$226 Flight Deals from San Antonio to Panama City

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Stops

Up to 1 stop
$642
Up to 2 stops
$647

Airlines

American Airlines
$642

Cabin Class

Economy
$642

Departure Airports

San Antonio International Airport
$642

Arrival Airports

Tocumen International Airport
$642

Layover Airports

Dallas Fort Worth International Airport
$647
Miami International Airport
$642

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BUNDLE & SAVE

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On average save $240 per traveler

American Airlines

11/20/25

5:25am

SAT

8h 11m

MIA

11/20/25

1:36pm

PTY

American Airlines

11/24/25

2:43pm

PTY

9h 14m

MIA

11/24/25

11:57pm

SAT

^$642

American Airlines

11/20/25

5:25am

SAT

8h 11m

MIA

11/20/25

1:36pm

PTY

American Airlines

11/24/25

2:43pm

PTY

18h 58m

MIA

DFW

11/25/25

9:41am

SAT

^$647

American Airlines

11/20/25

7:30pm

SAT

18h 6m

DFW

MIA

11/21/25

1:36pm

PTY

American Airlines

11/24/25

2:43pm

PTY

17h 41m

MIA

DFW

11/25/25

8:24am

SAT

^$647

American Airlines

10/31/25

6:12pm

SAT

19h 51m

MIA

11/01/25

2:03pm

PTY

American Airlines

11/15/25

2:43pm

PTY

9h 14m

MIA

11/15/25

11:57pm

SAT

^$663

American Airlines

10/31/25

6:12pm

SAT

19h 51m

MIA

11/01/25

2:03pm

PTY

American Airlines

11/15/25

2:43pm

PTY

18h 58m

MIA

DFW

11/16/25

9:41am

SAT

^$668

American Airlines

10/31/25

5:30am

SAT

8h 33m

MIA

10/31/25

2:03pm

PTY

American Airlines

11/15/25

2:43pm

PTY

9h 14m

MIA

11/15/25

11:57pm

SAT

^$748

Top Deals on flights from San Antonio to Panama City

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

7:10am

SAT

7h 4m

IAH

Sep 10

2:14pm

PTY

as low as

^$226

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

5:30am

SAT

8h 44m

IAH

Sep 10

2:14pm

PTY

as low as

^$226

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

5:30am

SAT

13h 7m

IAH

Sep 10

6:37pm

PTY

as low as

^$226

San Antonio, US (SAT) - Panama City, PA (PTY)

American Airlines

Sep 10

5:29am

SAT

7h 26m

MIA

Sep 10

12:55pm

PTY

as low as

^$565

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

7:45am

SAT

12h 25m

SFO

Sep 10

8:10pm

PTY

as low as

^$2528

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

6:30am

SAT

13h 57m

MCO

Sep 10

8:27pm

PTY

as low as

^$2689

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

5:30am

SAT

29h 11m

SFO

Sep 11

10:41am

PTY

as low as

^$2748

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

1:20pm

SAT

24h 30m

EWR

Sep 11

1:50pm

PTY

as low as

^$3639

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

6:30am

SAT

14h 5m

ORD

Sep 10

8:35pm

PTY

as low as

^$3674

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

12:00pm

SAT

18h 13m

IAD

Sep 11

6:13am

PTY

as low as

^$3674

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

8:55am

SAT

21h 18m

IAD

Sep 11

6:13am

PTY

as low as

^$3674

San Antonio, US (SAT) - Panama City, PA (PTY)

Sep 10

12:57pm

SAT

24h 25m

ORD

Sep 11

1:22pm

PTY

as low as

^$3789

Frequently Asked Questions

Is there a direct flight from San Antonio to Panama City?

There is no direct flight from San Antonio to Panama City. The cheapest available option is with American Airlines, which offers a 1 stop flight for $642 with layovers at Miami International Airport.

Are there convenient layover flights from San Antonio to Panama City?

Yes, convenient layover flights from San Antonio to Panama City include a 1 stop flight with American Airlines priced at $642. A 2 stop option is also available with American Airlines for $647.

What are the most convenient layover airports for my flight from San Antonio to Panama City?

The most convenient layover airports for your flight are Miami International Airport and Dallas Fort Worth International Airport.

What is the cheapest and fastest flight from San Antonio to Panama City?

The cheapest flight is with American Airlines for $642, taking 8 hours 11 minutes with one stop in Miami. No faster option available.

What are all possible destination arrival airports?

The possible destination arrival airport is Tocumen International Airport, with layover options at Miami International Airport and Dallas Fort Worth International Airport for available flights from San Antonio.

What is the time difference between San Antonio and Panama City?

The time difference between San Antonio and Panama City is typically 1 hour, with Panama City being 1 hour ahead. However, please verify current local times due to possible daylight saving changes.

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Flight Deals from San Antonio to Panama City from $226

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from San Antonio to Panama City

Frequently Asked Questions

Flights to Panama City