$445 Flight Deals from Panama City to San Diego

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... and +100s more

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Stops

Up to 1 stop
$569
Up to 2 stops
$753

Airlines

American Airlines
$753
COPA Airlines
$3738
Delta Air Lines
$569

Cabin Class

Economy
$569

Departure Airports

Tocumen International Airport
$569

Arrival Airports

San Diego International Airport
$569

Layover Airports

Charlotte Douglas International Airport
$753
Dallas Fort Worth International Airport
$753
Harry Reid International Airport
$3738
Hartsfield Jackson Atlanta International Airport
$569
Miami International Airport
$753
Phoenix Sky Harbor International Airport
$811

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BUNDLE & SAVE

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On average save $240 per traveler

Delta Air Lines

10/31/25

2:21pm

PTY

8h 53m

ATL

10/31/25

11:14pm

SAN

Delta Air Lines

11/30/25

9:40pm

SAN

16h 12m

ATL

12/01/25

1:52pm

PTY

^$569

American Airlines

11/14/25

2:43pm

PTY

19h 15m

MIA

DFW

11/15/25

9:58am

SAN

American Airlines

12/01/25

10:02pm

SAN

15h 34m

CLT

MIA

12/02/25

1:36pm

PTY

^$753

American Airlines

11/14/25

2:43pm

PTY

7h 39m

MIA

11/14/25

10:22pm

SAN

American Airlines

12/01/25

10:02pm

SAN

15h 34m

CLT

MIA

12/02/25

1:36pm

PTY

^$753

American Airlines

11/09/25

2:43pm

PTY

19h 15m

MIA

DFW

11/10/25

9:58am

SAN

American Airlines

11/24/25

7:30pm

SAN

18h 6m

PHX

MIA

11/25/25

1:36pm

PTY

^$811

American Airlines

11/09/25

2:43pm

PTY

17h 51m

MIA

DFW

11/10/25

8:34am

SAN

American Airlines

11/24/25

10:35pm

SAN

15h 1m

MIA

11/25/25

1:36pm

PTY

^$811

American Airlines

11/14/25

2:43pm

PTY

7h 39m

MIA

11/14/25

10:22pm

SAN

American Airlines

12/01/25

10:35pm

SAN

15h 1m

MIA

12/02/25

1:36pm

PTY

^$825

American Airlines

11/13/25

2:43pm

PTY

7h 39m

MIA

11/13/25

10:22pm

SAN

American Airlines

11/30/25

10:35pm

SAN

15h 1m

MIA

12/01/25

1:36pm

PTY

^$825

American Airlines

11/09/25

2:43pm

PTY

20h 42m

MIA

11/10/25

11:25am

SAN

American Airlines

11/24/25

10:35pm

SAN

15h 1m

MIA

11/25/25

1:36pm

PTY

^$826

American Airlines

11/13/25

2:43pm

PTY

17h 51m

MIA

DFW

11/14/25

8:34am

SAN

American Airlines

11/30/25

10:35pm

SAN

15h 1m

MIA

12/01/25

1:36pm

PTY

^$830

American Airlines

10/31/25

3:15pm

PTY

20h 11m

MIA

11/01/25

11:26am

SAN

American Airlines

11/30/25

10:35pm

SAN

15h 1m

MIA

12/01/25

1:36pm

PTY

^$844

American Airlines

10/31/25

3:15pm

PTY

19h 41m

MIA

CLT

11/01/25

10:56am

SAN

American Airlines

11/30/25

10:35pm

SAN

15h 1m

MIA

12/01/25

1:36pm

PTY

^$859

American Airlines

11/13/25

2:43pm

PTY

17h 51m

MIA

DFW

11/14/25

8:34am

SAN

American Airlines

11/30/25

7:30pm

SAN

18h 6m

PHX

MIA

12/01/25

1:36pm

PTY

^$1007

American Airlines

10/31/25

3:15pm

PTY

19h 41m

MIA

CLT

11/01/25

10:56am

SAN

American Airlines

11/30/25

7:30pm

SAN

18h 6m

PHX

MIA

12/01/25

1:36pm

PTY

^$1044

COPA Airlines

08/28/25

6:00pm

PTY

14h 29m

LAS

08/29/25

8:29am

SAN

COPA Airlines

11/19/25

8:59pm

SAN

13h 17m

LAS

11/20/25

10:16am

PTY

^$3738

Top Deals on flights from Panama City to San Diego

Panama City, PA (PTY) - San Diego, US (SAN)

Nov 4

3:21pm

PTY

7h 53m

ATL

Nov 4

11:14pm

SAN

as low as

^$445

Panama City, PA (PTY) - San Diego, US (SAN)

Delta Air Lines

Nov 4

3:21pm

PTY

7h 53m

ATL

Nov 4

11:14pm

SAN

as low as

^$445

Panama City, PA (PTY) - San Diego, US (SAN)

COPA Airlines

Aug 15

1:15pm

PTY

4h 29m

Direct

Aug 15

5:44pm

SAN

as low as

^$459

Panama City, PA (PTY) - San Diego, US (SAN)

Nov 4

8:55am

PTY

6h 55m

IAH

Nov 4

3:50pm

SAN

as low as

^$472

Panama City, PA (PTY) - San Diego, US (SAN)

Nov 4

8:55am

PTY

10h 57m

IAH

LAX

Nov 4

7:52pm

SAN

as low as

^$476

Panama City, PA (PTY) - San Diego, US (SAN)

American Airlines

Aug 12

3:30pm

PTY

18h 17m

MIA

DFW

Aug 13

9:47am

SAN

as low as

^$492

Panama City, PA (PTY) - San Diego, US (SAN)

Dec 22

9:25am

PTY

8h 38m

ATL

Dec 22

6:03pm

SAN

as low as

^$581

Panama City, PA (PTY) - San Diego, US (SAN)

American Airlines

Aug 13

3:30pm

PTY

20h 12m

MIA

PHX

Aug 14

11:42am

CLD

as low as

^$583

Panama City, PA (PTY) - San Diego, US (SAN)

Oct 31

3:15pm

PTY

21h 30m

SFO

Nov 1

12:45pm

SAN

as low as

^$586

Panama City, PA (PTY) - San Diego, US (SAN)

American Airlines

Aug 28

3:30pm

PTY

19h 9m

MIA

CLT

Aug 29

10:39am

SAN

as low as

^$709

Panama City, PA (PTY) - San Diego, US (SAN)

Aug 13

3:40pm

PTY

28h 11m

SAL

LAX

Aug 14

7:51pm

SAN

as low as

^$730

Panama City, PA (PTY) - San Diego, US (SAN)

Jan 5

9:09am

PTY

28h 7m

SJD

Jan 6

1:16pm

SAN

as low as

^$863

Frequently Asked Questions

Are there convenient layover flights from Panama City to San Diego?

Yes, convenient 1 stop flights are available from Tocumen International Airport to San Diego International Airport with Delta Air Lines at $569, American Airlines at $753, and COPA Airlines at $3738. Additionally, a 2 stop flight is offered by American Airlines at $753.

What are the most convenient layover airports for my flight?

The most convenient layover airports for your flight from Panama City to San Diego are Hartsfield Jackson Atlanta International Airport (Delta), Miami International Airport (American Airlines), and Harry Reid International Airport (COPA Airlines).

What are the cheapest and fastest flights from Panama City to San Diego?

The cheapest flight is with Delta Air Lines for $569, taking 8 hours 53 minutes. The fastest flight is with American Airlines for $753, taking 7 hours 39 minutes.

What are all possible destination arrival airports?

The possible destination arrival airports from Tocumen International Airport to San Diego International Airport include San Diego International Airport, Hartsfield Jackson Atlanta International Airport, Miami International Airport, Dallas Fort Worth International Airport, and Harry Reid International Airport.

What is the time difference between destination and arrival?

The time difference between Panama City and San Diego is two hours, with San Diego being two hours behind Panama City.

Is there a direct flight from Panama City to San Diego?

There is no direct flight from Panama City to San Diego. The cheapest flight is with Delta Air Lines at $569 with one stop, and the fastest is with American Airlines at $753, also with one stop.

Flights to San Diego

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Origins

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Cabin Class

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Flight Deals from Panama City to San Diego from $445

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Panama City to San Diego

Frequently Asked Questions

Flights to San Diego