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Flight Deals from Mayagueez to Detroit from $355

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Bundle + Save

Top flight deals from leading airlines:

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... and +100s more

Incredible Deals

Save up to 50% on select flights with Priceline

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Save an average of $240 per person when bundling your flight and hotel together with Priceline

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Stops

  • Up to 2 stops
    $748

Airlines

  • JetBlue
    $748
  • United Airlines
    $1243

Cabin Class

  • Economy
    $748

Departure Airports

  • Eugenio Maria De Hostos Airport
    $748

Arrival Airports

  • Detroit Metropolitan Airport
    $748

Layover Airports

  • Chicago O Hare Airport
    $1243
  • General Edward Lawrence Logan International Airport
    $748
  • George Bush Intercontinental Houston Airport
    $1303
  • Luis Munoz Marin International Airport
    $748
  • New York John F Kennedy Airport
    $748
  • Newark Liberty Airport
    $1243
  • Washington Dulles Airport
    $1243

Best Price. GUARANTEED.

Exclusively for Priceline Members
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We'll refund the difference if you find a lower price.

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BUNDLE & SAVE
Book a flight & hotel together for extra savings.
On average save $240 per traveler
JetBlue Logo
JetBlue

07/24/25

MAZ
33h 59m
SJU
JFK

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
26h 2m
BOS
SJU

08/01/25

MAZ
$748
JetBlue Logo
JetBlue

07/24/25

MAZ
30h 59m
SJU
JFK

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
26h 2m
BOS
SJU

08/01/25

MAZ
$748
JetBlue Logo
JetBlue

07/24/25

MAZ
33h 59m
SJU
JFK

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
21h 49m
BOS
SJU

08/01/25

MAZ
$768
JetBlue Logo
JetBlue

07/24/25

MAZ
30h 59m
SJU
JFK

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
21h 49m
BOS
SJU

08/01/25

MAZ
$768
JetBlue Logo
JetBlue

07/24/25

MAZ
29h 57m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
26h 2m
BOS
SJU

08/01/25

MAZ
$779
JetBlue Logo
JetBlue

07/24/25

MAZ
17h 37m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
26h 2m
BOS
SJU

08/01/25

MAZ
$785
JetBlue Logo
JetBlue

07/24/25

MAZ
20h 37m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
26h 2m
BOS
SJU

08/01/25

MAZ
$785
JetBlue Logo
JetBlue

07/24/25

MAZ
20h 37m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
12h 42m
JFK
SJU

07/31/25

MAZ
$1045
JetBlue Logo
JetBlue

07/24/25

MAZ
17h 37m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
12h 42m
JFK
SJU

07/31/25

MAZ
$1045
JetBlue Logo
JetBlue

07/24/25

MAZ
20h 37m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
10h 27m
JFK
SJU

07/31/25

MAZ
$1055
JetBlue Logo
JetBlue

07/24/25

MAZ
25h 1m
SJU
BOS

07/25/25

DTW
JetBlue Logo
JetBlue

07/31/25

DTW
10h 27m
JFK
SJU

07/31/25

MAZ
$1055
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
30h 42m
EWR
SJU

08/01/25

MAZ
$1243
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
30h 42m
EWR
SJU

08/01/25

MAZ
$1243
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
29h 55m
ORD
SJU

08/01/25

MAZ
$1250
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
29h 55m
ORD
SJU

08/01/25

MAZ
$1250
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
32h 7m
IAH
SJU

08/01/25

MAZ
$1303
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
32h 7m
IAH
SJU

08/01/25

MAZ
$1303
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
26h 17m
ORD
SJU

08/01/25

MAZ
$1310
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
26h 17m
ORD
SJU

08/01/25

MAZ
$1310
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
29h 13m
IAH
SJU

08/01/25

MAZ
$1320
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
29h 13m
IAH
SJU

08/01/25

MAZ
$1320
United Airlines Logo
United Airlines

07/24/25

MAZ
19h 51m
SJU
ORD

07/25/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
30h 42m
EWR
SJU

08/01/25

MAZ
$1348
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
20h 39m
IAD
SJU

08/01/25

MAZ
$1426
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
20h 39m
IAD
SJU

08/01/25

MAZ
$1426
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
10h 27m
IAD
SJU

07/31/25

MAZ
$1445
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 59m
SJU
IAD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
9h 27m
EWR
SJU

07/31/25

MAZ
$1445
United Airlines Logo
United Airlines

07/24/25

MAZ
9h 57m
SJU
ORD

07/24/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
9h 27m
EWR
SJU

07/31/25

MAZ
$1445
United Airlines Logo
United Airlines

07/24/25

MAZ
19h 51m
SJU
ORD

07/25/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
9h 27m
EWR
SJU

07/31/25

MAZ
$1550
United Airlines Logo
United Airlines

07/24/25

MAZ
25h 31m
SJU
ORD

07/25/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
9h 27m
EWR
SJU

07/31/25

MAZ
$1593
United Airlines Logo
United Airlines

07/24/25

MAZ
23h 17m
SJU
ORD

07/25/25

DTW
United Airlines Logo
United Airlines

07/31/25

DTW
9h 27m
EWR
SJU

07/31/25

MAZ
$1593

Top Deals on flights from Mayagueez to Detroit

Mayagueez, PR (MAZ) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 24

MAZ
33h 59m
SJU
JFK

Jul 25

DTW

as low as

$355

Mayagueez, PR (MAZ) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 24

MAZ
30h 59m
SJU
JFK

Jul 25

DTW

as low as

$355

Mayagueez, PR (MAZ) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 24

MAZ
38h 23m
SJU
JFK

Jul 25

DTW

as low as

$355

Mayagueez, PR (MAZ) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 24

MAZ
32h 57m
SJU
BOS

Jul 25

DTW

as low as

$402

Mayagueez, PR (MAZ) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 24

MAZ
20h 37m
SJU
BOS

Jul 25

DTW

as low as

$418

Mayagueez, PR (MAZ) - Detroit, US (DTT)

JetBlue Logo
JetBlue

Jul 24

MAZ
17h 37m
SJU
BOS

Jul 25

DTW

as low as

$418

Mayagueez, PR (MAZ) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 24

MAZ
9h 59m
SJU
IAD

Jul 24

DTW

as low as

$537

Mayagueez, PR (MAZ) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 24

MAZ
9h 57m
SJU
ORD

Jul 24

DTW

as low as

$546

Mayagueez, PR (MAZ) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 24

MAZ
19h 51m
SJU
ORD

Jul 25

DTW

as low as

$655

Mayagueez, PR (MAZ) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 24

MAZ
32h 5m
SJU
ORD

Jul 25

DTW

as low as

$661

Mayagueez, PR (MAZ) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 24

MAZ
18h 48m
SJU
EWR

Jul 25

DTW

as low as

$687

Mayagueez, PR (MAZ) - Detroit, US (DTT)

United Airlines Logo
United Airlines

Jul 24

MAZ
20h 13m
SJU
IAD

Jul 25

DTW

as low as

$687

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