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Flight Deals from Detroit to Santiago from $652

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

  • Up to 1 stop
    $1243
  • Up to 2 stops
    $1219

Airlines

  • American Airlines
    $1219
  • COPA Airlines
    $1537
  • LATAM Airlines Group
    $1317

Cabin Class

  • Economy
    $1219

Departure Airports

  • Detroit Metropolitan Airport
    $1219

Arrival Airports

  • Comodoro Arturo Merino Benítez International Airport
    $1219

Layover Airports

  • Charlotte Douglas International Airport
    $1219
  • Chicago O Hare Airport
    $1219
  • El Dorado International Airport
    $1395
  • Hartsfield Jackson Atlanta International Airport
    $1348
  • Jorge Chávez International Airport
    $1348
  • Miami International Airport
    $1219
  • New York John F Kennedy Airport
    $1317
  • Orlando International Airport
    $1348
  • Philadelphia International Airport
    $1238
  • Tocumen International Airport
    $1537
  • Washington Dulles Airport
    $1537

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE

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On average save $240 per traveler
American Airlines Logo
American Airlines

08/03/25

DTW
16h 2m
CLT
MIA

08/04/25

SCL
American Airlines Logo
American Airlines

08/10/25

SCL
16h 47m
MIA
ORD

08/11/25

DTW
$1219
American Airlines Logo
American Airlines

08/03/25

DTW
16h 2m
CLT
MIA

08/04/25

SCL
American Airlines Logo
American Airlines

08/10/25

SCL
25h 40m
MIA

08/11/25

DTW
$1233
American Airlines Logo
American Airlines

07/10/25

DTW
16h 2m
CLT
MIA

07/11/25

SCL
American Airlines Logo
American Airlines

07/17/25

SCL
17h 27m
MIA
PHL

07/18/25

DTW
$1238
American Airlines Logo
American Airlines

08/03/25

DTW
24h 50m
MIA

08/04/25

SCL
American Airlines Logo
American Airlines

08/10/25

SCL
25h 40m
MIA

08/11/25

DTW
$1243
American Airlines Logo
American Airlines

07/10/25

DTW
16h 2m
CLT
MIA

07/11/25

SCL
American Airlines Logo
American Airlines

07/17/25

SCL
25h 25m
MIA

07/18/25

DTW
$1252
American Airlines Logo
American Airlines

07/10/25

DTW
24h 50m
MIA

07/11/25

SCL
American Airlines Logo
American Airlines

07/17/25

SCL
25h 25m
MIA

07/18/25

DTW
$1263
American Airlines Logo
American Airlines

07/18/25

DTW
16h 2m
CLT
MIA

07/19/25

SCL
American Airlines Logo
American Airlines

07/25/25

SCL
15h 18m
MIA
CLT

07/26/25

DTW
$1267
American Airlines Logo
American Airlines

08/03/25

DTW
35h 34m
CLT
MIA

08/05/25

SCL
American Airlines Logo
American Airlines

08/10/25

SCL
25h 40m
MIA

08/11/25

DTW
$1271
American Airlines Logo
American Airlines

07/11/25

DTW
15h 8m
PHL
MIA

07/12/25

SCL
American Airlines Logo
American Airlines

07/19/25

SCL
17h 27m
MIA
PHL

07/20/25

DTW
$1314
LATAM Airlines Group Logo
LATAM Airlines Group

07/10/25

DTW
24h 45m
JFK

07/11/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/17/25

SCL
25h 4m
JFK

07/18/25

DTW
$1317
American Airlines Logo
American Airlines

07/19/25

DTW
34h 12m
ORD
MIA

07/21/25

SCL
American Airlines Logo
American Airlines

07/26/25

SCL
17h 27m
MIA
PHL

07/27/25

DTW
$1327
American Airlines Logo
American Airlines

07/11/25

DTW
24h 50m
MIA

07/12/25

SCL
American Airlines Logo
American Airlines

07/19/25

SCL
25h 25m
MIA

07/20/25

DTW
$1340
American Airlines Logo
American Airlines

07/19/25

DTW
34h 12m
ORD
MIA

07/21/25

SCL
American Airlines Logo
American Airlines

07/26/25

SCL
25h 25m
MIA

07/27/25

DTW
$1343
LATAM Airlines Group Logo
LATAM Airlines Group

07/10/25

DTW
22h
MCO

07/11/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/17/25

SCL
19h 28m
LIM
ATL

07/17/25

DTW
$1348
American Airlines Logo
American Airlines

07/20/25

DTW
24h 50m
MIA

07/21/25

SCL
American Airlines Logo
American Airlines

07/27/25

SCL
25h 25m
MIA

07/28/25

DTW
$1353
LATAM Airlines Group Logo
LATAM Airlines Group

07/10/25

DTW
16h 27m
ATL
LIM

07/11/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/17/25

SCL
18h 8m
LIM
ATL

07/17/25

DTW
$1362
LATAM Airlines Group Logo
LATAM Airlines Group

07/20/25

DTW
14h 16m
JFK

07/21/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/27/25

SCL
17h 28m
BOG
MCO

07/28/25

DTW
$1395
LATAM Airlines Group Logo
LATAM Airlines Group

07/10/25

DTW
14h 16m
JFK

07/11/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/17/25

SCL
14h 26m
ATL

07/18/25

DTW
$1402
LATAM Airlines Group Logo
LATAM Airlines Group

07/20/25

DTW
18h 1m
ATL
LIM

07/21/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/27/25

SCL
17h 28m
BOG
MCO

07/28/25

DTW
$1411
LATAM Airlines Group Logo
LATAM Airlines Group

07/11/25

DTW
14h 16m
JFK

07/12/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/19/25

SCL
16h 10m
JFK

07/20/25

DTW
$1417
LATAM Airlines Group Logo
LATAM Airlines Group

07/20/25

DTW
14h 16m
JFK

07/21/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/27/25

SCL
16h 10m
JFK

07/28/25

DTW
$1417
LATAM Airlines Group Logo
LATAM Airlines Group

07/11/25

DTW
15h 56m
MIA
LIM

07/12/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/19/25

SCL
25h 4m
JFK

07/20/25

DTW
$1419
LATAM Airlines Group Logo
LATAM Airlines Group

08/03/25

DTW
35h 1m
ATL

08/05/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

08/10/25

SCL
17h 28m
BOG
MCO

08/11/25

DTW
$1428
LATAM Airlines Group Logo
LATAM Airlines Group

07/18/25

DTW
14h 16m
JFK

07/19/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/25/25

SCL
19h 27m
BOG
MIA

07/26/25

DTW
$1433
LATAM Airlines Group Logo
LATAM Airlines Group

07/18/25

DTW
15h 45m
ATL
MIA

07/19/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/25/25

SCL
19h 27m
BOG
MIA

07/26/25

DTW
$1453
LATAM Airlines Group Logo
LATAM Airlines Group

07/20/25

DTW
14h 16m
JFK

07/21/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/27/25

SCL
19h 19m
BOG
ATL

07/28/25

DTW
$1458
LATAM Airlines Group Logo
LATAM Airlines Group

07/20/25

DTW
18h 1m
ATL
LIM

07/21/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/27/25

SCL
19h 19m
BOG
ATL

07/28/25

DTW
$1474
COPA Airlines Logo
COPA Airlines

07/19/25

DTW
23h 36m
IAD
PTY

07/20/25

SCL
COPA Airlines Logo
COPA Airlines

07/26/25

SCL
22h 46m
PTY
IAD

07/27/25

DTW
$1537
LATAM Airlines Group Logo
LATAM Airlines Group

08/03/25

DTW
16h 26m
ATL
LIM

08/04/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

08/10/25

SCL
17h 28m
BOG
MCO

08/11/25

DTW
$1586
LATAM Airlines Group Logo
LATAM Airlines Group

07/11/25

DTW
17h 30m
MIA
LIM

07/12/25

SCL
LATAM Airlines Group Logo
LATAM Airlines Group

07/19/25

SCL
17h 28m
BOG
MCO

07/20/25

DTW
$1624

Top Deals on flights from Detroit to Santiago

Detroit, US (DTT) - Santiago, CL (SCL)

American Airlines Logo
American Airlines

Jul 18

DTW
16h 2m
CLT
MIA

Jul 19

SCL

as low as

$652

Detroit, US (DTT) - Santiago, CL (SCL)

American Airlines Logo
American Airlines

Jul 18

DTW
24h 50m
MIA

Jul 19

SCL

as low as

$815

Detroit, US (DTT) - Santiago, CL (SCL)

 Logo

Jul 18

DTW
34h 50m
IST

Jul 20

SCL

as low as

$2035

Detroit, US (DTT) - Santiago, CL (SCL)

 Logo

Jul 18

DTW
34h 25m
CDG

Jul 20

SCL

as low as

$4858

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