background

Flight Deals from San Diego to Guayaquil from $426

Bundle + Save

Bundle + Save

Top flight deals from leading airlines:

UA LogoB6 LogoLA LogoCM LogoQR LogoSQ LogoNH Logo

... and +100s more

Incredible Deals

Save up to 50% on select flights with Priceline

Bundle & Save

Save an average of $240 per person when bundling your flight and hotel together with Priceline

Best Price Guarantee

If a VIP member finds a better price elsewhere, we'll refund up to 200% of the difference

Help 24/7

We’re always here for you - reach us 24 hours a day, 7 days a week

Stops

  • Up to 1 stop
    $660
  • Up to 2 stops
    $614

Airlines

  • American Airlines
    $1053
  • COPA Airlines
    $660
  • JetBlue
    $935
  • LATAM Airlines Group
    $1471
  • United Airlines
    $614

Cabin Class

  • Economy
    $614

Departure Airports

  • San Diego International Airport
    $614

Arrival Airports

  • José Joaquín de Olmedo International Airport
    $614

Layover Airports

  • Chicago O Hare Airport
    $1053
  • Dallas Fort Worth International Airport
    $1111
  • El Dorado International Airport
    $614
  • Fort Lauderdale Hollywood International Airport
    $935
  • George Bush Intercontinental Houston Airport
    $614
  • Los Angeles International Airport
    $682
  • Mariscal Sucre International Airport
    $1471
  • Miami International Airport
    $1053
  • New York John F Kennedy Airport
    $935
  • Phoenix Sky Harbor International Airport
    $1053
  • San Francisco International Airport
    $614
  • Tocumen International Airport
    $614

Best Price. GUARANTEED.

Exclusively for Priceline Members
Tired of searching? Book now!
We'll refund the difference if you find a lower price.

Phone Banner

Priceline Phone Deals

Book with an agent for great rates!

BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler
United Airlines Logo
United Airlines

07/08/25

SAN
18h 30m
IAH
BOG

07/09/25

GYE
United Airlines Logo
United Airlines

07/30/25

GYE
11h 58m
PTY
SFO

07/31/25

SAN
$614
United Airlines Logo
United Airlines

07/09/25

SAN
22h 15m
IAH
BOG

07/10/25

GYE
United Airlines Logo
United Airlines

07/30/25

GYE
15h 44m
PTY
SFO

07/31/25

SAN
$614
United Airlines Logo
United Airlines

07/07/25

SAN
28h 53m
IAH
PTY

07/08/25

GYE
United Airlines Logo
United Airlines

07/30/25

GYE
11h 58m
PTY
SFO

07/31/25

SAN
$616
COPA Airlines Logo
COPA Airlines

07/07/25

SAN
16h 43m
PTY

07/08/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
13h 16m
PTY

07/30/25

SAN
$660
COPA Airlines Logo
COPA Airlines

07/07/25

SAN
16h 43m
PTY

07/08/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
28h 10m
PTY
LAX

07/31/25

SAN
$682
United Airlines Logo
United Airlines

08/01/25

SAN
28h 55m
SFO
PTY

08/02/25

GYE
United Airlines Logo
United Airlines

08/09/25

GYE
15h 43m
PTY
SFO

08/10/25

SAN
$731
COPA Airlines Logo
COPA Airlines

07/09/25

SAN
14h 14m
PTY

07/10/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
13h 16m
PTY

07/30/25

SAN
$749
COPA Airlines Logo
COPA Airlines

07/09/25

SAN
16h 43m
PTY

07/10/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
28h 10m
PTY
LAX

07/31/25

SAN
$771
COPA Airlines Logo
COPA Airlines

07/08/25

SAN
20h 50m
LAX
PTY

07/09/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
13h 16m
PTY

07/30/25

SAN
$803
COPA Airlines Logo
COPA Airlines

07/08/25

SAN
17h 2m
LAX
PTY

07/09/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
21h 55m
PTY
LAX

07/31/25

SAN
$826
COPA Airlines Logo
COPA Airlines

07/09/25

SAN
26h 50m
LAX
PTY

07/10/25

GYE
COPA Airlines Logo
COPA Airlines

07/30/25

GYE
28h 10m
PTY
LAX

07/31/25

SAN
$831
JetBlue Logo
JetBlue

08/01/25

SAN
41h
JFK
FLL

08/03/25

GYE
JetBlue Logo
JetBlue

08/08/25

GYE
28h 18m
FLL
JFK

08/09/25

SAN
$935
JetBlue Logo
JetBlue

08/01/25

SAN
41h
JFK
FLL

08/03/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
22h 21m
JFK

08/08/25

SAN
$961
JetBlue Logo
JetBlue

08/01/25

SAN
32h 58m
JFK

08/03/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
22h 21m
JFK

08/08/25

SAN
$976
JetBlue Logo
JetBlue

07/30/25

SAN
41h
JFK
FLL

08/01/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
22h 21m
JFK

08/08/25

SAN
$981
JetBlue Logo
JetBlue

07/30/25

SAN
32h 58m
JFK

08/01/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
22h 21m
JFK

08/08/25

SAN
$991
JetBlue Logo
JetBlue

07/30/25

SAN
41h
JFK
FLL

08/01/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
28h 18m
FLL
JFK

08/08/25

SAN
$995
JetBlue Logo
JetBlue

07/31/25

SAN
17h 49m
JFK

08/01/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
22h 21m
JFK

08/08/25

SAN
$1021
JetBlue Logo
JetBlue

07/31/25

SAN
17h 49m
JFK

08/01/25

GYE
JetBlue Logo
JetBlue

08/07/25

GYE
28h 18m
FLL
JFK

08/08/25

SAN
$1039
American Airlines Logo
American Airlines

07/30/25

SAN
15h 55m
PHX
MIA

07/30/25

GYE
American Airlines Logo
American Airlines

08/07/25

GYE
15h 13m
MIA
ORD

08/07/25

SAN
$1053
American Airlines Logo
American Airlines

07/30/25

SAN
15h 55m
PHX
MIA

07/30/25

GYE
American Airlines Logo
American Airlines

08/07/25

GYE
13h 44m
MIA

08/07/25

SAN
$1053
American Airlines Logo
American Airlines

08/01/25

SAN
35h 39m
ORD
MIA

08/02/25

GYE
American Airlines Logo
American Airlines

08/09/25

GYE
24h 45m
MIA
PHX

08/10/25

SAN
$1058
American Airlines Logo
American Airlines

08/01/25

SAN
33h 13m
ORD
MIA

08/02/25

GYE
American Airlines Logo
American Airlines

08/09/25

GYE
13h 44m
MIA

08/09/25

SAN
$1095
American Airlines Logo
American Airlines

08/01/25

SAN
23h 40m
ORD
MIA

08/02/25

GYE
American Airlines Logo
American Airlines

08/09/25

GYE
24h 12m
MIA
DFW

08/10/25

SAN
$1111
American Airlines Logo
American Airlines

07/30/25

SAN
24h 3m
MIA

07/31/25

GYE
American Airlines Logo
American Airlines

08/07/25

GYE
13h 44m
MIA

08/07/25

SAN
$1113
American Airlines Logo
American Airlines

08/01/25

SAN
24h 3m
MIA

08/02/25

GYE
American Airlines Logo
American Airlines

08/09/25

GYE
24h 45m
MIA
PHX

08/10/25

SAN
$1135
American Airlines Logo
American Airlines

07/31/25

SAN
23h 40m
ORD
MIA

08/01/25

GYE
American Airlines Logo
American Airlines

08/07/25

GYE
15h 13m
MIA
ORD

08/07/25

SAN
$1145
American Airlines Logo
American Airlines

07/31/25

SAN
23h 40m
ORD
MIA

08/01/25

GYE
American Airlines Logo
American Airlines

08/07/25

GYE
13h 44m
MIA

08/07/25

SAN
$1145
LATAM Airlines Group Logo
LATAM Airlines Group

07/31/25

SAN
25h 37m
IAH
UIO

08/01/25

GYE
LATAM Airlines Group Logo
LATAM Airlines Group

08/07/25

GYE
32h 55m
PTY
IAH

08/08/25

SAN
$1471
LATAM Airlines Group Logo
LATAM Airlines Group

07/31/25

SAN
25h 37m
IAH
UIO

08/01/25

GYE
LATAM Airlines Group Logo
LATAM Airlines Group

08/07/25

GYE
15h 12m
PTY
LAX

08/07/25

SAN
$1720

Top Deals on flights from San Diego to Guayaquil

San Diego, US (SAN) - Guayaquil, EC (GYE)

American Airlines Logo
American Airlines

Jul 9

SAN
24h 3m
MIA

Jul 10

GYE

as low as

$426

San Diego, US (SAN) - Guayaquil, EC (GYE)

JetBlue Logo
JetBlue

Jul 9

SAN
17h 49m
JFK

Jul 10

GYE

as low as

$509

San Diego, US (SAN) - Guayaquil, EC (GYE)

American Airlines Logo
American Airlines

Jul 9

SAN
23h 40m
ORD
MIA

Jul 10

GYE

as low as

$529

San Diego, US (SAN) - Guayaquil, EC (GYE)

LATAM Airlines Group Logo
LATAM Airlines Group

Jul 9

SAN
28h 55m
LAX
LIM

Jul 10

GYE

as low as

$549

San Diego, US (SAN) - Guayaquil, EC (GYE)

JetBlue Logo
JetBlue

Jul 9

SAN
37h 39m
BOS
JFK

Jul 11

GYE

as low as

$566

San Diego, US (SAN) - Guayaquil, EC (GYE)

American Airlines Logo
American Airlines

Jun 30

SAN
16h 4m
PHX
MIA

Jun 30

GYE

as low as

$658

San Diego, US (SAN) - Guayaquil, EC (GYE)

American Airlines Logo
American Airlines

Jun 30

SAN
24h 16m
MIA

Jul 1

GYE

as low as

$694

San Diego, US (SAN) - Guayaquil, EC (GYE)

JetBlue Logo
JetBlue

Jun 30

SAN
17h 46m
JFK

Jul 1

GYE

as low as

$705

San Diego, US (SAN) - Guayaquil, EC (GYE)

JetBlue Logo
JetBlue

Jun 30

SAN
31h 53m
BOS
JFK

Jul 2

GYE

as low as

$797

San Diego, US (SAN) - Guayaquil, EC (GYE)

American Airlines Logo
American Airlines

Jun 22

SAN
23h 44m
ORD
MIA

Jun 23

GYE

as low as

$931

San Diego, US (SAN) - Guayaquil, EC (GYE)

JetBlue Logo
JetBlue

Jun 22

SAN
31h 53m
BOS
JFK

Jun 24

GYE

as low as

$950

San Diego, US (SAN) - Guayaquil, EC (GYE)

LATAM Airlines Group Logo
LATAM Airlines Group

Jun 30

SAN
28h 58m
LAX
LIM

Jul 1

GYE

as low as

$1045

Priceline Phone Deals

Book with an agent for great rates!
Call now!

1 (888) 775-6158