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Business Class Flight Deals from Rome to San Francisco from $1741

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Bundle + Save

Top flight deals from leading airlines:

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... and +100s more

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Stops

  • Up to 2 stops
    $3571
  • Up to 1 stop
    $2879
  • Up to nonstop
    $4296

Airlines

  • Aer Lingus
    $2879
  • Air Canada
    $4557
  • Air France
    $4431
  • Alaska Airlines
    $7123
  • American Airlines
    $3900
  • Austrian Airlines
    $13271
  • British Airways
    $3809
  • Brussels Airlines
    $4583
  • Condor
    $3571
  • Delta Air Lines
    $5521
  • Finnair
    $3900
  • Flexflight
    $5683
  • IBERIA
    $3709
  • ITA Airways
    $4296
  • KLM
    $4446
  • Lufthansa
    $4488
  • SAS Airlines
    $4004
  • SWISS
    $4490
  • TAP Portugal
    $3246
  • Turkish Airlines
    $3494
  • United Airlines
    $4453

Cabin Class

  • Business
    $2879

Departure Airports

  • Rome Fiumicino Airport
    $2879

Arrival Airports

  • Norman Y. Mineta San Jose International Airport
    $5521
  • San Francisco International Airport
    $2879

Layover Airports

  • Amsterdam Airport Schiphol
    $4446
  • Charlotte Douglas International Airport
    $3900
  • Chicago O Hare Airport
    $3859
  • Copenhagen Kastrup Airport
    $4004
  • Denver International Airport
    $4453
  • Dublin Airport
    $2879
  • Frankfurt am Main Airport
    $3571
  • Hartsfield Jackson Atlanta International Airport
    $5521
  • Humberto Delgado Airport (Lisbon Portela Airport)
    $3246
  • Istanbul Airport
    $3494
  • London Heathrow Airport
    $3709
  • Montreal Trudeau Airport
    $4557
  • New York John F Kennedy Airport
    $3809
  • Paris Charles de Gaulle Airport
    $4431
  • Philadelphia International Airport
    $3900
  • Seattle Tacoma International Airport
    $3571
  • Zürich Airport
    $4453

Best Price. GUARANTEED.

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Aer Lingus Logo
Aer Lingus

07/10/26

FCO
17h 20m
DUB

07/10/26

SFO
Aer Lingus Logo
Aer Lingus

10/14/26

SFO
17h 15m
DUB

10/15/26

FCO
$2879
TAP Portugal Logo
TAP Portugal

12/27/26

FCO
28h 10m
LIS

12/28/26

SFO
TAP Portugal Logo
TAP Portugal

01/13/27

SFO
17h 10m
LIS

01/14/27

FCO
$3246
Turkish Airlines Logo
Turkish Airlines

12/27/26

FCO
19h
IST

12/27/26

SFO
Turkish Airlines Logo
Turkish Airlines

01/13/27

SFO
18h 5m
IST

01/14/27

FCO
$3494
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
Condor Logo
Condor

07/24/26

FCO
15h 20m
FRA

07/24/26

SFO
Condor Logo
Condor

08/12/26

SFO
40h 17m
SEA
FRA

08/14/26

FCO
$3571
Aer Lingus Logo
Aer Lingus

12/27/26

FCO
28h 20m
DUB

12/28/26

SFO
IBERIA Logo
IBERIA

01/13/27

SFO
32h 20m
DUB

01/15/27

FCO
$3667
British Airways Logo
British Airways

12/18/26

FCO
15h 25m
LHR

12/18/26

SFO
IBERIA Logo
IBERIA

12/30/26

SFO
32h 55m
LHR

01/01/27

FCO
$3709
IBERIA Logo
IBERIA

08/15/26

FCO
22h 54m
JFK

08/16/26

SFO
American Airlines Logo
American Airlines

08/30/26

SFO
17h 45m
LHR

08/31/26

FCO
$3809
British Airways Logo
British Airways

08/15/26

FCO
22h 54m
JFK

08/16/26

SFO
American Airlines Logo
American Airlines

08/30/26

SFO
17h 45m
LHR

08/31/26

FCO
$3809
IBERIA Logo
IBERIA

08/10/26

FCO
22h 54m
JFK

08/11/26

SFO
IBERIA Logo
IBERIA

08/22/26

SFO
33h 44m
ORD

08/24/26

FCO
$3859
American Airlines Logo
American Airlines

07/24/26

FCO
17h 38m
CLT

07/24/26

SFO
American Airlines Logo
American Airlines

08/12/26

SFO
20h 15m
CLT

08/13/26

FCO
$3900
British Airways Logo
British Airways

08/10/26

FCO
15h 20m
LHR

08/10/26

SFO
American Airlines Logo
American Airlines

08/22/26

SFO
16h 5m
PHL

08/23/26

FCO
$3900
Finnair Logo
Finnair

08/10/26

FCO
22h 54m
JFK

08/11/26

SFO
American Airlines Logo
American Airlines

08/22/26

SFO
15h 5m
PHL

08/23/26

FCO
$3900
SAS Airlines Logo
SAS Airlines

11/20/26

FCO
35h 40m
CPH

11/21/26

SFO
SAS Airlines Logo
SAS Airlines

11/22/26

SFO
33h 25m
CPH

11/24/26

FCO
$4004
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
ITA Airways Logo
ITA Airways

07/24/26

FCO
13h 5m
Direct

07/24/26

SFO
ITA Airways Logo
ITA Airways

08/12/26

SFO
12h
Direct

08/13/26

FCO
$4296
Air France Logo
Air France

07/24/26

FCO
15h 45m
CDG

07/24/26

SFO
Air France Logo
Air France

07/31/26

SFO
13h 55m
CDG

08/01/26

FCO
$4431
KLM Logo
KLM

07/12/26

FCO
14h 15m
AMS

07/12/26

SFO
Air France Logo
Air France

07/30/26

SFO
13h 55m
CDG

07/31/26

FCO
$4446
SWISS Logo
SWISS

08/10/26

FCO
16h
ZRH

08/10/26

SFO
United Airlines Logo
United Airlines

08/22/26

SFO
21h 5m
DEN

08/23/26

FCO
$4453
Lufthansa Logo
Lufthansa

07/24/26

FCO
14h 50m
FRA

07/24/26

SFO
Lufthansa Logo
Lufthansa

08/12/26

SFO
11h 45m
Direct

08/13/26

FCO
$4488
SWISS Logo
SWISS

08/10/26

FCO
16h
ZRH

08/10/26

SFO
SWISS Logo
SWISS

08/22/26

SFO
20h 5m
ZRH

08/23/26

FCO
$4490
Air Canada Logo
Air Canada

12/27/26

FCO
18h 7m
YUL

12/27/26

SFO
Air Canada Logo
Air Canada

01/13/27

SFO
16h 35m
YUL

01/14/27

FCO
$4557
Brussels Airlines Logo
Brussels Airlines

12/27/26

FCO
18h 7m
YUL

12/27/26

SFO
United Airlines Logo
United Airlines

01/13/27

SFO
16h 35m
YUL

01/14/27

FCO
$4583
Air Canada Logo
Air Canada

07/24/26

FCO
18h 21m
YUL

07/24/26

SFO
United Airlines Logo
United Airlines

08/12/26

SFO
11h 45m
Direct

08/13/26

FCO
$4704
Brussels Airlines Logo
Brussels Airlines

12/27/26

FCO
18h 7m
YUL

12/27/26

SFO
Air Canada Logo
Air Canada

01/13/27

SFO
16h 35m
YUL

01/14/27

FCO
$4729
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
American Airlines Logo
American Airlines

08/10/26

FCO
16h 52m
ORD

08/10/26

SFO
American Airlines Logo
American Airlines

08/22/26

SFO
16h 5m
PHL

08/23/26

FCO
$4896
SWISS Logo
SWISS

08/10/26

FCO
16h
ZRH

08/10/26

SFO
SWISS Logo
SWISS

08/22/26

SFO
14h 50m
ZRH

08/23/26

FCO
$5202
Delta Air Lines Logo
Delta Air Lines

07/12/26

FCO
33h 20m
CDG

07/13/26

SFO
Delta Air Lines Logo
Delta Air Lines

07/30/26

SJC
16h
ATL

07/31/26

FCO
$5521
Finnair Logo
Finnair

08/10/26

FCO
22h 54m
JFK

08/11/26

SFO
JetBlue Logo
JetBlue

08/22/26

SFO
18h 50m
JFK

08/23/26

FCO
$5671
ITA Airways Logo
ITA Airways

07/12/26

FCO
13h 5m
Direct

07/12/26

SFO
ITA Airways Logo
ITA Airways

07/30/26

SFO
12h
Direct

07/31/26

FCO
$5683
Alaska Airlines Logo
Alaska Airlines

05/01/26

FCO
16h 3m
SEA

05/01/26

SFO
Alaska Airlines Logo
Alaska Airlines

05/15/26

SFO
33h 36m
SEA

05/17/26

FCO
$7123
ITA Airways Logo
ITA Airways

11/06/26

FCO
18h 5m
LHR

11/06/26

SFO
SWISS Logo
SWISS

11/06/26

SFO
15h
ZRH

11/07/26

FCO
$13271

Top Deals on flights Business Class from Rome to San Francisco

Rome, IT (ROM) - San Francisco, US (SFO)

 Logo

Jun 19

FCO
34h 40m
YYC

Jun 20

SFO

as low as

$1741

Rome, IT (ROM) - San Francisco, US (SFO)

 Logo

Sep 23

FCO
18h 30m
WAW

Sep 23

SFO

as low as

$2099

Rome, IT (ROM) - San Francisco, US (SFO)

TAP Portugal Logo
TAP Portugal

Sep 2

FCO
18h 50m
LIS

Sep 2

SFO

as low as

$2148

Rome, IT (ROM) - San Francisco, US (SFO)

Turkish Airlines Logo
Turkish Airlines

May 20

FCO
23h 50m
IST

May 21

SFO

as low as

$2263

Rome, IT (ROM) - San Francisco, US (SFO)

Aer Lingus Logo
Aer Lingus

Oct 11

FCO
17h 25m
DUB

Oct 11

SFO

as low as

$2454

Rome, IT (ROM) - San Francisco, US (SFO)

 Logo

Jul 7

FCO
27h 21m
KEF
BOS

Jul 8

SFO

as low as

$3025

Rome, IT (ROM) - San Francisco, US (SFO)

ITA Airways Logo
ITA Airways

Sep 23

FCO
13h 5m
Direct

Sep 23

SFO

as low as

$3362

Rome, IT (ROM) - San Francisco, US (SFO)

American Airlines Logo
American Airlines

Jul 23

FCO
17h 32m
PHL

Jul 23

SFO

as low as

$3524

Rome, IT (ROM) - San Francisco, US (SFO)

ITA Airways Logo
ITA Airways

Aug 11

FCO
13h 5m
Direct

Aug 11

SFO

as low as

$3643

Rome, IT (ROM) - San Francisco, US (SFO)

ITA Airways Logo
ITA Airways

Jul 7

FCO
13h 5m
Direct

Jul 7

SFO

as low as

$3654

Rome, IT (ROM) - San Francisco, US (SFO)

ITA Airways Logo
ITA Airways

Jul 6

FCO
13h 5m
Direct

Jul 6

SFO

as low as

$3663

Rome, IT (ROM) - San Francisco, US (SFO)

Finnair Logo
Finnair

Sep 10

FCO
21h 4m
ORD

Sep 10

SFO

as low as

$3711

Good to Know

Essential information to help you plan your flight Business Class from Rome to San Francisco

Cheapest Flight

$1741

The lowest price we found in the last two weeks, departing Jun 19 and returning Jun 20

Airline WS1 stop ‧ 34h 40m ‧ business

Fastest Flights

$4296

The fastest flight that we found in the last two weeks, departing Jul 24 and returning Aug 13

Airline AZ13h 5m ‧ business

Cheapest Flight Round-trip

$2879

Cheapest price found in the last 14 days, departing Jul 10 and returning Oct 15

Airline EI1 stop ‧ 17h 20m ‧ business

Cheapest Flight One-way

$1741

Cheapest price found in the last 14 days, departing Jun 19

Airline WS1 stop ‧ 34h 40m ‧ business

Cheapest Layover airport

$2263

The cheapest layover airport to San Francisco is currently $2263

Airline TK1 stop ‧ 23h 50m ‧ business

Best Arrival airport

$1741

The best arrival airport to San Francisco is currently $1741

Airline WS1 stop ‧ 34h 40m ‧ business

Best Departure airport

$1741

The best departure airport to San Francisco is currently $1741

Airline WS1 stop ‧ 34h 40m ‧ business

Cheapest Airline

$1741

The cheapest airline to San Francisco is currently $1741

Airline WS1 stop ‧ 34h 40m ‧ business

Flights to San Francisco