$216 Flight Deals from Denver to Santiago

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... and +100s more

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Stops

Up to 1 stop
$1100
Up to 2 stops
$1041

Airlines

American Airlines
$1320
Delta Air Lines
$1041
JetBlue
$1103
United Airlines
$1328

Cabin Class

Economy
$1041

Departure Airports

Denver International Airport
$1041

Arrival Airports

Cibao International Airport
$1041

Layover Airports

Charlotte Douglas International Airport
$1325
Chicago O Hare Airport
$3312
General Edward Lawrence Logan International Airport
$1103
Los Angeles International Airport
$1328
Miami International Airport
$1320
Minneapolis-St Paul International/Wold-Chamberlain Airport
$1041
New York John F Kennedy Airport
$1041
Newark Liberty Airport
$1328
St Louis Lambert International Airport
$4461

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

Delta Air Lines

11/21/25

6:55pm

DEN

30h 31m

MSP

JFK

11/23/25

1:26am

STI

Delta Air Lines

11/29/25

6:45am

STI

16h 1m

JFK

11/29/25

10:46pm

DEN

^$1041

Delta Air Lines

11/21/25

6:55pm

DEN

30h 31m

MSP

JFK

11/23/25

1:26am

STI

Delta Air Lines

11/29/25

6:45am

STI

15h 45m

JFK

MSP

11/29/25

10:30pm

DEN

^$1041

Delta Air Lines

11/21/25

11:59pm

DEN

13h 27m

JFK

11/22/25

1:26pm

STI

Delta Air Lines

11/29/25

9:59pm

STI

12h 53m

JFK

11/30/25

10:52am

DEN

^$1100

JetBlue

11/21/25

10:46am

DEN

18h 12m

BOS

11/22/25

4:58am

STI

JetBlue

11/29/25

5:05am

STI

17h 32m

JFK

11/29/25

10:37pm

DEN

^$1103

JetBlue

11/21/25

10:46am

DEN

35h 7m

BOS

JFK

11/22/25

9:53pm

STI

JetBlue

11/29/25

5:05am

STI

17h 32m

JFK

11/29/25

10:37pm

DEN

^$1111

JetBlue

11/21/25

10:46am

DEN

35h 7m

BOS

JFK

11/22/25

9:53pm

STI

JetBlue

11/29/25

6:59am

STI

15h 38m

BOS

JFK

11/29/25

10:37pm

DEN

^$1227

American Airlines

11/21/25

12:20am

DEN

20h 29m

MIA

11/21/25

8:49pm

STI

American Airlines

11/29/25

7:00am

STI

16h 1m

MIA

11/29/25

11:01pm

DEN

^$1320

American Airlines

11/21/25

12:20am

DEN

15h 10m

MIA

11/21/25

3:30pm

STI

American Airlines

11/29/25

4:36pm

STI

16h 47m

MIA

CLT

11/30/25

9:23am

DEN

^$1325

United Airlines

11/21/25

6:00am

DEN

17h 51m

EWR

11/21/25

11:51pm

STI

United Airlines

11/29/25

6:00am

STI

15h 23m

EWR

11/29/25

9:23pm

DEN

^$1328

American Airlines

11/21/25

7:15pm

DEN

25h 34m

LAX

MIA

11/22/25

8:49pm

STI

American Airlines

11/29/25

4:36pm

STI

16h 47m

MIA

CLT

11/30/25

9:23am

DEN

^$1328

United Airlines

11/21/25

6:00am

DEN

17h 51m

EWR

11/21/25

11:51pm

STI

United Airlines

11/29/25

12:52pm

STI

10h 23m

EWR

ORD

11/29/25

11:15pm

DEN

^$3312

United Airlines

11/21/25

7:21pm

DEN

19h 32m

ORD

EWR

11/22/25

2:53pm

STI

United Airlines

11/29/25

6:00am

STI

17h 5m

EWR

STL

11/29/25

11:05pm

DEN

^$4461

Top Deals on flights from Denver to Santiago

Denver, US (DEN) - Santiago, DO (STI)

JetBlue

Sep 10

11:25am

DEN

10h 2m

JFK

Sep 10

11:27pm

STI

as low as

^$216

Denver, US (DEN) - Santiago, DO (STI)

JetBlue

Sep 10

11:25am

DEN

19h 20m

JFK

Sep 11

8:45am

STI

as low as

^$257

Denver, US (DEN) - Santiago, DO (STI)

American Airlines

Sep 10

11:57pm

DEN

10h 30m

MIA

Sep 11

12:27pm

STI

as low as

^$314

Denver, US (DEN) - Santiago, DO (STI)

American Airlines

Sep 10

11:59pm

DEN

10h 28m

CLT

MIA

Sep 11

12:27pm

STI

as low as

^$314

Denver, US (DEN) - Santiago, DO (STI)

American Airlines

Sep 10

5:06pm

DEN

17h 21m

DFW

MIA

Sep 11

12:27pm

STI

as low as

^$314

Denver, US (DEN) - Santiago, DO (STI)

American Airlines

Sep 10

11:40am

DEN

22h 47m

LAX

MIA

Sep 11

12:27pm

STI

as low as

^$320

Denver, US (DEN) - Santiago, DO (STI)

United Airlines

Sep 10

8:13am

DEN

13h 33m

EWR

Sep 10

11:46pm

STI

as low as

^$322

Denver, US (DEN) - Santiago, DO (STI)

United Airlines

Sep 10

11:54pm

DEN

11h 3m

EWR

Sep 11

12:57pm

STI

as low as

^$322

Denver, US (DEN) - Santiago, DO (STI)

JetBlue

Sep 10

2:10pm

DEN

18h 44m

BOS

Sep 11

10:54am

STI

as low as

^$356

Denver, US (DEN) - Santiago, DO (STI)

JetBlue

Sep 10

2:10pm

DEN

19h 37m

BOS

JFK

Sep 11

11:47am

STI

as low as

^$362

Denver, US (DEN) - Santiago, DO (STI)

American Airlines

Sep 10

6:00pm

DEN

16h 27m

LAX

MIA

Sep 11

12:27pm

STI

as low as

^$410

Denver, US (DEN) - Santiago, DO (STI)

United Airlines

Sep 10

6:00am

DEN

15h 46m

ORD

EWR

Sep 10

11:46pm

STI

as low as

^$2471

Frequently Asked Questions

What are all possible destination arrival airports?

The possible destination arrival airport is Cibao International Airport. Layover airports include Minneapolis-St Paul International Airport, New York John F Kennedy Airport, General Edward Lawrence Logan International Airport, Los Angeles International Airport, Miami International Airport, Chicago O Hare Airport, and Newark Liberty Airport.

What is the time difference between destination and arrival?

Flying from Denver to Santiago entails a time difference of two hours, with Santiago being two hours ahead of Denver.

Is there a direct flight from Denver to Santiago?

There is no direct flight from Denver to Santiago. The available flights include one-stop and two-stop options, with the cheapest being a two-stop flight from Delta Air Lines at a price of $1041.

Are there convenient layover flights from Denver to Santiago?

Yes, convenient layover flights include 1-stop options from Delta Air Lines at $1100, JetBlue at $1103, American Airlines at $1320, and United Airlines at $1328. For 2-stop options, Delta Air Lines offers flights at $1041, JetBlue at $1111, American Airlines at $1328, and United Airlines at $4461.

What are the most convenient layover airports for my flight?

The most convenient layover airports for your flight from Denver to Santiago are New York John F Kennedy Airport, Minneapolis-St Paul International Airport, General Edward Lawrence Logan International Airport, Los Angeles International Airport, and Miami International Airport.

What are the cheapest and fastest flights from Denver to Santiago?

The cheapest flight is with Delta Air Lines at $1041, 30 hours 31 minutes. The fastest flight is also with Delta Air Lines at $1100, 13 hours 27 minutes.

Flights to Santiago

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Caribbean
Dominican Republic
Santiago

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Cabin Class

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Flight Deals from Denver to Santiago from $216

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Denver to Santiago

Frequently Asked Questions

Flights to Santiago