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Flight Deals from Boston to St. Louis from $225

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Airlines

  • Air Canada
    $838
  • American Airlines
    $461
  • Delta Air Lines
    $481
  • United Airlines
    $470

Cabin Class

  • Economy
    $461

Layover Airports

  • Chicago O Hare Airport
    $470
  • Detroit Metropolitan Airport
    $481
  • Philadelphia International Airport
    $461
  • Toronto Island Airport
    $838
  • Toronto Pearson Airport
    $838

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American Airlines Logo
American Airlines

06/27/26

BOS
7h 6m
PHL

06/27/26

STL
American Airlines Logo
American Airlines

06/30/26

STL
2h 45m
Direct

06/30/26

BOS
$461
United Airlines Logo
United Airlines

06/27/26

BOS
5h 26m
ORD

06/27/26

STL
United Airlines Logo
United Airlines

06/30/26

STL
4h 48m
ORD

06/30/26

BOS
$470
Delta Air Lines Logo
Delta Air Lines

06/27/26

BOS
5h 2m
DTW

06/27/26

STL
Delta Air Lines Logo
Delta Air Lines

06/30/26

STL
12h 34m
DTW

06/30/26

BOS
$481
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Book a flight & hotel together for extra savings.
On average save $240 per traveler
Air Canada Logo
Air Canada

06/27/26

BOS
8h 11m
YYZ

06/27/26

STL
Air Canada Logo
Air Canada

06/30/26

STL
17h 37m
YTZ

07/01/26

BOS
$838
United Airlines Logo
United Airlines

07/12/26

BOS
5h 52m
ORD

07/12/26

STL
United Airlines Logo
United Airlines

07/19/26

STL
5h 9m
ORD

07/20/26

BOS
$1178

Top Deals on flights from Boston to St. Louis

Boston, US (BOS) - St. Louis, US (STL)

Delta Air Lines Logo
Delta Air Lines

Jun 30

BOS
5h 2m
DTW

Jun 30

STL

as low as

$225

Boston, US (BOS) - St. Louis, US (STL)

Delta Air Lines Logo
Delta Air Lines

Jun 30

BOS
5h 48m
ATL
STL

Jun 30

STL

as low as

$225

Boston, US (BOS) - St. Louis, US (STL)

American Airlines Logo
American Airlines

Jul 19

BOS
3h 10m
Direct

Jul 19

STL

as low as

$231

Boston, US (BOS) - St. Louis, US (STL)

American Airlines Logo
American Airlines

Jun 27

BOS
6h 6m
PHL
STL

Jun 27

STL

as low as

$245

Boston, US (BOS) - St. Louis, US (STL)

American Airlines Logo
American Airlines

Jul 14

BOS
4h 1m
DCA
STL

Jul 14

STL

as low as

$253

Boston, US (BOS) - St. Louis, US (STL)

United Airlines Logo
United Airlines

Jul 14

BOS
6h 13m
ORD
STL

Jul 14

STL

as low as

$263

Boston, US (BOS) - St. Louis, US (STL)

United Airlines Logo
United Airlines

Jun 30

BOS
5h
IAD

Jun 30

STL

as low as

$270

Boston, US (BOS) - St. Louis, US (STL)

United Airlines Logo
United Airlines

Jun 17

BOS
4h 35m
EWR
STL

Jun 17

STL

as low as

$290

Boston, US (BOS) - St. Louis, US (STL)

Delta Air Lines Logo
Delta Air Lines

Jul 15

BOS
5h 35m
LGA
STL

Jul 15

STL

as low as

$335

Boston, US (BOS) - St. Louis, US (STL)

 Logo

Jun 27

BOS
1h 55m
STL

Jun 27

STL

as low as

$409

Boston, US (BOS) - St. Louis, US (STL)

 Logo

Jun 27

BOS
3h 45m
BNA
STL

Jun 27

STL

as low as

$419

Boston, US (BOS) - St. Louis, US (STL)

American Airlines Logo
American Airlines

Jun 22

BOS
4h 47m
CLT
STL

Jun 22

STL

as low as

$455

Good to Know

Essential information to help you plan your flight from Boston to St. Louis

Cheapest Flight

$225

The lowest price we found in the last two weeks, departing Jun 30 and returning Jun 30

Airline DL1 stop ‧ 5h 2m ‧ economy

Fastest Flights

$409

The fastest flight that we found in the last two weeks, departing Jun 27 and returning Jun 27

Airline WN1 stop ‧ 1h 55m ‧ economy

Cheapest Flight Round-trip

$461

Cheapest price found in the last 14 days, departing Jun 27 and returning Jun 30

Airline AA1 stop ‧ 7h 6m ‧ economy

Cheapest Flight One-way

$225

Cheapest price found in the last 14 days, departing Jun 30

Airline DL1 stop ‧ 5h 2m ‧ economy

Cheapest Layover airport

$225

The cheapest layover airport to St. Louis is currently $225

Airline DL2 stops ‧ 5h 48m ‧ economy

Flights to St. Louis