$260 Flight Deals from Chicago to Panama City

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... and +100s more

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Stops

Nonstop
from $498
Up to 1 stop
$552
Up to 2 stops
$584

Airlines

American Airlines
$552
AVIANCA
$580
COPA Airlines
$498
United Airlines
$602

Cabin Class

Economy
$498

Departure Airports

Chicago O Hare Airport
$498

Arrival Airports

Tocumen International Airport
$498

Layover Airports

El Dorado International Airport
$580
George Bush Intercontinental Houston Airport
$602
Miami International Airport
$552
Monseñor Óscar Arnulfo Romero International Airport
$766
New York LaGuardia Airport
$584
Newark Liberty Airport
$602
Reagan Washington National Airport
$584
Washington Dulles Airport
$766

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

COPA Airlines

11/07/25

2:07pm

ORD

6h 28m

Direct

11/07/25

8:35pm

PTY

COPA Airlines

11/15/25

7:20pm

PTY

4h 45m

Direct

11/16/25

12:05am

ORD

^$498

COPA Airlines

11/03/25

6:56am

ORD

6h 26m

Direct

11/03/25

1:22pm

PTY

COPA Airlines

11/17/25

7:50am

PTY

4h 56m

Direct

11/17/25

12:46pm

ORD

^$498

COPA Airlines

11/23/25

2:07pm

ORD

6h 28m

Direct

11/23/25

8:35pm

PTY

COPA Airlines

11/26/25

7:50am

PTY

4h 56m

Direct

11/26/25

12:46pm

ORD

^$498

COPA Airlines

11/13/25

6:56am

ORD

6h 26m

Direct

11/13/25

1:22pm

PTY

COPA Airlines

11/17/25

7:50am

PTY

4h 56m

Direct

11/17/25

12:46pm

ORD

^$498

COPA Airlines

10/26/25

3:07pm

ORD

5h 28m

Direct

10/26/25

8:35pm

PTY

COPA Airlines

11/16/25

7:50am

PTY

4h 56m

Direct

11/16/25

12:46pm

ORD

^$513

American Airlines

11/05/25

7:07pm

ORD

18h 29m

MIA

11/06/25

1:36pm

PTY

American Airlines

11/25/25

2:43pm

PTY

8h 25m

MIA

11/25/25

11:08pm

ORD

^$552

American Airlines

11/18/25

7:07pm

ORD

18h 29m

MIA

11/19/25

1:36pm

PTY

American Airlines

11/23/25

2:43pm

PTY

8h 25m

MIA

11/23/25

11:08pm

ORD

^$557

American Airlines

11/05/25

7:07pm

ORD

18h 29m

MIA

11/06/25

1:36pm

PTY

American Airlines

11/25/25

2:43pm

PTY

9h 38m

MIA

11/26/25

12:21am

ORD

^$574

American Airlines

11/18/25

7:07pm

ORD

18h 29m

MIA

11/19/25

1:36pm

PTY

American Airlines

11/23/25

2:43pm

PTY

9h 38m

MIA

11/24/25

12:21am

ORD

^$579

AVIANCA

11/29/25

10:20pm

ORD

18h 35m

BOG

11/30/25

4:55pm

PTY

AVIANCA

12/03/25

11:25am

PTY

24h 50m

BOG

12/04/25

12:15pm

ORD

^$580

AVIANCA

10/26/25

11:20pm

ORD

25h 20m

BOG

10/28/25

12:40am

PTY

AVIANCA

11/16/25

5:55pm

PTY

26h 25m

BOG

11/17/25

8:20pm

ORD

^$580

AVIANCA

11/03/25

10:20pm

ORD

18h 35m

BOG

11/04/25

4:55pm

PTY

AVIANCA

11/17/25

2:55pm

PTY

29h 25m

BOG

11/18/25

8:20pm

ORD

^$580

American Airlines

11/18/25

8:57pm

ORD

16h 39m

DCA

MIA

11/19/25

1:36pm

PTY

American Airlines

11/23/25

2:43pm

PTY

16h 33m

MIA

DCA

11/24/25

7:16am

ORD

^$584

American Airlines

11/18/25

7:07pm

ORD

18h 29m

MIA

11/19/25

1:36pm

PTY

American Airlines

11/23/25

2:43pm

PTY

16h 58m

MIA

LGA

11/24/25

7:41am

ORD

^$584

United Airlines

11/22/25

7:55pm

ORD

18h 50m

IAH

11/23/25

2:45pm

PTY

United Airlines

11/30/25

4:41pm

PTY

9h 46m

IAH

12/01/25

2:27am

ORD

^$602

United Airlines

10/26/25

7:55pm

ORD

17h 50m

IAH

10/27/25

1:45pm

PTY

United Airlines

11/16/25

8:55am

PTY

15h 20m

IAH

11/17/25

12:15am

ORD

^$602

United Airlines

11/03/25

6:25pm

ORD

19h 30m

EWR

11/04/25

1:55pm

PTY

United Airlines

11/17/25

8:55am

PTY

11h 1m

IAH

11/17/25

7:56pm

ORD

^$602

United Airlines

11/07/25

9:08pm

ORD

16h 47m

EWR

11/08/25

1:55pm

PTY

United Airlines

11/15/25

8:55am

PTY

14h 20m

IAH

11/15/25

11:15pm

ORD

^$602

United Airlines

10/29/25

7:10am

ORD

11h 28m

IAH

10/29/25

6:38pm

PTY

United Airlines

12/08/25

8:55am

PTY

12h 21m

IAH

12/08/25

9:16pm

ORD

^$602

United Airlines

11/26/25

9:08pm

ORD

17h 37m

IAH

11/27/25

2:45pm

PTY

United Airlines

11/30/25

4:41pm

PTY

9h 46m

IAH

12/01/25

2:27am

ORD

^$602

United Airlines

11/13/25

6:00am

ORD

8h 45m

IAH

11/13/25

2:45pm

PTY

United Airlines

11/17/25

8:55am

PTY

12h 22m

IAH

11/17/25

9:17pm

ORD

^$602

American Airlines

10/14/25

8:35pm

ORD

17h 28m

DCA

MIA

10/15/25

2:03pm

PTY

American Airlines

12/13/25

4:15pm

PTY

7h 41m

MIA

12/13/25

11:56pm

ORD

^$623

AVIANCA

09/09/25

2:35pm

ORD

9h 35m

BOG

09/10/25

12:10am

PTY

AVIANCA

12/02/25

9:55pm

PTY

14h 20m

BOG

12/03/25

12:15pm

ORD

^$639

AVIANCA

11/26/25

10:20pm

ORD

18h 35m

BOG

11/27/25

4:55pm

PTY

AVIANCA

11/30/25

2:55pm

PTY

21h 20m

BOG

12/01/25

12:15pm

ORD

^$659

American Airlines

11/13/25

4:01pm

ORD

21h 35m

DCA

MIA

11/14/25

1:36pm

PTY

American Airlines

11/17/25

2:43pm

PTY

9h 38m

MIA

11/18/25

12:21am

ORD

^$683

American Airlines

11/13/25

2:50pm

ORD

22h 46m

LGA

MIA

11/14/25

1:36pm

PTY

American Airlines

11/17/25

2:43pm

PTY

17h 59m

MIA

LGA

11/18/25

8:42am

ORD

^$683

AVIANCA

11/03/25

10:20pm

ORD

15h 40m

BOG

11/04/25

2:00pm

PTY

AVIANCA

11/17/25

3:40pm

PTY

18h 6m

SAL

IAD

11/18/25

9:46am

ORD

^$766

AVIANCA

11/26/25

10:20pm

ORD

15h 40m

BOG

11/27/25

2:00pm

PTY

AVIANCA

11/30/25

8:25pm

PTY

27h 18m

SAL

IAD

12/01/25

11:43pm

ORD

^$796

AVIANCA

10/29/25

11:20pm

ORD

9h 30m

BOG

10/30/25

8:50am

PTY

AVIANCA

12/08/25

3:40pm

PTY

17h 56m

SAL

IAD

12/09/25

9:36am

ORD

^$825

American Airlines

11/30/25

5:00am

ORD

8h 36m

MIA

11/30/25

1:36pm

PTY

American Airlines

12/07/25

4:15pm

PTY

15h 5m

MIA

DCA

12/08/25

7:20am

ORD

^$846

Top Deals on flights from Chicago to Panama City

Chicago, US (CHI) - Panama City, PA (PTY)

AVIANCA

Oct 8

2:35pm

ORD

30h 35m

BOG

Oct 9

9:10pm

PTY

as low as

^$260

Chicago, US (CHI) - Panama City, PA (PTY)

AVIANCA

Aug 7

5:25pm

ORD

17h

SAL

Aug 8

10:25am

PTY

as low as

^$330

Chicago, US (CHI) - Panama City, PA (PTY)

COPA Airlines

Oct 8

3:50pm

ORD

13h 35m

SAN

Oct 9

5:25am

PTY

as low as

^$339

Chicago, US (CHI) - Panama City, PA (PTY)

AVIANCA

Aug 27

10:55am

ORD

22h

MIA

BOG

Aug 28

8:55am

PTY

as low as

^$387

Chicago, US (CHI) - Panama City, PA (PTY)

AVIANCA

Oct 23

8:50am

ORD

25h 35m

IAD

SAL

Oct 24

10:25am

PTY

as low as

^$402

Chicago, US (CHI) - Panama City, PA (PTY)

AVIANCA

Jan 9

2:35pm

ORD

22h

SJO

Jan 10

12:35pm

PTY

as low as

^$559

Chicago, US (CHI) - Panama City, PA (PTY)

United Airlines

Aug 16

7:41am

ORD

12h 34m

SJO

Aug 16

8:15pm

PTY

as low as

^$586

Chicago, US (CHI) - Panama City, PA (PTY)

United Airlines

Nov 8

7:55pm

ORD

18h 50m

IAH

Nov 9

2:45pm

PTY

as low as

^$608

Chicago, US (CHI) - Panama City, PA (PTY)

United Airlines

Aug 24

7:35pm

ORD

18h 15m

EWR

Aug 25

1:50pm

PTY

as low as

^$688

Chicago, US (CHI) - Panama City, PA (PTY)

American Airlines

Oct 18

7:00am

ORD

7h 3m

MIA

Oct 18

2:03pm

PTY

as low as

^$797

Chicago, US (CHI) - Panama City, PA (PTY)

Nov 8

5:20am

ORD

8h 36m

ATL

Nov 8

1:56pm

PTY

as low as

^$818

Chicago, US (CHI) - Panama City, PA (PTY)

American Airlines

Aug 27

8:34pm

ORD

17h 56m

CLT

MIA

Aug 28

2:30pm

PTY

as low as

^$843

Frequently Asked Questions

What are all possible destination arrival airports?

The possible destination arrival airport is Tocumen International Airport in Panama City.

What is the time difference between destination and arrival?

The time difference between Chicago and Panama City is typically one hour, with Panama being one hour ahead of Chicago.

Is there a direct flight from Chicago to Panama City?

Yes, there are direct flights from Chicago O Hare Airport to Tocumen International Airport. COPA Airlines offers the cheapest flight at $498 with a flight time of 6 hours 26 minutes and also a faster option at $622 with a flight time of 5 hours 20 minutes.

Are there convenient layover flights from Chicago to Panama City?

Yes, there are convenient layover flights. Notable options include American Airlines at $584 (2 stops, 16h 39m), AVIANCA at $858 (2 stops, 15h 20m), and United Airlines at $1440 (2 stops, 17h 25m). Additionally, 1 stop flights are available from American Airlines at $552, AVIANCA at $580, and United Airlines at $602.

What are the most convenient layover airports for the flight?

Consider Reagan Washington National Airport, Miami International Airport, Washington Dulles Airport, El Dorado International Airport, and George Bush Intercontinental Houston Airport for convenient layovers on your flight from Chicago to Panama City.

What are the cheapest and fastest flights from Chicago to Panama City?

The cheapest flight is with COPA Airlines for $498, taking 6 hours 26 minutes. The fastest option is also with COPA Airlines for $622, taking 5 hours 20 minutes.

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Flight Deals from Chicago to Panama City from $260

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Departure Airports

Arrival Airports

Layover Airports

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Top Deals on flights from Chicago to Panama City

Frequently Asked Questions

Flights to Panama City