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Flight Deals from Knoxville to Tampa from $149

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Bundle + Save

Top flight deals from leading airlines:

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Stops

  • Up to 1 stop
    $348

Airlines

  • American Airlines
    $348
  • Frontier Airlines
    $476
  • United Airlines
    $378

Cabin Class

  • Economy
    $348

Departure Airports

  • McGhee Tyson Airport
    $348

Arrival Airports

  • Tampa International Airport
    $348

Layover Airports

  • Charlotte Douglas International Airport
    $348
  • Chicago O Hare Airport
    $446
  • Denver International Airport
    $476
  • George Bush Intercontinental Houston Airport
    $551
  • Miami International Airport
    $348
  • Washington Dulles Airport
    $378

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE
Book a flight & hotel together for extra savings.
On average save $240 per traveler

EXPRESS DEAL

BUDGET FRIENDLY

You’re guaranteed to get one of these airlines:

DeltaDelta
AlaskaAlaska
UnitedUnited
AmericanAmerican
TYS TPA
Aug 13 ‧ Economy
$130

One Way

BUDGET FRIENDLY

You’re guaranteed to get one of these airlines:

DeltaDelta
AlaskaAlaska
UnitedUnited
AmericanAmerican
TYS TPA
Aug 14 ‧ Economy
$184

One Way

American Airlines Logo
American Airlines

09/07/25

TYS
4h 13m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 7m
CLT

09/15/25

TYS
$348
American Airlines Logo
American Airlines

09/07/25

TYS
4h 13m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
3h 45m
CLT

09/14/25

TYS
$348
American Airlines Logo
American Airlines

09/07/25

TYS
4h 13m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 51m
MIA

09/14/25

TYS
$348
American Airlines Logo
American Airlines

09/07/25

TYS
4h 13m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 32m
CLT

09/14/25

TYS
$378
American Airlines Logo
American Airlines

09/07/25

TYS
4h 13m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
6h 54m
CLT

09/14/25

TYS
$378
American Airlines Logo
American Airlines

09/07/25

TYS
4h 13m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
5h 30m
CLT

09/14/25

TYS
$378
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$378
American Airlines Logo
American Airlines

09/07/25

TYS
3h 53m
MIA

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 7m
CLT

09/15/25

TYS
$426
American Airlines Logo
American Airlines

09/07/25

TYS
3h 53m
MIA

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 51m
MIA

09/14/25

TYS
$426
American Airlines Logo
American Airlines

09/07/25

TYS
4h 22m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
3h 45m
CLT

09/14/25

TYS
$426
American Airlines Logo
American Airlines

09/07/25

TYS
3h 53m
MIA

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
3h 45m
CLT

09/14/25

TYS
$426
American Airlines Logo
American Airlines

09/07/25

TYS
5h 32m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 51m
MIA

09/14/25

TYS
$426
American Airlines Logo
American Airlines

09/07/25

TYS
4h 22m
CLT

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 51m
MIA

09/14/25

TYS
$426
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
16h 17m
IAD

09/14/25

TYS
$441
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
26h 28m
ORD

09/15/25

TYS
$446
American Airlines Logo
American Airlines

09/07/25

TYS
3h 53m
MIA

09/07/25

TPA
American Airlines Logo
American Airlines

09/14/25

TPA
4h 32m
CLT

09/14/25

TYS
$456
Frontier Airlines Logo
Frontier Airlines

09/07/25

TYS
12h 23m
DEN

09/08/25

TPA
Frontier Airlines Logo
Frontier Airlines

09/14/25

TPA
25h 41m
DEN

09/15/25

TYS
$476
Frontier Airlines Logo
Frontier Airlines

09/07/25

TYS
12h 23m
DEN

09/08/25

TPA
Frontier Airlines Logo
Frontier Airlines

09/14/25

TPA
9h 41m
DEN

09/14/25

TYS
$476
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
5h 29m
IAD

09/14/25

TYS
$504
United Airlines Logo
United Airlines

09/07/25

TYS
18h 53m
IAD

09/08/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$511
United Airlines Logo
United Airlines

09/07/25

TYS
9h 20m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$511
United Airlines Logo
United Airlines

09/07/25

TYS
14h 5m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$541
United Airlines Logo
United Airlines

09/07/25

TYS
8h 2m
ORD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$551
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
6h 30m
ORD

09/14/25

TYS
$551
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
6h 28m
IAH

09/14/25

TYS
$551
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
5h 40m
IAD

09/14/25

TYS
$551
United Airlines Logo
United Airlines

09/07/25

TYS
5h 22m
IAD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
10h 10m
ORD

09/14/25

TYS
$553
United Airlines Logo
United Airlines

09/07/25

TYS
14h 2m
IAH

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$571
United Airlines Logo
United Airlines

09/07/25

TYS
12h 34m
ORD

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$608
United Airlines Logo
United Airlines

09/07/25

TYS
8h 30m
IAH

09/07/25

TPA
United Airlines Logo
United Airlines

09/14/25

TPA
7h
IAD

09/14/25

TYS
$610

Top Deals on flights from Knoxville to Tampa

Knoxville, US (TYS) - Tampa, US (TPA)

 Logo

Oct 29

TYS
5h 5m
ATL

Oct 29

TPA

as low as

$149

Knoxville, US (TYS) - Tampa, US (TPA)

 Logo

Oct 27

TYS
5h 9m
ATL

Oct 27

TPA

as low as

$186

Knoxville, US (TYS) - Tampa, US (TPA)

American Airlines Logo
American Airlines

Nov 1

TYS
25h 4m
LGA

Nov 2

TPA

as low as

$244

Knoxville, US (TYS) - Tampa, US (TPA)

United Airlines Logo
United Airlines

Oct 31

TYS
19h 57m
IAD

Nov 1

TPA

as low as

$252

Knoxville, US (TYS) - Tampa, US (TPA)

American Airlines Logo
American Airlines

Oct 17

TYS
3h 32m
CLT

Oct 18

TPA

as low as

$273

Knoxville, US (TYS) - Tampa, US (TPA)

United Airlines Logo
United Airlines

Nov 1

TYS
6h 42m
ORD

Nov 1

TPA

as low as

$273

Knoxville, US (TYS) - Tampa, US (TPA)

American Airlines Logo
American Airlines

Dec 8

TYS
6h 24m
MIA

Dec 8

TPA

as low as

$273

Knoxville, US (TYS) - Tampa, US (TPA)

American Airlines Logo
American Airlines

Dec 7

TYS
5h 10m
CLT

Dec 7

TPA

as low as

$273

Knoxville, US (TYS) - Tampa, US (TPA)

United Airlines Logo
United Airlines

Sep 6

TYS
5h 13m
IAD

Sep 7

TPA

as low as

$273

Knoxville, US (TYS) - Tampa, US (TPA)

United Airlines Logo
United Airlines

Oct 18

TYS
7h 59m
ORD

Oct 18

TPA

as low as

$273

Knoxville, US (TYS) - Tampa, US (TPA)

United Airlines Logo
United Airlines

Aug 11

TYS
6h 7m
IAH

Aug 11

TPA

as low as

$385

Knoxville, US (TYS) - Tampa, US (TPA)

American Airlines Logo
American Airlines

Dec 8

TYS
14h 23m
DCA
ORD

Dec 8

TPA

as low as

$397

Frequently Asked Questions

What is the time difference between destination and arrival?
The time difference between Knoxville and Tampa is one hour, with Knoxville in the Central Time Zone and Tampa in the Eastern Time Zone.
Is there a direct flight from Knoxville to Tampa?
There is no direct flight from Knoxville to Tampa. The available options are 1 stop flights with American Airlines for $348, United Airlines for $378, and Frontier Airlines for $476.
Are there convenient layover flights from Knoxville to Tampa?
Yes, convenient layover flights from Knoxville to Tampa include American Airlines for $348 (1 stop, layover in Charlotte), United Airlines for $378 (1 stop, layover in Washington), and Frontier Airlines for $476 (1 stop, layover in Denver).
What are the most convenient layover airports for my flight?
Convenient layover airports for your flight include Charlotte Douglas International, Washington Dulles, and Denver International. These airports are serviced by American Airlines, United Airlines, and Frontier Airlines, respectively.
What is the cheapest and fastest flight from Knoxville to Tampa?
The cheapest flight is with American Airlines at $348 (4h 13m, layover in Charlotte). The fastest is also with American Airlines at $426 (3h 53m, layover in Miami).
What are all possible destination arrival airports?
Possible destination arrival airports include Tampa International Airport, Charlotte Douglas International Airport, Miami International Airport, Washington Dulles Airport, and Denver International Airport.