$221 Flight Deals from Pittsburgh to Panama City

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Stops

Up to 1 stop
$637
Up to 2 stops
$604

Airlines

American Airlines
$604

Cabin Class

Economy
$604

Departure Airports

Pittsburgh International Airport
$604

Arrival Airports

Tocumen International Airport
$604

Layover Airports

Charlotte Douglas International Airport
$604
Miami International Airport
$604
Philadelphia International Airport
$604
Reagan Washington National Airport
$618

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BUNDLE & SAVE

Book a flight & hotel together for extra savings.

On average save $240 per traveler

American Airlines

12/04/25

7:02pm

PIT

18h 23m

PHL

MIA

12/05/25

1:25pm

PTY

American Airlines

12/07/25

2:45pm

PTY

7h 43m

MIA

12/07/25

10:28pm

PIT

^$604

American Airlines

12/04/25

7:02pm

PIT

18h 23m

PHL

MIA

12/05/25

1:25pm

PTY

American Airlines

12/07/25

4:15pm

PTY

16h 18m

MIA

CLT

12/08/25

8:33am

PIT

^$604

American Airlines

11/09/25

6:39pm

PIT

18h 57m

DCA

MIA

11/10/25

1:36pm

PTY

American Airlines

11/15/25

2:43pm

PTY

18h 6m

MIA

CLT

11/16/25

8:49am

PIT

^$618

American Airlines

11/09/25

6:39pm

PIT

18h 57m

DCA

MIA

11/10/25

1:36pm

PTY

American Airlines

11/15/25

2:43pm

PTY

8h 55m

MIA

11/15/25

11:38pm

PIT

^$618

American Airlines

12/04/25

8:15pm

PIT

19h 10m

DCA

MIA

12/05/25

3:25pm

PTY

American Airlines

12/07/25

2:45pm

PTY

18h 58m

MIA

DCA

12/08/25

9:43am

PIT

^$628

American Airlines

12/04/25

6:22am

PIT

9h 3m

MIA

12/04/25

3:25pm

PTY

American Airlines

12/07/25

2:45pm

PTY

7h 43m

MIA

12/07/25

10:28pm

PIT

^$637

American Airlines

11/09/25

6:01am

PIT

7h 35m

MIA

11/09/25

1:36pm

PTY

American Airlines

11/15/25

2:43pm

PTY

8h 55m

MIA

11/15/25

11:38pm

PIT

^$651

Top Deals on flights from Pittsburgh to Panama City

Pittsburgh, US (PIT) - Panama City, PA (PTY)

Sep 11

6:10am

PIT

8h 4m

IAH

Sep 11

2:14pm

PTY

as low as

^$221

Pittsburgh, US (PIT) - Panama City, PA (PTY)

Sep 11

6:00am

PIT

12h 37m

EWR

IAH

Sep 11

6:37pm

PTY

as low as

^$221

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Sep 11

7:06pm

PIT

19h 25m

CLT

MIA

Sep 12

2:31pm

PTY

as low as

^$274

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Nov 15

6:01am

PIT

7h 35m

MIA

Nov 15

1:36pm

PTY

as low as

^$293

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Oct 26

5:37am

PIT

8h 26m

PHL

MIA

Oct 26

2:03pm

PTY

as low as

^$293

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Oct 26

6:30am

PIT

7h 33m

MIA

Oct 26

2:03pm

PTY

as low as

^$293

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Nov 15

6:51pm

PIT

18h 45m

DCA

MIA

Nov 16

1:36pm

PTY

as low as

^$299

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Nov 8

6:36pm

PIT

19h

ORD

MIA

Nov 9

1:36pm

PTY

as low as

^$299

Pittsburgh, US (PIT) - Panama City, PA (PTY)

American Airlines

Nov 8

6:01am

PIT

7h 35m

MIA

Nov 8

1:36pm

PTY

as low as

^$312

Pittsburgh, US (PIT) - Panama City, PA (PTY)

Sep 11

10:30am

PIT

10h 4m

IAD

Sep 11

8:34pm

PTY

as low as

^$976

Frequently Asked Questions

Is there a direct flight from Pittsburgh to Panama City?

There is no direct flight from Pittsburgh International Airport to Tocumen International Airport. The available options include flights with one or two stops operated by American Airlines, with prices starting at $604.

Are there convenient layover flights from Pittsburgh to Panama City?

Yes, convenient layover flights are available. American Airlines offers a 2 stops flight for $604 with layovers in Philadelphia and Miami, taking 18 hours 23 minutes. Additionally, a 1 stop flight is offered for $637 with a layover in Miami, taking 9 hours 3 minutes.

What are the best layover airports for my flight?

The most convenient layover airports for your flight from Pittsburgh to Panama City are Miami International Airport and Philadelphia International Airport, particularly with American Airlines.

What are the cheapest and fastest flights from Pittsburgh to Panama City?

The cheapest flight is $604 with American Airlines, 2 stops, 18h 23m. The fastest flight is $651 with American Airlines, 1 stop, 7h 35m.

What are all possible destination arrival airports?

The possible destination arrival airport is Tocumen International Airport in Panama City. Layover airports include Philadelphia International Airport and Miami International Airport.

What is the time difference between destination and arrival?

The time difference between Pittsburgh and Panama City is typically one hour, with Panama City being one hour ahead.

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Flight Deals from Pittsburgh to Panama City from $221

Stops

Airlines

Cabin Class

Departure Airports

Arrival Airports

Layover Airports

Best Price. GUARANTEED.

Top Deals on flights from Pittsburgh to Panama City

Frequently Asked Questions

Flights to Panama City