$388 Flight Deals from Panama City to Chicago

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... and +100s more

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Stops

Nonstop
from $529
Up to 1 stop
$661
Up to 2 stops
$1090

Airlines

American Airlines
$680
AVIANCA
$738
COPA Airlines
$529
United Airlines
$661

Cabin Class

Economy
$529

Departure Airports

Tocumen International Airport
$529

Arrival Airports

Chicago O Hare Airport
$529

Layover Airports

El Dorado International Airport
$738
George Bush Intercontinental Houston Airport
$661
Miami International Airport
$680
Monseñor Óscar Arnulfo Romero International Airport
$1090
Newark Liberty Airport
$706
Washington Dulles Airport
$1090

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

COPA Airlines

09/06/25

6:45pm

PTY

5h 36m

Direct

09/07/25

12:21am

ORD

COPA Airlines

09/13/25

8:02am

ORD

5h 20m

Direct

09/13/25

1:22pm

PTY

^$529

COPA Airlines

09/06/25

7:55am

PTY

5h 46m

Direct

09/06/25

1:41pm

ORD

COPA Airlines

09/13/25

8:02am

ORD

5h 20m

Direct

09/13/25

1:22pm

PTY

^$545

United Airlines

09/06/25

10:00am

PTY

9h 58m

IAH

09/06/25

7:58pm

ORD

United Airlines

09/13/25

6:00am

ORD

12h 37m

IAH

09/13/25

6:37pm

PTY

^$661

United Airlines

09/06/25

3:30pm

PTY

18h 43m

IAH

09/07/25

10:13am

ORD

United Airlines

09/13/25

7:00am

ORD

11h 37m

IAH

09/13/25

6:37pm

PTY

^$661

United Airlines

09/06/25

10:00am

PTY

11h 40m

IAH

09/06/25

9:40pm

ORD

United Airlines

09/13/25

6:00am

ORD

8h 14m

IAH

09/13/25

2:14pm

PTY

^$661

United Airlines

09/06/25

10:00am

PTY

9h 58m

IAH

09/06/25

7:58pm

ORD

United Airlines

09/13/25

8:45am

ORD

9h 52m

IAH

09/13/25

6:37pm

PTY

^$661

United Airlines

09/06/25

10:00am

PTY

11h 40m

IAH

09/06/25

9:40pm

ORD

United Airlines

09/13/25

9:05pm

ORD

17h 9m

IAH

09/14/25

2:14pm

PTY

^$661

United Airlines

09/06/25

3:30pm

PTY

18h 43m

IAH

09/07/25

10:13am

ORD

United Airlines

09/13/25

8:45am

ORD

9h 52m

IAH

09/13/25

6:37pm

PTY

^$661

American Airlines

09/06/25

3:31pm

PTY

8h 18m

MIA

09/06/25

11:49pm

ORD

American Airlines

09/13/25

7:05am

ORD

7h 26m

MIA

09/13/25

2:31pm

PTY

^$680

American Airlines

09/06/25

3:31pm

PTY

17h 9m

MIA

09/07/25

8:40am

ORD

American Airlines

09/13/25

7:05am

ORD

7h 26m

MIA

09/13/25

2:31pm

PTY

^$680

American Airlines

09/06/25

3:31pm

PTY

17h 9m

MIA

09/07/25

8:40am

ORD

American Airlines

09/13/25

6:09am

ORD

8h 22m

MIA

09/13/25

2:31pm

PTY

^$680

American Airlines

09/06/25

3:31pm

PTY

17h 9m

MIA

09/07/25

8:40am

ORD

American Airlines

09/13/25

5:00am

ORD

9h 31m

MIA

09/13/25

2:31pm

PTY

^$680

American Airlines

09/06/25

3:31pm

PTY

8h 18m

MIA

09/06/25

11:49pm

ORD

American Airlines

09/13/25

6:09am

ORD

8h 22m

MIA

09/13/25

2:31pm

PTY

^$680

American Airlines

09/06/25

3:31pm

PTY

8h 18m

MIA

09/06/25

11:49pm

ORD

American Airlines

09/13/25

5:00am

ORD

9h 31m

MIA

09/13/25

2:31pm

PTY

^$680

United Airlines

09/06/25

9:45am

PTY

10h 26m

EWR

09/06/25

8:11pm

ORD

United Airlines

09/13/25

6:00am

ORD

12h 37m

IAH

09/13/25

6:37pm

PTY

^$706

United Airlines

09/06/25

9:45am

PTY

10h 26m

EWR

09/06/25

8:11pm

ORD

United Airlines

09/13/25

8:45am

ORD

9h 52m

IAH

09/13/25

6:37pm

PTY

^$706

United Airlines

09/06/25

9:45am

PTY

10h 26m

EWR

09/06/25

8:11pm

ORD

United Airlines

09/13/25

10:35am

ORD

8h 2m

IAH

09/13/25

6:37pm

PTY

^$706

United Airlines

09/06/25

9:45am

PTY

10h 26m

EWR

09/06/25

8:11pm

ORD

United Airlines

09/13/25

9:05pm

ORD

17h 9m

IAH

09/14/25

2:14pm

PTY

^$706

United Airlines

09/06/25

9:45am

PTY

10h 26m

EWR

09/06/25

8:11pm

ORD

United Airlines

09/13/25

6:00am

ORD

8h 14m

IAH

09/13/25

2:14pm

PTY

^$706

United Airlines

09/06/25

9:45am

PTY

10h 26m

EWR

09/06/25

8:11pm

ORD

United Airlines

09/13/25

7:00am

ORD

11h 37m

IAH

09/13/25

6:37pm

PTY

^$706

AVIANCA

09/06/25

10:05pm

PTY

15h 10m

BOG

09/07/25

1:15pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

19h 35m

BOG

09/14/25

10:10am

PTY

^$738

AVIANCA

09/06/25

10:05pm

PTY

15h 10m

BOG

09/07/25

1:15pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

25h 55m

BOG

09/14/25

4:30pm

PTY

^$738

AVIANCA

09/06/25

3:25am

PTY

9h 50m

BOG

09/06/25

1:15pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

19h 35m

BOG

09/14/25

10:10am

PTY

^$738

AVIANCA

09/06/25

10:05pm

PTY

15h 10m

BOG

09/07/25

1:15pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

9h 35m

BOG

09/14/25

12:10am

PTY

^$738

AVIANCA

09/06/25

3:25am

PTY

9h 50m

BOG

09/06/25

1:15pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

9h 35m

BOG

09/14/25

12:10am

PTY

^$738

AVIANCA

09/06/25

3:25am

PTY

9h 50m

BOG

09/06/25

1:15pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

25h 55m

BOG

09/14/25

4:30pm

PTY

^$738

AVIANCA

09/06/25

3:40pm

PTY

26h 45m

SAL

IAD

09/07/25

6:25pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

9h 35m

BOG

09/14/25

12:10am

PTY

^$1090

AVIANCA

09/06/25

8:10pm

PTY

22h 15m

SAL

IAD

09/07/25

6:25pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

9h 35m

BOG

09/14/25

12:10am

PTY

^$1090

AVIANCA

09/06/25

8:10pm

PTY

22h 15m

SAL

IAD

09/07/25

6:25pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

25h 55m

BOG

09/14/25

4:30pm

PTY

^$1090

AVIANCA

09/06/25

8:10pm

PTY

22h 15m

SAL

IAD

09/07/25

6:25pm

ORD

AVIANCA

09/13/25

2:35pm

ORD

19h 35m

BOG

09/14/25

10:10am

PTY

^$1090

Top Deals on flights from Panama City to Chicago

Panama City, PA (PTY) - Chicago, US (CHI)

AVIANCA

Nov 19

2:55am

PTY

17h 25m

BOG

Nov 19

8:20pm

ORD

as low as

^$388

Panama City, PA (PTY) - Chicago, US (CHI)

AVIANCA

Dec 24

3:40pm

PTY

23h 25m

SAL

Dec 25

3:05pm

ORD

as low as

^$406

Panama City, PA (PTY) - Chicago, US (CHI)

AVIANCA

Dec 8

3:19am

PTY

13h 23m

BOG

DFW

Dec 8

4:42pm

ORD

as low as

^$530

Panama City, PA (PTY) - Chicago, US (CHI)

AVIANCA

Sep 9

5:25pm

PTY

25h 21m

BOG

MIA

Sep 10

6:46pm

ORD

as low as

^$530

Panama City, PA (PTY) - Chicago, US (CHI)

AVIANCA

Sep 20

3:25am

PTY

39h

BOG

IAD

Sep 21

6:25pm

ORD

as low as

^$533

Panama City, PA (PTY) - Chicago, US (CHI)

AVIANCA

Aug 10

1:30pm

PTY

29h 20m

SJO

MIA

Aug 11

6:50pm

ORD

as low as

^$779

Panama City, PA (PTY) - Chicago, US (CHI)

United Airlines

Aug 17

7:55am

PTY

15h 17m

IAH

Aug 17

11:12pm

ORD

as low as

^$790

Panama City, PA (PTY) - Chicago, US (CHI)

COPA Airlines

Oct 27

3:23pm

PTY

29h 57m

BOG

Oct 28

9:20pm

ORD

as low as

^$795

Panama City, PA (PTY) - Chicago, US (CHI)

United Airlines

Aug 28

10:55pm

PTY

9h 43m

EWR

Aug 29

8:38am

ORD

as low as

^$799

Panama City, PA (PTY) - Chicago, US (CHI)

Aug 17

2:05pm

PTY

9h 51m

ATL

Aug 17

11:56pm

ORD

as low as

^$889

Panama City, PA (PTY) - Chicago, US (CHI)

American Airlines

Aug 14

3:30pm

PTY

8h 27m

MIA

Aug 14

11:57pm

ORD

as low as

^$889

Panama City, PA (PTY) - Chicago, US (CHI)

American Airlines

Aug 10

3:30pm

PTY

22h 33m

MIA

LGA

Aug 11

2:03pm

ORD

as low as

^$899

Frequently Asked Questions

What is the time difference between destination and arrival?

Traveling from Panama City to Chicago involves a time difference of two hours, with Chicago being ahead of Panama City.

Is there a direct flight from origin to destination?

Yes, there is a direct flight from Panama City to Chicago offered by COPA Airlines at a price of $529. The flight has no layovers and a duration of 5 hours 36 minutes.

Are there convenient layover flights from Panama City to Chicago?

Yes, there are convenient one-stop flights from Panama City to Chicago with United Airlines at $661, American Airlines at $680, and AVIANCA at $738. There are also two-stop flights with AVIANCA at $1090. The non-stop option is the cheapest at $529 with COPA Airlines.

What are the most convenient layover airports for the flight?

Consider layovers at George Bush Intercontinental, Miami International, Monseñor Óscar Arnulfo Romero, Washington Dulles, or El Dorado International airports for your flight from Panama City to Chicago.

What is the cheapest and fastest flight from Panama City to Chicago?

The cheapest and fastest flight is the non-stop flight from Tocumen International Airport to Chicago O Hare Airport with COPA Airlines at price $529, flight time of 5 hours 36 minutes.

What are all possible destination arrival airports?

The possible destination arrival airport for your flight is Chicago O'Hare Airport.

Flights to Chicago

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Return flights

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Flight Deals from Panama City to Chicago from $388

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Panama City to Chicago

Frequently Asked Questions

Flights to Chicago