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Flight Deals from Detroit to San Francisco from $164

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Bundle + Save

Top flight deals from leading airlines:

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... and +100s more

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Stops

  • Up to 1 stop
    $328
  • Up to nonstop
    $348

Airlines

  • Alaska Airlines
    $328
  • Delta Air Lines
    $348
  • Frontier Airlines
    $371
  • Sun Country Airlines
    $706
  • United Airlines
    $393

Cabin Class

  • Economy
    $328

Departure Airports

  • Detroit Metropolitan Airport
    $328

Arrival Airports

  • San Francisco International Airport
    $328

Layover Airports

  • Chicago O Hare Airport
    $393
  • Denver International Airport
    $371
  • Minneapolis-St Paul International/Wold-Chamberlain Airport
    $706
  • Phoenix Sky Harbor International Airport
    $371
  • Seattle Tacoma International Airport
    $328

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Alaska Airlines Logo
Alaska Airlines

10/21/26

DTW
8h 26m
SEA

10/21/26

SFO
Alaska Airlines Logo
Alaska Airlines

10/28/26

SFO
7h 32m
SEA

10/29/26

DTW
$328
Delta Air Lines Logo
Delta Air Lines

01/04/27

DTW
5h 19m
Direct

01/04/27

SFO
Delta Air Lines Logo
Delta Air Lines

01/11/27

SFO
4h 35m
Direct

01/12/27

DTW
$348
Frontier Airlines Logo
Frontier Airlines

07/11/26

DTW
19h 18m
DEN

07/12/26

SFO
Frontier Airlines Logo
Frontier Airlines

07/13/26

SFO
9h 10m
PHX

07/14/26

DTW
$371
Bundle + Save
Book a flight & hotel together for extra savings.
On average save $240 per traveler
United Airlines Logo
United Airlines

07/11/26

DTW
7h 19m
ORD

07/11/26

SFO
United Airlines Logo
United Airlines

07/13/26

SFO
8h 14m
ORD

07/14/26

DTW
$393
Sun Country Airlines Logo
Sun Country Airlines

05/29/26

DTW
9h 3m
MSP

05/29/26

SFO
Sun Country Airlines Logo
Sun Country Airlines

06/07/26

SFO
7h 13m
MSP

06/08/26

DTW
$706

Top Deals on flights from Detroit to San Francisco

Detroit, US (DTT) - San Francisco, US (SFO)

Alaska Airlines Logo
Alaska Airlines

Oct 29

DTW
8h 26m
SEA

Oct 29

SFO

as low as

$164

Detroit, US (DTT) - San Francisco, US (SFO)

United Airlines Logo
United Airlines

Jun 11

DTW
5h 6m
Direct

Jun 11

SFO

as low as

$253

Detroit, US (DTT) - San Francisco, US (SFO)

 Logo

Aug 25

DTW
10h 34m
BOS

Aug 25

SFO

as low as

$291

Detroit, US (DTT) - San Francisco, US (SFO)

Delta Air Lines Logo
Delta Air Lines

Nov 2

DTW
5h 19m
Direct

Nov 2

SFO

as low as

$303

Detroit, US (DTT) - San Francisco, US (SFO)

Sun Country Airlines Logo
Sun Country Airlines

Jun 12

DTW
14h 38m
MSP

Jun 12

SFO

as low as

$333

Detroit, US (DTT) - San Francisco, US (SFO)

Alaska Airlines Logo
Alaska Airlines

Sep 4

DTW
7h 59m
SEA

Sep 4

SFO

as low as

$381

Good to Know

Essential information to help you plan your flight from Detroit to San Francisco

Cheapest Flight

$164

The lowest price we found in the last two weeks, departing Oct 29 and returning Oct 29

Airline AS1 stop ‧ 8h 26m ‧ economy

Fastest Flights

$253

The fastest flight that we found in the last two weeks, departing Jun 11 and returning Jun 11

Airline UA5h 6m ‧ economy

Cheapest Flight Round-trip

$328

Cheapest price found in the last 14 days, departing Oct 21 and returning Oct 29

Airline AS1 stop ‧ 8h 26m ‧ economy

Cheapest Flight One-way

$164

Cheapest price found in the last 14 days, departing Oct 29

Airline AS1 stop ‧ 8h 26m ‧ economy

Cheapest Layover airport

$291

The cheapest layover airport to San Francisco is currently $291

Airline B61 stop ‧ 10h 34m ‧ economy

Best Arrival airport

$164

The best arrival airport to San Francisco is currently $164

Airline AS1 stop ‧ 8h 26m ‧ economy

Best Departure airport

$164

The best departure airport to San Francisco is currently $164

Airline AS1 stop ‧ 8h 26m ‧ economy

Cheapest Airline

$164

The cheapest airline to San Francisco is currently $164

Airline AS1 stop ‧ 8h 26m ‧ economy

Flights to San Francisco