What is the time difference between destination and arrival?

The time difference between Detroit and Santiago is typically one hour, with Santiago being one hour ahead of Detroit.

Is there a direct flight from Detroit to Santiago?

There is no direct flight from Detroit to Santiago. The available flights include 1 stop with American Airlines at prices of $1384 and $1468, and 2 stops also with American Airlines at $1388.

Are there convenient layover flights from Detroit to Santiago?

Yes, convenient layover flights include a 1 stop flight with American Airlines for $1384, with a layover in Miami and a flight time of 15 hours 4 minutes. Additionally, there is a 2 stops option for $1388 with American Airlines, with layovers in Reagan Washington and Miami, taking 15 hours 17 minutes.