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Flight Deals from Knoxville to Santiago from $348

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Bundle + Save

Top flight deals from leading airlines:

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Incredible Deals

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

  • Up to 1 stop
    $764
  • Up to 2 stops
    $768

Airlines

  • American Airlines
    $764

Cabin Class

  • Economy
    $764

Departure Airports

  • McGhee Tyson Airport
    $764

Arrival Airports

  • Cibao International Airport
    $764

Layover Airports

  • Charlotte Douglas International Airport
    $789
  • Chicago O Hare Airport
    $805
  • Dallas Fort Worth International Airport
    $832
  • Miami International Airport
    $764
  • Reagan Washington National Airport
    $768

Best Price. GUARANTEED.

Exclusively for Priceline Members
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BUNDLE & SAVE
Book a flight & hotel together for extra savings.
On average save $240 per traveler
American Airlines Logo
American Airlines

08/01/25

TYS
15h 14m
MIA

08/01/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$764
American Airlines Logo
American Airlines

08/01/25

TYS
28h
DCA
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$768
American Airlines Logo
American Airlines

08/01/25

TYS
27h 21m
CLT
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$789
American Airlines Logo
American Airlines

08/01/25

TYS
25h 27m
CLT
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$789
American Airlines Logo
American Airlines

08/01/25

TYS
26h 50m
ORD
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$805
American Airlines Logo
American Airlines

08/01/25

TYS
31h 25m
ORD
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$831
American Airlines Logo
American Airlines

08/01/25

TYS
15h 14m
MIA

08/01/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
27h 6m
MIA
DCA

08/09/25

TYS
$832
American Airlines Logo
American Airlines

08/01/25

TYS
28h
DCA
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
27h 6m
MIA
DCA

08/09/25

TYS
$832
American Airlines Logo
American Airlines

08/01/25

TYS
26h 57m
DFW
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
16h 46m
MIA

08/08/25

TYS
$832
American Airlines Logo
American Airlines

08/01/25

TYS
25h 27m
CLT
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
27h 6m
MIA
DCA

08/09/25

TYS
$853
American Airlines Logo
American Airlines

08/01/25

TYS
15h 14m
MIA

08/01/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
17h 19m
MIA
DFW

08/09/25

TYS
$881
American Airlines Logo
American Airlines

08/01/25

TYS
28h
DCA
MIA

08/02/25

STI
American Airlines Logo
American Airlines

08/08/25

STI
17h 19m
MIA
DFW

08/09/25

TYS
$881

Top Deals on flights from Knoxville to Santiago

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
15h 14m
MIA

Aug 1

STI

as low as

$348

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
28h
DCA
MIA

Aug 2

STI

as low as

$354

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
27h 21m
CLT
MIA

Aug 2

STI

as low as

$374

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
25h 27m
CLT
MIA

Aug 2

STI

as low as

$374

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
26h 50m
ORD
MIA

Aug 2

STI

as low as

$392

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
32h 15m
ORD
MIA

Aug 2

STI

as low as

$417

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
31h 25m
ORD
MIA

Aug 2

STI

as low as

$417

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
26h 57m
DFW
MIA

Aug 2

STI

as low as

$418

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
34h 16m
DCA
MIA

Aug 2

STI

as low as

$469

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
34h 26m
PHL
MIA

Aug 2

STI

as low as

$470

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
37h 44m
PHL
MIA

Aug 2

STI

as low as

$470

Knoxville, US (TYS) - Santiago, DO (STI)

American Airlines Logo
American Airlines

Aug 1

TYS
31h 17m
DFW
MIA

Aug 2

STI

as low as

$555

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