$292 Flight Deals from San Francisco to Panama City

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Stops

Nonstop
from $658
Up to 1 stop
$558
Up to 2 stops
$554

Airlines

American Airlines
$657
AVIANCA
$701
COPA Airlines
$706
Delta Air Lines
$674
United Airlines
$554

Cabin Class

Economy
$554

Departure Airports

San Francisco International Airport
$554

Arrival Airports

Tocumen International Airport
$554

Layover Airports

Dallas Fort Worth International Airport
$1365
Denver International Airport
$554
George Bush Intercontinental Houston Airport
$554
Hartsfield Jackson Atlanta International Airport
$674
Juan Santamaria International Airport
$861
Los Angeles International Airport
$1365
Miami International Airport
$657
Monseñor Óscar Arnulfo Romero International Airport
$629
Phoenix Sky Harbor International Airport
$700

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE

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On average save $240 per traveler

United Airlines

11/19/25

8:45am

SFO

10h 4m

Direct

11/19/25

6:49pm

PTY

United Airlines

11/26/25

4:41pm

PTY

24h 57m

IAH

DEN

11/27/25

5:38pm

SFO

^$554

United Airlines

11/19/25

5:15am

SFO

14h 23m

IAH

11/19/25

7:38pm

PTY

United Airlines

11/26/25

4:41pm

PTY

17h 24m

IAH

DEN

11/27/25

10:05am

SFO

^$554

United Airlines

11/19/25

8:45am

SFO

10h 4m

Direct

11/19/25

6:49pm

PTY

United Airlines

11/26/25

4:41pm

PTY

19h 37m

IAH

11/27/25

12:18pm

SFO

^$558

United Airlines

11/07/25

4:10pm

SFO

22h 35m

IAH

11/08/25

2:45pm

PTY

United Airlines

11/15/25

4:41pm

PTY

17h 24m

IAH

DEN

11/16/25

10:05am

SFO

^$569

United Airlines

11/07/25

8:45am

SFO

10h 4m

Direct

11/07/25

6:49pm

PTY

United Airlines

11/15/25

4:41pm

PTY

17h 24m

IAH

DEN

11/16/25

10:05am

SFO

^$569

United Airlines

11/07/25

8:45am

SFO

10h 4m

Direct

11/07/25

6:49pm

PTY

United Airlines

11/15/25

4:41pm

PTY

19h 37m

IAH

11/16/25

12:18pm

SFO

^$574

United Airlines

11/11/25

11:15pm

SFO

15h 30m

SAL

11/12/25

2:45pm

PTY

United Airlines

11/15/25

8:55am

PTY

11h 58m

IAH

DEN

11/15/25

8:53pm

SFO

^$629

United Airlines

11/13/25

8:45am

SFO

10h 4m

Direct

11/13/25

6:49pm

PTY

United Airlines

11/19/25

8:55am

PTY

27h 23m

IAH

11/20/25

12:18pm

SFO

^$633

United Airlines

11/12/25

8:45am

SFO

10h 4m

Direct

11/12/25

6:49pm

PTY

United Airlines

11/17/25

8:55am

PTY

27h 23m

IAH

11/18/25

12:18pm

SFO

^$633

American Airlines

10/25/25

11:48pm

SFO

12h 37m

MIA

10/26/25

12:25pm

PTY

American Airlines

11/15/25

2:45pm

PTY

8h 11m

MIA

11/15/25

10:56pm

SFO

^$657

United Airlines

11/19/25

8:45am

SFO

10h 4m

Direct

11/19/25

6:49pm

PTY

United Airlines

11/26/25

3:35pm

PTY

4h 54m

Direct

11/26/25

8:29pm

SFO

^$658

United Airlines

11/07/25

8:45am

SFO

10h 4m

Direct

11/07/25

6:49pm

PTY

United Airlines

11/15/25

3:35pm

PTY

4h 54m

Direct

11/15/25

8:29pm

SFO

^$658

Delta Air Lines

11/03/25

3:15pm

SFO

22h 32m

ATL

11/04/25

1:47pm

PTY

Delta Air Lines

11/17/25

3:17pm

PTY

28h 47m

ATL

11/18/25

8:04pm

SFO

^$674

Delta Air Lines

11/12/25

9:30pm

SFO

16h 22m

ATL

11/13/25

1:52pm

PTY

Delta Air Lines

11/19/25

3:17pm

PTY

28h 47m

ATL

11/20/25

8:04pm

SFO

^$689

Delta Air Lines

11/11/25

9:30pm

SFO

16h 22m

ATL

11/12/25

1:52pm

PTY

Delta Air Lines

11/15/25

8:05am

PTY

14h 53m

ATL

11/15/25

10:58pm

SFO

^$693

American Airlines

11/12/25

11:59pm

SFO

13h 21m

MIA

11/13/25

1:20pm

PTY

American Airlines

11/17/25

4:20pm

PTY

17h 6m

MIA

PHX

11/18/25

9:26am

SFO

^$700

AVIANCA

11/11/25

11:15pm

SFO

15h 30m

SAL

11/12/25

2:45pm

PTY

AVIANCA

11/15/25

3:40pm

PTY

6h 15m

SAL

11/15/25

9:55pm

SFO

^$701

COPA Airlines

11/19/25

12:36am

SFO

10h 10m

Direct

11/19/25

10:46am

PTY

COPA Airlines

11/26/25

6:27pm

PTY

4h 50m

Direct

11/26/25

11:17pm

SFO

^$706

COPA Airlines

11/08/25

12:55am

SFO

9h 56m

Direct

11/08/25

10:51am

PTY

COPA Airlines

11/15/25

6:50pm

PTY

4h 50m

Direct

11/15/25

11:40pm

SFO

^$706

COPA Airlines

11/07/25

12:36am

SFO

10h 10m

Direct

11/07/25

10:46am

PTY

COPA Airlines

11/15/25

6:27pm

PTY

4h 50m

Direct

11/15/25

11:17pm

SFO

^$706

COPA Airlines

11/03/25

12:55am

SFO

9h 56m

Direct

11/03/25

10:51am

PTY

COPA Airlines

11/17/25

6:50pm

PTY

4h 50m

Direct

11/17/25

11:40pm

SFO

^$706

AVIANCA

11/12/25

1:20pm

SFO

21h 5m

SAL

11/13/25

10:25am

PTY

AVIANCA

11/17/25

3:40pm

PTY

6h 15m

SAL

11/17/25

9:55pm

SFO

^$711

AVIANCA

11/13/25

11:15pm

SFO

15h 30m

SAL

11/14/25

2:45pm

PTY

AVIANCA

11/19/25

3:40pm

PTY

6h 15m

SAL

11/19/25

9:55pm

SFO

^$723

AVIANCA

11/07/25

11:15pm

SFO

15h 30m

SAL

11/08/25

2:45pm

PTY

AVIANCA

11/15/25

3:40pm

PTY

6h 15m

SAL

11/15/25

9:55pm

SFO

^$723

American Airlines

11/19/25

11:59pm

SFO

15h 21m

MIA

11/20/25

3:20pm

PTY

American Airlines

11/26/25

2:45pm

PTY

8h 11m

MIA

11/26/25

10:56pm

SFO

^$762

Delta Air Lines

11/20/25

9:30pm

SFO

16h 22m

ATL

11/21/25

1:52pm

PTY

Delta Air Lines

11/24/25

3:17pm

PTY

28h 47m

ATL

11/25/25

8:04pm

SFO

^$853

AVIANCA

11/13/25

11:15pm

SFO

15h 30m

SAL

11/14/25

2:45pm

PTY

AVIANCA

11/19/25

1:30pm

PTY

8h 25m

SJO

SAL

11/19/25

9:55pm

SFO

^$861

American Airlines

11/22/25

7:11pm

SFO

18h 9m

LAX

MIA

11/23/25

1:20pm

PTY

American Airlines

11/29/25

2:45pm

PTY

8h 11m

MIA

11/29/25

10:56pm

SFO

^$1365

American Airlines

11/22/25

7:11pm

SFO

18h 9m

LAX

MIA

11/23/25

1:20pm

PTY

American Airlines

11/29/25

4:20pm

PTY

17h 40m

MIA

DFW

11/30/25

10:00am

SFO

^$1365

AVIANCA

11/22/25

11:15pm

SFO

11h 10m

SAL

11/23/25

10:25am

PTY

AVIANCA

11/29/25

1:30pm

PTY

22h 30m

SJO

SAL

11/30/25

12:00pm

SFO

^$1392

Top Deals on flights from San Francisco to Panama City

San Francisco, US (SFO) - Panama City, PA (PTY)

COPA Airlines

Oct 8

10:30am

SFO

18h 55m

SAN

Oct 9

5:25am

PTY

as low as

^$292

San Francisco, US (SFO) - Panama City, PA (PTY)

AVIANCA

Feb 10

11:15pm

SFO

15h 30m

SAL

Feb 11

2:45pm

PTY

as low as

^$320

San Francisco, US (SFO) - Panama City, PA (PTY)

AVIANCA

Sep 23

2:20pm

SFO

24h 20m

SAL

MDE

Sep 24

2:40pm

PTY

as low as

^$330

San Francisco, US (SFO) - Panama City, PA (PTY)

AVIANCA

Feb 8

11:15pm

SFO

25h 5m

SAL

BOG

Feb 10

12:20am

PTY

as low as

^$330

San Francisco, US (SFO) - Panama City, PA (PTY)

COPA Airlines

Aug 11

10:07pm

SFO

12h 28m

LAX

Aug 12

10:35am

PTY

as low as

^$383

San Francisco, US (SFO) - Panama City, PA (PTY)

American Airlines

Aug 29

11:59pm

SFO

14h 31m

MIA

Aug 30

2:30pm

PTY

as low as

^$558

San Francisco, US (SFO) - Panama City, PA (PTY)

American Airlines

Aug 29

12:45am

SFO

13h 45m

DFW

MIA

Aug 29

2:30pm

PTY

as low as

^$684

San Francisco, US (SFO) - Panama City, PA (PTY)

American Airlines

Jan 12

12:27am

SFO

15h 8m

CLT

MIA

Jan 12

3:35pm

PTY

as low as

^$703

San Francisco, US (SFO) - Panama City, PA (PTY)

United Airlines

Aug 29

4:15pm

SFO

21h 59m

IAH

Aug 30

2:14pm

PTY

as low as

^$743

San Francisco, US (SFO) - Panama City, PA (PTY)

United Airlines

Dec 26

8:45am

SFO

10h 4m

Direct

Dec 26

6:49pm

PTY

as low as

^$789

San Francisco, US (SFO) - Panama City, PA (PTY)

Delta Air Lines

Sep 25

10:50pm

SFO

14h 5m

ATL

Sep 26

12:55pm

PTY

as low as

^$853

San Francisco, US (SFO) - Panama City, PA (PTY)

COPA Airlines

Nov 13

7:00am

SFO

13h

AUS

Nov 13

8:00pm

PTY

as low as

^$964

Frequently Asked Questions

Is there a direct flight from San Francisco to Panama City?

Yes, there are direct flights available from San Francisco International Airport to Tocumen International Airport. The airlines offering direct flights are United Airlines at $554 and COPA Airlines at $706.

Are there convenient layover flights from San Francisco to Panama City?

Yes, convenient layover flights from San Francisco to Panama City include: United Airlines at $554 (14h 23m), American Airlines at $657 (12h 37m), Delta Air Lines at $674 (22h 32m), AVIANCA at $701 (15h 30m), and COPA Airlines at $3458 (13h).

What are the most convenient layover airports for my flight from San Francisco to Panama City?

The most convenient layover airports are George Bush Intercontinental (United), Miami International (American), Hartsfield Jackson Atlanta (Delta), Monseñor Óscar Arnulfo Romero (AVIANCA), and Austin Bergstrom (COPA).

What is the cheapest and fastest flight from San Francisco to Panama City?

The cheapest flight is with United Airlines for $554, taking 14 hours 23 minutes with 1 stop. The fastest flight is with COPA Airlines for $706, taking 9 hours 56 minutes non-stop.

What are all possible destination arrival airports?

The possible destination arrival airport is Tocumen International Airport in Panama City.

What is the time difference between destination and arrival?

The time difference between San Francisco, CA, and Panama City is typically 2 hours, with Panama City being ahead of San Francisco.

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Flight Deals from San Francisco to Panama City from $292

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Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from San Francisco to Panama City

Frequently Asked Questions

Flights to Panama City