Santo Domingo — flights from St. Louis to Santo Domingo

Flight Deals from St. Louis to Santo Domingo from $417

Name: Santo Domingo Marriott Hotel Piantini
Rating: 8.8

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Top flight deals from leading airlines:

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Good to Know

Essential information to help you plan your flight from St. Louis to Santo Domingo.

Cheapest Flight Round-trip

$699

Cheapest price found on Priceline for this route in the last 16 days. Found 3 hours ago.

$68 below the typical $767 round-trip on this route.

Outbound · Nov 13

5:02 amSTLSt Louis Lambert International Airport

2:55 pmSDQLas Américas International Airport

7h 53m · 1 stop via Miami (MIA)

Return · Nov 20

3:46 pmSDQLas Américas International Airport

9:50 pmSTLSt Louis Lambert International Airport

8h 4m · 1 stop via Miami (MIA)

Cheapest Flight One-way

$417

Lowest one-way price found on Priceline for this route in the last 16 days. Found 10 days ago.

Outbound · Nov 1

6:14 amSTLSt Louis Lambert International Airport

2:55 pmSDQLas Américas International Airport

6h 41m · 1 stop via Miami (MIA)

Good deal price

$757

A round-trip at or under $757 is a good deal on this route right now.

75% of the fares we found on this route cost more; only a quarter cost less.

Best time to fly

Afternoons

Afternoon departures average $767 on this route, the lowest of any time of day.

$16 less than the average departure, which is $783.

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American Airlinesfound Oct 19

11/13/26

5:02 am

STL

7h 53mMIA

11/13/26

2:55 pm

SDQ

11/20/26

3:46 pm

SDQ

8h 4mMIA

11/20/26

9:50 pm

STL

^$699

American Airlinesfound Oct 19

11/13/26

5:02 am

STL

7h 53mMIA

11/13/26

2:55 pm

SDQ

11/20/26

11:09 am

SDQ

8h 16mMIA

11/20/26

5:25 pm

STL

^$699

United Airlinesfound Oct 12

11/10/26

11:29 am

STL

10h 17mEWR

11/10/26

11:46 pm

SDQ

11/17/26

2:53 pm

SDQ

8h 59mEWR

11/17/26

9:52 pm

STL

^$766

American Airlinesfound Oct 19

11/13/26

5:02 am

STL

8h 56mMIA

11/13/26

3:58 pm

SDQ

11/20/26

3:46 pm

SDQ

8h 4mMIA

11/20/26

9:50 pm

STL

^$699

BUNDLE + SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

United Airlinesfound Oct 12

11/10/26

9:59 am

STL

11h 47mEWR

11/10/26

11:46 pm

SDQ

11/17/26

2:53 pm

SDQ

8h 59mEWR

11/17/26

9:52 pm

STL

^$766

American Airlinesfound Oct 19

11/13/26

10:38 am

STL

9h 5mMIA

11/13/26

9:43 pm

SDQ

11/20/26

3:46 pm

SDQ

8h 4mMIA

11/20/26

9:50 pm

STL

^$699

United Airlinesfound Oct 12

11/10/26

11:29 am

STL

10h 17mEWR

11/10/26

11:46 pm

SDQ

11/17/26

6:00 am

SDQ

12h 17mEWR

11/17/26

4:17 pm

STL

^$766

American Airlinesfound Oct 19

11/13/26

5:02 am

STL

8h 56mMIA

11/13/26

3:58 pm

SDQ

11/20/26

11:09 am

SDQ

8h 16mMIA

11/20/26

5:25 pm

STL

^$699

United Airlinesfound Oct 12

11/10/26

9:59 am

STL

11h 47mEWR

11/10/26

11:46 pm

SDQ

11/17/26

6:00 am

SDQ

12h 17mEWR

11/17/26

4:17 pm

STL

^$766

American Airlinesfound Oct 19

11/13/26

10:38 am

STL

9h 5mMIA

11/13/26

9:43 pm

SDQ

11/20/26

11:09 am

SDQ

8h 16mMIA

11/20/26

5:25 pm

STL

^$699

Top Deals on flights from St. Louis to Santo Domingo

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:14 am

STL

6h 41m1 stop · MIA

Nov 1

2:55 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:14 am

STL

7h 44m1 stop · MIA

Nov 1

3:58 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

5:02 am

STL

7h 53m1 stop · MIA

Nov 1

2:55 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

5:02 am

STL

8h 56m1 stop · MIA

Nov 1

3:58 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

10:38 am

STL

9h 5m1 stop · MIA

Nov 1

9:43 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:14 am

STL

10h 5m1 stop · MIA

Nov 1

6:19 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

5:02 am

STL

11h 17m1 stop · MIA

Nov 1

6:19 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

10:21 am

STL

9h 22m2 stops · DFW, MIA

Nov 1

9:43 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:03 am

STL

10h 16m2 stops · ORD, MIA

Nov 1

6:19 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:02 am

STL

10h 17m2 stops · PHL, MIA

Nov 1

6:19 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:00 am

STL

10h 19m2 stops · DFW, MIA

Nov 1

6:19 pm

SDQ

Search More

as low as

^$417

St. Louis, US (STL) - Santo Domingo, DO (SDQ)

American Airlines

Nov 1

6:14 am

STL

13h 29m1 stop · MIA

Nov 1

9:43 pm

SDQ

Search More

as low as

^$417

See all 12 dealsShow fewer deals

Best Santo Domingo Hotel + Flight Packages

St. Louis - Santo Domingo packages

Round-trip flight from St. Louis

STL to SDQ

Sheraton Santo Domingo

Santo Domingo, 365 George Washington Avenue

8.3376 Reviews4-Star Hotel

3% Package Savings

^$1,139/person

$2,346 $2,278 total

Incl. Flight + Hotel

Aloft by Marriott Santo Domingo Piantini

Round-trip flight from St. Louis

STL to SDQ

Aloft by Marriott Santo Domingo Piantini

Santo Domingo, , Av Abraham Lincoln Esquina Andrés Julio Aybar, Piantini

9.199 Reviews4-Star Hotel

3% Package Savings

^$1,052/person

$2,178 $2,104 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to SDQ

Catalonia Santo Domingo

Santo Domingo, Avenida George Washington, 500

8.41,348 Reviews5-Star Hotel

6% Package Savings

^$1,064/person

$2,271 $2,127 total

Incl. Flight + Hotel

Renaissance Santo Domingo Jaragua Hotel & Casino

Round-trip flight from St. Louis

STL to SDQ

Renaissance Santo Domingo Jaragua Hotel & Casino

Santo Domingo, George Washington Ave. 367, Apto. Postal 769-2

8.8316 Reviews4.5-Star Hotel

8% Package Savings

^$1,141/person

$2,481 $2,281 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to SDQ

InterContinental Real Santo Domingo

Santo Domingo, Avenida Winston Churchill Y

8.9328 Reviews5-Star Hotel

14% Package Savings

^$1,277/person

$2,953 $2,553 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to SDQ

Homewood Suites By Hilton Santo Domingo

Santo Domingo, Avenida Winston Churchill 107

9.2172 Reviews3.5-Star Hotel

11% Package Savings

^$1,203/person

$2,689 $2,405 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to SDQ

Radisson Hotel Santo Domingo

Santo Domingo, Presidente Gonzalez 10, Naco , At Tiradentes Avenue

7.8672 Reviews4.5-Star Hotel

3% Package Savings

^$982/person

$2,021 $1,963 total

Incl. Flight + Hotel

Round-trip flight from St. Louis

STL to SDQ

Santo Domingo Marriott Hotel Piantini

Santo Domingo, Distrito Nacional, Av Abraham Lincoln Esquina Andres Julio Aybar, Piantini

8.849 Reviews4.5-Star Hotel

10% Package Savings

^$1,166/person

$2,601 $2,331 total

Incl. Flight + Hotel

Best Santo Domingo Hotel + Flight + Car Packages

St. Louis - Santo Domingo packages

Round-trip flight from St. Louis

STL to SDQ

Renaissance Santo Domingo Jaragua Hotel & Casino

Santo Domingo, George Washington Ave. 367, Apto. Postal 769-2

8.8316 Reviews4.5-Star Hotel

Rental car included

Pick-up in SDQ

8% Package Savings

^$1,192/person

$2,582 $2,384 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

InterContinental Real Santo Domingo

Santo Domingo, Avenida Winston Churchill Y

8.9328 Reviews5-Star Hotel

Rental car included

Pick-up in SDQ

13% Package Savings

^$1,332/person

$3,053 $2,663 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

Homewood Suites By Hilton Santo Domingo

Santo Domingo, Avenida Winston Churchill 107

9.2172 Reviews3.5-Star Hotel

Rental car included

Pick-up in SDQ

10% Package Savings

^$1,254/person

$2,790 $2,508 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

Radisson Hotel Santo Domingo

Santo Domingo, Presidente Gonzalez 10, Naco , At Tiradentes Avenue

7.8672 Reviews4.5-Star Hotel

Rental car included

Pick-up in SDQ

3% Package Savings

^$1,034/person

$2,121 $2,067 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

Santo Domingo Marriott Hotel Piantini

Santo Domingo, Distrito Nacional, Av Abraham Lincoln Esquina Andres Julio Aybar, Piantini

8.849 Reviews4.5-Star Hotel

Rental car included

Pick-up in SDQ

10% Package Savings

^$1,217/person

$2,702 $2,434 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

Sheraton Santo Domingo

Santo Domingo, 365 George Washington Avenue

8.3376 Reviews4-Star Hotel

Rental car included

Pick-up in SDQ

3% Package Savings

^$1,192/person

$2,446 $2,384 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

Aloft by Marriott Santo Domingo Piantini

Santo Domingo, , Av Abraham Lincoln Esquina Andrés Julio Aybar, Piantini

9.199 Reviews4-Star Hotel

Rental car included

Pick-up in SDQ

3% Package Savings

^$1,104/person

$2,280 $2,208 total

Incl. Flight + Hotel + Car

Round-trip flight from St. Louis

STL to SDQ

Catalonia Santo Domingo

Santo Domingo, Avenida George Washington, 500

8.41,348 Reviews5-Star Hotel

Rental car included

Pick-up in SDQ

6% Package Savings

^$1,115/person

$2,372 $2,230 total

Incl. Flight + Hotel + Car

When is the best time of day to fly?

Afternoon (2pm - 5pm) is the cheapest time of day to fly from St. Louis to Santo Domingo. At $767 it is 2% cheaper than the average time. Evening (5pm - 9pm) is the most expensive time, 2% above average.

Show the data

When is the best time of day to fly?
Time of day	Average fare
Morning	$795
Midday	$770
Afternoon	$767
Evening	$799

What do round-trip flights from St. Louis to Santo Domingo cost?

Share of fares in each price range.

Show the data

What do round-trip flights from St. Louis to Santo Domingo cost?
Price range	Share of fares
$650 to $700	6%
$700 to $750	6%
$750 to $800	55%
$800 to $850	12%
$850 to $900	1%
$900 to $950	18%
$950 and up	<1%

Flight Deals from St. Louis to Santo Domingo from $417

Good to Know

Top Deals on flights from St. Louis to Santo Domingo

Best Santo Domingo Hotel + Flight Packages

Best Santo Domingo Hotel + Flight + Car Packages

When is the best time of day to fly?

What do round-trip flights from St. Louis to Santo Domingo cost?

Flights to Santo Domingo