Santiago — flights from St. Louis to Santiago

Flight Deals from St. Louis to Santiago from $402

Name: Residence Inn by Marriott Santiago de los Caballeros
Rating: 8.7

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Top flight deals from leading airlines:

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Good to Know

Essential information to help you plan your flight from St. Louis to Santiago.

Cheapest Flight Round-trip

$639

Cheapest price found on Priceline for this route in the last 16 days. Found 8 days ago.

$130 below the typical $769 round-trip on this route.

Outbound · Nov 10

6:02 amSTLSt Louis Lambert International Airport

3:16 pmSTICibao International Airport

7h 14m · 1 stop via Philadelphia (PHL)

Return · Nov 17

5:08 pmSTICibao International Airport

8:42 amSTLSt Louis Lambert International Airport

17h 34m · 2 stops via Miami (MIA), New York City (LGA)

Cheapest Flight One-way

$402

Lowest one-way price found on Priceline for this route in the last 16 days. Found 12 days ago.

The typical one-way fare on this route is $521.

Outbound · Oct 29

5:00 amSTLSt Louis Lambert International Airport

2:12 pmSTICibao International Airport

8h 12m · 1 stop via Miami (MIA)

Fastest Flights

$742

Fastest flight found on Priceline for this route in the last 16 days. Found 5 hours ago.

You could save 8h 56m of travel time for just $103 more.

Outbound · Nov 13

5:02 amSTLSt Louis Lambert International Airport

1:26 pmSTICibao International Airport

6h 24m · 1 stop via Miami (MIA)

Return · Nov 20

2:22 pmSTICibao International Airport

9:50 pmSTLSt Louis Lambert International Airport

9h 28m · 1 stop via Miami (MIA)

Good deal price

$704

A round-trip at or under $704 is a good deal on this route right now.

75% of the fares we found on this route cost more; only a quarter cost less.

Best time to fly

Afternoons

Afternoon departures average $713 on this route, the lowest of any time of day.

$61 less than the average departure, which is $774.

Priceline Phone Deals

Book with an agent for great rates!

Call now!1 (888) 775-6158

American Airlinesfound Oct 12

11/10/26

6:02 am

STL

7h 14mPHL

11/10/26

3:16 pm

STI

11/17/26

5:08 pm

STI

17h 34mMIALGA

11/18/26

8:42 am

STL

^$639

American Airlinesfound Oct 12

11/10/26

6:02 am

STL

7h 14mPHL

11/10/26

3:16 pm

STI

11/17/26

5:08 pm

STI

18h 39mMIACLT

11/18/26

9:47 am

STL

^$639

American Airlinesfound Oct 12

11/10/26

6:02 am

STL

7h 14mPHL

11/10/26

3:16 pm

STI

11/17/26

5:08 pm

STI

18h 47mMIADCA

11/18/26

9:55 am

STL

^$639

American Airlinesfound Oct 12

11/10/26

6:02 am

STL

7h 14mPHL

11/10/26

3:16 pm

STI

11/17/26

5:08 pm

STI

18h 47mMIADCA

11/18/26

9:55 am

STL

^$639

BUNDLE + SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

United Airlinesfound Oct 12

11/10/26

11:29 am

STL

10h 22mEWR

11/10/26

11:51 pm

STI

11/17/26

12:55 pm

STI

10h 57mEWR

11/17/26

9:52 pm

STL

^$766

American Airlinesfound Oct 12

11/10/26

5:00 am

STL

9h 8mMIA

11/10/26

4:08 pm

STI

11/17/26

5:08 pm

STI

17h 34mMIALGA

11/18/26

8:42 am

STL

^$639

United Airlinesfound Oct 12

11/10/26

11:29 am

STL

10h 22mEWR

11/10/26

11:51 pm

STI

11/17/26

6:00 am

STI

12h 17mEWR

11/17/26

4:17 pm

STL

^$766

American Airlinesfound Oct 12

11/10/26

6:02 am

STL

7h 14mPHL

11/10/26

3:16 pm

STI

11/17/26

5:08 pm

STI

19h 45mMIAORD

11/18/26

10:53 am

STL

^$639

United Airlinesfound Oct 12

11/10/26

9:59 am

STL

11h 52mEWR

11/10/26

11:51 pm

STI

11/17/26

12:55 pm

STI

10h 57mEWR

11/17/26

9:52 pm

STL

^$766

American Airlinesfound Oct 12

11/10/26

6:02 am

STL

7h 14mPHL

11/10/26

3:16 pm

STI

11/17/26

5:08 pm

STI

19h 45mMIAORD

11/18/26

10:53 am

STL

^$639

Top Deals on flights from St. Louis to Santiago

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:00 am

STL

8h 12m1 stop · MIA

Oct 29

2:12 pm

STI

Search More

as low as

^$402

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:27 pm

STL

19h 45m2 stops · ORD, MIA

Oct 30

2:12 pm

STI

Search More

as low as

^$408

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:40 pm

STL

18h 38m1 stop · PHL

Oct 30

1:18 pm

STI

Search More

as low as

^$422

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

11:21 am

STL

24h 57m1 stop · PHL

Oct 30

1:18 pm

STI

Search More

as low as

^$422

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

6:07 pm

STL

19h 5m1 stop · MIA

Oct 30

2:12 pm

STI

Search More

as low as

^$427

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:28 am

STL

7h 44m2 stops · CLT, MIA

Oct 29

2:12 pm

STI

Search More

as low as

^$447

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:40 pm

STL

19h 32m2 stops · PHL, MIA

Oct 30

2:12 pm

STI

Search More

as low as

^$453

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:40 pm

STL

19h 32m2 stops · PHL, MIA

Oct 30

2:12 pm

STI

Search More

as low as

^$453

St. Louis, US (STL) - Santiago, DO (STI)

United Airlines

Oct 29

11:29 am

STL

10h 22m1 stop · EWR

Oct 29

10:51 pm

STI

Search More

as low as

^$469

St. Louis, US (STL) - Santiago, DO (STI)

United Airlines

Oct 29

9:59 am

STL

11h 52m1 stop · EWR

Oct 29

10:51 pm

STI

Search More

as low as

^$469

St. Louis, US (STL) - Santiago, DO (STI)

United Airlines

Oct 29

6:09 am

STL

15h 42m1 stop · EWR

Oct 29

10:51 pm

STI

Search More

as low as

^$469

St. Louis, US (STL) - Santiago, DO (STI)

American Airlines

Oct 29

5:08 pm

STL

20h 4m2 stops · DCA, MIA

Oct 30

2:12 pm

STI

Search More

as low as

^$482

See all 12 dealsShow fewer deals

Best Santiago Hotel + Flight Packages

St. Louis - Santiago packages

Round-trip flight from St. Louis

STL to STI

Hodelpa Garden Court

Santiago, Autopista Duarte Km. 9

8.9353 Reviews3.5-Star Hotel

14% Package Savings

^$1,084/person

$2,519 $2,167 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to STI

Hodelpa Gran Almirante

Santiago, Avenida Salvador Estrella Sadhala

9429 Reviews3.5-Star Hotel

14% Package Savings

^$1,123/person

$2,615 $2,245 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to STI

Hodelpa Centro Plaza Hotel

Santiago, C/ Mella 54 Esq. Del Sol Apdo. 459

8.7431 Reviews3-Star Hotel

11% Package Savings

^$979/person

$2,200 $1,958 total

Incl. Flight + Hotel

Hotel Santiago, Curio Collection By Hilton

Round-trip flight from St. Louis

STL to STI

Hotel Santiago, Curio Collection By Hilton

Santiago De Los Caballeros, Avenida Juan Pablo Duarte Esquina Estrella Sadhala

9.1131 Reviews4-Star Hotel

2% Package Savings

^$1,195/person

$2,442 $2,390 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to STI

AC Hotel Santiago de los Caballeros

Santiago De Los Caballeros, Calle Del Sol # 32-34, La Zurza Ii, Zona Monumental

8.882 Reviews3-Star Hotel

6% Package Savings

^$1,397/person

$2,964 $2,794 total

Incl. Flight + Hotel

Residence Inn by Marriott Santiago de los Caballeros

Round-trip flight from St. Louis

STL to STI

Residence Inn by Marriott Santiago de los Caballeros

Santiago De Los Caballeros, Autopista Duarte Km 2.8

8.750 Reviews4-Star Hotel

7% Package Savings

^$1,293/person

$2,770 $2,586 total

Incl. Flight + Hotel

Hampton by Hilton Santiago de los Caballeros

Round-trip flight from St. Louis

STL to STI

Hampton by Hilton Santiago de los Caballeros

Santiago De Los Caballeros, Calle R C Tolentino

9.232 Reviews3-Star Hotel

8% Package Savings

^$1,246/person

$2,696 $2,492 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to STI

Nohian Collection Hotels

Santiago De Los Caballeros, Julio O. García & Rep. Del Libano 26

9.135 Reviews5-Star Hotel

^$1,263/person

$2,525 total

Incl. Flight + Hotel

Best Santiago Hotel + Flight + Car Packages

St. Louis - Santiago packages

Round-trip flight from St. Louis

STL to STI

Hotel Santiago, Curio Collection By Hilton

Santiago De Los Caballeros, Avenida Juan Pablo Duarte Esquina Estrella Sadhala

9.1131 Reviews4-Star Hotel

Rental car included

Pick-up in STI

2% Package Savings

^$1,261/person

$2,573 $2,521 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

AC Hotel Santiago de los Caballeros

Santiago De Los Caballeros, Calle Del Sol # 32-34, La Zurza Ii, Zona Monumental

8.882 Reviews3-Star Hotel

Rental car included

Pick-up in STI

5% Package Savings

^$1,463/person

$3,093 $2,925 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

Residence Inn by Marriott Santiago de los Caballeros

Santiago De Los Caballeros, Autopista Duarte Km 2.8

8.750 Reviews4-Star Hotel

Rental car included

Pick-up in STI

6% Package Savings

^$1,359/person

$2,902 $2,718 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

Hampton by Hilton Santiago de los Caballeros

Santiago De Los Caballeros, Calle R C Tolentino

9.232 Reviews3-Star Hotel

Rental car included

Pick-up in STI

7% Package Savings

^$1,312/person

$2,828 $2,624 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

Nohian Collection Hotels

Santiago De Los Caballeros, Julio O. García & Rep. Del Libano 26

9.135 Reviews5-Star Hotel

Rental car included

Pick-up in STI

^$1,329/person

$2,657 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

Hodelpa Garden Court

Santiago, Autopista Duarte Km. 9

8.9353 Reviews3.5-Star Hotel

Rental car included

Pick-up in STI

13% Package Savings

^$1,150/person

$2,651 $2,299 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

Hodelpa Gran Almirante

Santiago, Avenida Salvador Estrella Sadhala

9429 Reviews3.5-Star Hotel

Rental car included

Pick-up in STI

13% Package Savings

^$1,189/person

$2,747 $2,377 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to STI

Hodelpa Centro Plaza Hotel

Santiago, C/ Mella 54 Esq. Del Sol Apdo. 459

8.7431 Reviews3-Star Hotel

Rental car included

Pick-up in STI

10% Package Savings

^$1,045/person

$2,331 $2,089 total

Incl. Flight + Hotel + Car

When is the best time of day to fly?

Afternoon (2pm - 5pm) is the cheapest time of day to fly from St. Louis to Santiago. At $713 it is 8% cheaper than the average time. Midday (12pm - 2pm) is the most expensive time, 9% above average.

Show the data

When is the best time of day to fly?
Time of day	Average fare
Morning	$778
Midday	$841
Afternoon	$713
Evening	$763

What do round-trip flights from St. Louis to Santiago cost?

Share of fares in each price range.

Show the data

What do round-trip flights from St. Louis to Santiago cost?
Price range	Share of fares
$600 to $650	13%
$650 to $700	6%
$700 to $750	14%
$750 to $800	35%
$800 to $850	9%
$850 to $900	14%
$900 and up	8%

Flight Deals from St. Louis to Santiago from $402

Good to Know

Top Deals on flights from St. Louis to Santiago

Best Santiago Hotel + Flight Packages

Best Santiago Hotel + Flight + Car Packages

When is the best time of day to fly?

What do round-trip flights from St. Louis to Santiago cost?

Flights to Santiago