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Flight Deals from Santo Domingo to Knoxville from $383

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Stops

  • Up to 1 stop
    $686
  • Up to 2 stops
    $613

Airlines

  • American Airlines
    $613
  • COPA Airlines
    $1362

Cabin Class

  • Economy
    $613

Departure Airports

  • Las Américas International Airport
    $613

Arrival Airports

  • McGhee Tyson Airport
    $613

Layover Airports

  • Charlotte Douglas International Airport
    $613
  • Chicago O Hare Airport
    $613
  • Dallas Fort Worth International Airport
    $613
  • Miami International Airport
    $613
  • New York LaGuardia Airport
    $613
  • Philadelphia International Airport
    $613
  • Reagan Washington National Airport
    $613
  • Tocumen International Airport
    $1362
  • Washington Dulles Airport
    $1362

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BUNDLE & SAVE
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On average save $240 per traveler
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 14m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 56m
DCA
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 52m
MIA
DFW

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 56m
DCA
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 52m
MIA
DFW

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 17m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 14m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
13h 23m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
15h 8m
MIA
CLT

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
13h 23m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
15h 8m
MIA
CLT

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
16h 50m
LGA
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 52m
MIA
DFW

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
14h 53m
DFW
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
18h 4m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
14h 53m
DFW
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
15h 8m
MIA
CLT

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
14h 53m
DFW
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
22h 13m
MIA
PHL

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
13h 23m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 14m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
14h 53m
DFW
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
15h 8m
MIA
CLT

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 56m
DCA
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
15h 8m
MIA
CLT

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 17m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
18h 4m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
13h 23m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
20h 35m
MIA
LGA

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 17m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
22h 19m
MIA
DCA

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
13h 23m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
18h 4m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 56m
DCA
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
17h 14m
MIA
ORD

07/29/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
15h 17m
CLT
MIA

08/05/25

SDQ
$613
American Airlines Logo
American Airlines

07/28/25

SDQ
16h 59m
MIA

07/28/25

TYS
American Airlines Logo
American Airlines

08/04/25

TYS
7h 23m
MIA

08/04/25

SDQ
$686
COPA Airlines Logo
COPA Airlines

07/28/25

SDQ
25h 32m
PTY
IAD

07/29/25

TYS
COPA Airlines Logo
COPA Airlines

08/04/25

TYS
20h 58m
IAD
PTY

08/05/25

SDQ
$1362
COPA Airlines Logo
COPA Airlines

07/28/25

SDQ
22h 33m
PTY
IAD

07/29/25

TYS
COPA Airlines Logo
COPA Airlines

08/04/25

TYS
16h 48m
IAD
PTY

08/05/25

SDQ
$1362
COPA Airlines Logo
COPA Airlines

07/28/25

SDQ
22h 33m
PTY
IAD

07/29/25

TYS
COPA Airlines Logo
COPA Airlines

08/04/25

TYS
20h 58m
IAD
PTY

08/05/25

SDQ
$1362
COPA Airlines Logo
COPA Airlines

07/28/25

SDQ
25h 32m
PTY
IAD

07/29/25

TYS
COPA Airlines Logo
COPA Airlines

08/04/25

TYS
16h 48m
IAD
PTY

08/05/25

SDQ
$1362
COPA Airlines Logo
COPA Airlines

07/28/25

SDQ
22h 33m
PTY
IAD

07/29/25

TYS
COPA Airlines Logo
COPA Airlines

08/04/25

TYS
25h 3m
IAD
PTY

08/05/25

SDQ
$1371
COPA Airlines Logo
COPA Airlines

07/28/25

SDQ
25h 32m
PTY
IAD

07/29/25

TYS
COPA Airlines Logo
COPA Airlines

08/04/25

TYS
25h 3m
IAD
PTY

08/05/25

SDQ
$1371

Top Deals on flights from Santo Domingo to Knoxville

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
18h 4m
MIA
ORD

Jul 29

TYS

as low as

$383

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
17h 14m
MIA
ORD

Jul 29

TYS

as low as

$383

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
17h 52m
MIA
DFW

Jul 29

TYS

as low as

$383

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
15h 8m
MIA
CLT

Jul 29

TYS

as low as

$383

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
20h 35m
MIA
LGA

Jul 29

TYS

as low as

$383

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
22h 13m
MIA
PHL

Jul 29

TYS

as low as

$389

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
22h 19m
MIA
DCA

Jul 29

TYS

as low as

$389

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
25h 19m
MIA
PHL

Jul 29

TYS

as low as

$389

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
16h 59m
MIA

Jul 28

TYS

as low as

$392

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

American Airlines Logo
American Airlines

Jul 28

SDQ
16h 21m
MIA
DFW

Jul 29

TYS

as low as

$449

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

 Logo

Jul 28

SDQ
34h 50m
BOG
ORD

Jul 29

TYS

as low as

$557

Santo Domingo, DO (SDQ) - Knoxville, US (TYS)

COPA Airlines Logo
COPA Airlines

Jul 28

SDQ
16h 48m
PTY
IAD

Jul 29

TYS

as low as

$733

Frequently Asked Questions

What are the most convenient layover airports for my flight?
The most convenient layover airports for your flight from Santo Domingo to Knoxville are Miami International Airport, Chicago O'Hare Airport, Charlotte Douglas International Airport, Tocumen International Airport, and Washington Dulles Airport.
What is the cheapest and fastest flight from Santo Domingo to Knoxville?
The cheapest and fastest flight is with American Airlines, priced at $613. The fastest option takes 15 hours 8 minutes with layovers at Miami International and Charlotte Douglas International airports.
What are all possible destination arrival airports?
The possible destination arrival airport is McGhee Tyson Airport, with layovers at Miami International Airport, Chicago O'Hare Airport, Charlotte Douglas International Airport, Tocumen International Airport, and Washington Dulles Airport.
What is the time difference between destination and arrival?
The total flight time from Santo Domingo to Knoxville includes various layovers and averages between 15 hours 8 minutes to 22 hours 33 minutes, depending on the flight chosen. Please check specific flight itineraries for exact times.
Is there a direct flight from Santo Domingo to Knoxville?
There is no direct flight from Santo Domingo to Knoxville. The available options include flights with 1 or 2 stops, primarily with American Airlines and COPA Airlines at various prices.
Are there convenient layover flights from Santo Domingo to Knoxville?
Yes, convenient flights from Santo Domingo to Knoxville include: American Airlines 2 stops at $613, and 1 stop at $624. COPA Airlines offers a 2 stop flight at $1362.
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